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PHG 203 > RMP > Flashcards

RMP Flashcards

1
Q

Define rmp

A

the pd between the inside and outside of a cell that isn’t stimulated into action

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2
Q 
Rmp for 
Smooth muscle
Skeletal muscle
Cardiac muscle
Nerve cell
A
  • 50mV(unstable)(-30to-55)
  • 90mV
  • 90mV
  • 70mV
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3
Q

ICF

Proton or no proton
Electron or no electron
Alkaline or acidic

A

Proton free
Electron free
Alkaline

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4
Q

Ionic ways to fat RMP

A 
K efflux(major contributor)
Na/k Atpase( less contributor)
Cl influx (least contributor)
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5
Q

Why is Cl influx not contributing much to the Rmp generation

A

Cl influx contributes very little because of the repulsion effect

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6
Q

Why isn’t Na influx making much of a difference

A

because it’s not as fast. K is 100 times more permeable

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7
Q

Equilibrium potential of ions

A

When the rate of leaving is equal to coming in

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8
Q

Rmp of a large neurone = E_
Rmp of a small neurone= E_
Rmp of cardiac muscle = E_

A

Ek
Ecl
Ek

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9
Q

Equation to measure rmp is?

A

Nernst Goldman’s equation

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10
Q

A strength -duration curve plots - against -

A

Intensity on Y

Time on X

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11
Q 
AP or no-AP 
Subthreshold for extended time 
Subthreshold for the right time 
Subthreshold for a short time
Threshold for a short time
Threshold for extended time
Threshold for right time
Suprthreshold for short time
Supra threshold for right time
A 
No
No
No
No 
Yes
Yes
No
Yes
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12
Q

Stimulus intensity is also called-

Stimulus duration is also called-

A

Rheobase

Utilization time

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13
Q

Index of excitability is -

A

Chronaxie

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14
Q

Chronaxie is measured in ?

A

Time (s)

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15
Q

High chronaxie values means?

A

The stuff isn’t very excitable

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16
Q

Which stimulus produces local response/electrotonic potentials

A

Subthreshold stimulus

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17
Q

Nerve cell can be fatigued

T/F

A

F. It can’t be fatigued

A transmission process can be fatigued tho

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18
Q

How to fix a fatigued transmission?

A

Make the cell rehogenic

19
Q

Temporal and spatial summation

Define

A

Temporal:succession(common in pns)
Spatial:simultaneous (common in cns)

20
Q

Range of absolute refractory period

A

From start of depolarization to 1/3 of repolarization

21
Q

Duration of absolute refractory period in mammalian nerve

A

0.4-1msec

22
Q

Reason for Absolute refractory period

A

this is due to the sodium gates already being engaged and therefore unresponsive

23
Q

Range of relative refractory period

A

From 1/3 of repolarization to start of after-depolarization

24
Q

What type of stimulus can fire an AP during relative refractory period

A

Suprathreshold stimulus

25
Q

Why must the stimulus in RRP be Suprathreshold

A

because there are numerous activated K channels causing hyperpolarization

26
Q

Stimulus artifacts is produced by the nerve

A

F. It’s a product of human intervention

27
Q

Define latency period

A

Isopotential interval from artifact point to start of AP

28
Q

Effect of changing distance between recording and stimulating electrode on latency period

A

Increase distance, increase latency period which would reduce speed of conduction

29
Q

RMP can be measure with -

AP can be measured with - or -

A

Erm

IRM or erm

30
Q

Skeletal ,cardiac,nerve , smooth muscle

Arrange in order of decreasing spike duration

A

Cardiac 300msec
Smooth 50msec
Skeletal 2-5msec
Nerve. 1msec

31
Q

Which is more prominent?

After depolarization or after hyperpolarization

A

After hyperpolarization

32
Q

Duration of the after potentials in a neurone

A

After depo- 4ms

After hyper-40ms

33
Q

Spike potential and after potential are independent of each other
T/F

A

T. Change in one doesn’t affect the other

34
Q

In generating AP in a neuron, is the peak reached?

A

No. The peak is Ena (60mV) but it usually stops at 40mV due to sodium gates closing and repulsion (++)

35
Q

Duration of SA node AP

A

250msec

36
Q

Difference between SA node AP and cardiac AP

A

Initial depo is by rapid Ca not rapid Na

Pre potential is by slow Na gates

37
Q

How to maintain cardiac AP

A

By activity of Na/K atpase
Z^3
If sodium doubles, Na/k activity increases by 8folds

38
Q

Mentions 3 waves that are imposed on rmp in smooth muscles

A

Spike, slow waves and pacemaker potentials

39
Q

Slow waves is independent of nerve supply

T/F

A

T. It’s by ENS

40
Q

Spikes can only occur during depo phase of slow waves

A

F. Can occur at any phase

41
Q

Spikes have variable peak potentials

T/F

A

T

42
Q

Excitation-contraction effect in smooth muscle

A

Slow
Contraction starts 200ms after excitation (spike)
Ends 150ms after spike is over
Peak contraction is 500msec after spike starts

43
Q

excitation-contraction effect in cardiac and skeletal muscles

A

Less than 10msec

44
Q

SALTATORY and ELECTROTONIC Conduction of AP

Myelination
Movement

A

S: myelinated and jumps from node to nodes;dense Na channels at nodes and least at soma ; Na is flanked by K

E: unmyelinated;must occur at every point of the nerve

PHG 203 (22 decks)

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