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1. Infection & Immunity > Mycoplasma + Chlamydia > Flashcards

Mycoplasma + Chlamydia Flashcards

1
Q

Mycoplasma belongs to the class_________

A

Mollicutes

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2
Q

Mycoplasma morphology

A

Smallest prokarys
Lack cell wall
Facultative anaerobes

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3
Q

Mycoplasma nutritional requirements

A

Limited biosynthetic potential (depend on host micoenvironment)
Exogenous fatty acids and sterols required

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4
Q

Mycoplasma growth

A

Require special media
Generation time of 1-6 hours
Fried egg appearance

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5
Q

Non-hemotropic mycoplasma

A

Most affect mucous membranes
Direct or indirect contact
Ex: Myco bronchopneumonia (M. bovis)

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6
Q

CS of non-hemotropic myoplasma

A

Respiratory and urogenital infections
Conjunctivitis, arthritis, mastitis, septicemia, otitis media

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7
Q

Hemotropic mycoplasma/ Hemoplasma

A

Transmitted by arthropods
Colonize RBCs (hemolysis)
Small, rod, on RBC surface

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8
Q

Hemotropic Mycoplasma CS

A

Hemolytic anemia, icterus, splenomegaly
Dx: Wrights, Giemsa, Diff-Qik

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9
Q

M. gallisepticum

A

Chronic resp. disease (CRD)
Most pathogenic avian myco.
Turkeys more susceptible
Swollen infraorbital sinuses

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10
Q

Chronic respiratory disease CS

A

Sinusitis, nasal discharge, coughing, sneezing, respiratory rales, conjunctivitis

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11
Q

M. synoviae

A

Upper resp. infection, airsacculitis, synovitis, green diarrhea and liver,
Subclinical/ carrier infections

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12
Q

M. meleagridis

A

Resp. disease in turkeys (via eggs)
Stunted growth, poor feathering and leg problem

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13
Q

M. iowae

A

Reduced hatchability, embryo mortality, resp. and leg problems in turkeys

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14
Q

How do you treat Mycoplasma in birds?

A

Macrolides: Erythromycin, azithromycin, tetracycline
Tylosin for meleagridis

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15
Q

Mycoplasma species in swine

A

M. hyopneumoniae, hyosynoviae, hyorhinis

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16
Q

M. hyopneumoniae

A

Porcine enzootic pneumonia
Economic problem worldwide
Damages airways cilia

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17
Q

M. hyosynoviae

A

Sporadic disease with polyarthritis in young animals 3-6 months

18
Q

M. hyorhinis

A

Sporadic polyserositis and polyarthritis in young animals
Indistinguishable from Glasser’s in pigs <3 months old

19
Q

M. bovis

A

Bronchopneumonia
Shipping fever and calf pneumonia
$32 million/yr for US

20
Q

CS of M. bovis

A

Arthtritis, keratovonjunctivitis, mastitis, abortions, otitis, abscess, oophoritis, genital infection

21
Q

Contagious agalactia

A

Small ruminants
Mastitis, arthritis, conjunctivitis
Causes by M. mycoides capri, capricolum capricolum

22
Q

Mycoplasma in cats and dogs

A

Oropharyngeal flora in cats
Upper resp, tracts of dogs
M. cynos: canine infectious resp. disease

23
Q

M. felis

A

Causes conjunctivitis and secondary pneumonia
Pathogen for pleuritis in horses

24
Q

What are the 4 common agents causing feline conjunctivitis

A

Feline herpes viris
Chlamydia
Mycoplasma
Calicivirus

25
Mycoplasma pathogenesis
Interfere with host cell protein and ATP synthesis Damage and loss of cilia in resp. tract Buildup in cytotoxic metabolites and enzymes
26
Mycoplasma diagnosis
PCR** Skin scrape for cats (stain for IBs) Culture (not practical)
27
_____________ infection is the most widespread bacterial STD in the world and top reported disease to CDC
C. trachomatis
28
Chlamydia general characteristics
Intracellular: grow in yolk sac and tissue culture, energy dependent (energy parasites) Cell wall visible by giemsa (DiffQuik)
29
Elementary bodies of chlamydia
Infectious forms Can survive in water for several days and dry environ for longer Released by lysis
30
Reticulate bodies of chlamydia
Larger, non-infectious intracellular forms Metabolically active, can replicate
31
Chlamydia life cycle
In vitro for 30-40 hrs
32
Chlamydia is spread through ________
direct contact
33
Chlamydia pathogenesis
Infects epithelial cells Host macromolecule synthesis ceases Cell autolysis LPS and tissue damage initiates inflammatory rx
34
Psittacosis/ orinthosis (parrot fever)
Chlamydial disease (notifiable) Category B agent Caused by C. psittaci Occupational disease
35
Psittacosis susceptibility
Pigeons develop a subclin disease Turkeys more sensitive 50-80% morbidity
36
Psittacosis CS
Fever, anorexia, conjunctivitis, yellow-green gelatinous droppings Drop in egg production Pneumonitis, arthritis
37
Psittacosis transmission
Inhalation of aerosolized bacteria from droppings, feathers or tissues, urine, saliva, feces, etc.
38
Chlamydial abortion
In women, cattle, sheep, pigs and horses Casues by C. abortus Late pregnancy abortions and retained placenta
39
C. felis
In cats causes acute, chronic or recurrent conjunctivitis < 1 yr old IBs
40
Chlamydia diagnosis
IBs show in cytology/ staining PCR Tissue culture IFAT (immunofluorescent Ab test)
41
Chlamydia sensitivity
Doxycycline (act on protein synthesis) Quaternary ammonium compounds and chlorphenol, 1% bleach disinfectants

1. Infection & Immunity (19 decks)

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