Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

1. Infection & Immunity > Rickettsia, Coxiella, Ehrlichia, Anaplasma > Flashcards

Rickettsia, Coxiella, Ehrlichia, Anaplasma Flashcards

1
Q

Rickettsia general characteristics

A

Gram - bacteria
Obligate intracellular of vasc. endothelium
Stain with Giema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

R. rickettsii is the causative agent of …

A

Rocky Mountain Spotted Fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Rickettsia distribution

A

Throughout US (south central states), southern Canada, Central America, South America (New world)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

R. rickettsii

A

Humans and dogs show clinical illness (petechiae)
Cats resistant to RMSF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

R. felis

A

Not pathogenic to cats
Zoonotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Rocky Mountain Spotted Fever

A

Most severe and reported rickettsial illness of humans in the US
Reportable, 90% in april- sep

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Rocky Mountain Spotted Fever transmission

A

Ticks, fleas, mites and lice
20 Ixodid tick species → mostly Demacentor spp.
Transovarial and transstadial

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Rickettsia exposure

A

1-3% ticks carry agent
6-20 h of attachment and feeding required

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Dogs are _______ for the presence of RMSF

A

Sentinels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Rickettsia pathogenesis

A

On vascular endothelial and smooth muscle cells causing necrotizing vasculitis (escape from phagosome and cytosolic replication by binary fission) → rashes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Rickettsia diagnostics

A

Isolation (BSL 3 contaminent)
Immunofluorescent assay and ELISA
PCR assays (with tick with possible)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Rickettsia are sensitive to _________

A

tetracyclines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Coxiella burnetii is the causative agent for ________

A

Q fever
zoonotic, bioterrorism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Coxiella general characteristics

A

Small pleomorphic rods, intracellular
MZN (modified Ziehl Neelson) stain
Small cell variant (SCV) or vegetative large cell variant (LCV)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Coxiella transmission

A

Aerosol, ingestion
Limited transmission by ticks
Wind-borne over long distances

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Coxiella survival

A

Survives in environment for months
Formalin, UV, classical or flash pasteurization, desiccation
0.5% Na hypochlorite

17
Q

Coxiella pathogenesis

A

Invades vascular endothelium, respiratory and renal epithelia→ multiply in phagosomes and macros

18
Q

Q fever

A

Febrile, occupational disease
Cattle, sheep, goats= reservoirs

19
Q

Q fever latent infection

A

Placentitis with abortion or norm delivery → discharge of bacteria
In lactating mammary gland and uterus
Reactivated during parturition

20
Q

C. burnetii diagnostics

A

Serology and molecular methods
BSL-3 labs permitted to culture

21
Q

C. burnetti disinfection

A

Ethyl alcohol, chloroform, N-alkyl dimethyl benzyl and ammonium chloride inactivate within 30 mins

22
Q

Ehrlichia and Neorickettsia general characteristics

A

Obligate intracellular, gram -
Found in granulocytes or monocytes as morulae
Causes acute or chronic disease (vascular disorders)

23
Q

E. canis

A

Canine monocytic ehrlichiosis (CME)
Vector: brown dog tick (Rhipcephalus sanguineus)

24
Q

E. ewingii

A

Canine granulocytic ehrlichiosis (CGE)
Vector: Lone star tick (amblyomma americanum)

25
Q

Canine ehrlichiosis

A

Causes coagulation disorders: petechiae, epistaxis from vasculitis and thrombocytopenia, anemia (pancytopenia)

26
Q

_____________ smear from hosts examined fro morulae for Ehrlichia

A

Buffy coat

27
Q

Neorickettsia risticci

A

Cause of Potomac Horse fever (equine monocytic ehrlichiosis- EME)-
June to Sep

28
Q

N. risticii pathogenesis

A

Infects equine monocytes, intestinal epithelium and colonic mast cells

29
Q

N. risticii transmission

A

Flukes in water
Snails and flies intermediate hosts with flie

30
Q

CS for N. risticii

A

Fever, anorexia, colic, depression, ileus, diarrhea and laminitis

31
Q

Causes of eneterocolitis

A

Salmonellosis, clostridial colitis, antibiotic-induced colitis, parasites (strongyles)

32
Q

Salmon poisoning in dogs

A

Caused by N. helminthoeca
Reservoir: eating raw fish with fluke*
In Northwestern USA

33
Q

Salmon poisoning pathogenesis

A

Dog releases fluke eggs (fecal) → miracidia infects snail → cercaria infests salmon → dogs eats salmon

34
Q

Salmon poisoning CS

A

Infects monocytes → fever, anorexia, depression, WL, swollen LNs, hemorragic enteritis

35
Q

Anaplasma

A

Obligate intracellular
A. phagocytophilum* (neutros)
A. marginale and centrale of cattle

36
Q

Anaplasma pathogenesis

A

Tickborne that parasitizes erythrocytes, phagocytes and platelets
Membrane-bound morulae in cells

37
Q

A. phagocytophilum distribution

A

Upper midwest and coastal new england (ixodes scapularis)

38
Q

SNAP 4Dx Plus test by IDEXX

A

Detects Abs produced by A. phagocytophilum, A. platys, B. burgdorferi, E. canis, E. ewingii
Detects heartworm Ag

39
Q

Treatment for anaplasmosis

A

Doxycycline

1. Infection & Immunity (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions