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Y2 Revision > Rheumatology - CORTEXT > Flashcards

Rheumatology - CORTEXT Flashcards

1
Q

what is the basic pathology behind connective tissue diseases?

A

autoimmunity, producing antibodies against the cells of the body

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2
Q

who is SLE more common in?

A

black people

women

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3
Q

which antibodies are associated with SLE (6)?

A 
ANA 
anti dsDNA 
anti Sm 
anti Ro 
anti La
anti RNP
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4
Q

true or false: complement levels are high in active SLE

A

false

they are low

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5
Q

why is urinalysis done in SLE?

A

to look for glomerulonephritis

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6
Q

what is the management for mild SLE?

A

hydroxychloroquine
topical steroids
NSAIDs

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7
Q

what is the management for moderate SLE?

A

immunosuppression

steroids

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8
Q

what is the management for severe SLE?

A

IV steroids

cyclophosphamide

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9
Q

what is the basic pathogenesis of Sjogren’s syndrome?

A

autoimmune destruction of exocrine glands

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10
Q

list two clinical features of Sjogren’s syndrome

A

dry mouth and eyes

parotid swelling

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11
Q

which autoantibodies are associated with Sjogren’s syndrome?

A

anti Ro

anti La

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12
Q

what is the basic pathogenesis in systemic sclerosis?

A

excess collagen deposition, causing skin and organ changes

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13
Q

what is the difference between limited and diffuse systemic sclerosis?

A

limited = mainly confined skin changes

diffuse = rapid skin changes and early organ involvement

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14
Q

which systemic sclerosis (limited or diffuse) is associated with anti-centromere antibody?

A

limited

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15
Q

which systemic sclerosis (limited or diffuse) is associated with anti Scl 70 antibody?

A

diffuse

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16
Q

what is a common skin change that occurs in systemic sclerosis?

A

raynaud’s

17
Q

CREST describes findings in systemic sclerosis, what does it stand for?

A 
calcinosis 
raynaud's 
esophageal dysmotility 
sclerodactyly 
telangiectasia
18
Q

what does antiphospholipid syndrome increase the risk of?

A

clots

19
Q

in females, what is the most important consequence of APS?

A

pregnancy loss

20
Q

which immunological factors are associated with APS?

A

lupus anticoagulant
anti cardiolipin antibody
anti beta 2 glycoprotein

21
Q

what is the treatment for APS?

A

anticoagulation for thrombosis

LMWH if pregnant

Y2 Revision (95 decks)

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