ADRENERGIC & CHOLINERGIC

Question 1

Tyrosine (Tyr) is transported into the noradrenergic nerve terminal by a——— carrier

Answer 1

Na+-dependent

Question 2

Rate limiting step in catecholamines synthesis is???

Answer 2

conversion of Tyr to dopa

Question 3

conversion of Tyr to dopa then to dopamine occurs in the——-

Answer 3

cytoplasm of the axon

Question 4

VMAT can be blocked by the drug ——

Answer 4

reserpine

Question 5

Dopamine is converted to NE in——-

Answer 5

the vesicle

Question 6

NE is expulsed from vesicle with—- and—-

Answer 6

ATP

peptides

Question 7

NE’s expulsion involves ———and ——that can be blocked by drugs such as——- and——

Answer 7

synaptosome-associated proteins (SNAPs)

vesicle-associated membrane proteins (VAMPs)

guanethidine

bretylium

Question 8

NET can be blocked by—— and—-

Answer 8

cocaine

tricyclic antidepressants.

Question 9

Norepinephrine released from the synaptic vesicles diffuses across the synaptic space and binds to either postsynaptic receptors on the effector organ or to presynaptic receptors on the nerve ending.
T/F

Answer 9

T

Question 10

COMT is found in ——-

While MAO is found in —-

Answer 10

Post synaptic membrane

Presynaptic membrane