Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Y2 Revision > Connective Tissue Disease > Flashcards

Connective Tissue Disease Flashcards

1
Q

what is the general pathology behind connective tissue disease?

A

autoimmunity

antibodies produced against the cells of the body

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

true or false: SLE affects more males than females

A

false

females nine times more than males

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

in which ethnic groups is the prevalence of SLE higher?

A

afro-americans
afro-caribbeans
asians

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

list general symptoms of SLE

A

fatigue
skin changes
malaise
joint pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

list skin changes in SLE

A

malar/butterfly/discoid rash. sparing nasolabial fold

photosensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

true or false: SLE can be a totally cutaneous disease

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

list musculoskeletal changes in SLE

A

joint pain
non deforming arthritis
myopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is the difference between mild, moderate and severe SLE?

A

mild - simple cutaneous changes
moderate - arthritis, effusions etc.
severe - organ threatening disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are the main screening tests for SLE?

A

FBC
urinalysis
renal function
antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the main antibodies that are raised in SLE?

A

ANA
anti-ds-DNA
anti-Sm
ENA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

true or false: ANA is the most diagnostic antibody in SLE

A

false

anti double stranded DNA is the most specific

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

list the general treatment for SLE

A

NSAIDs
anti malarial
steroids
immunosuppressants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is the anti malarial used for SLE?

A

hydroxychloroquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

true or false: steroids can be used as monotherapy in SLE

A

false

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is antiphospholipid syndrome?

A

an autoimmune disease where antibodies are produced against phospholipids, increasing the risk of blood clots

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

list the potential lab findings of anti phospholipid syndrome

A

positive anti phospholipid antibody
lupus anticoagulation activity
anti beta 2 glycoprotein

17
Q

list the potential clinical findings in APS

A

thrombosis

pregnancy loss

18
Q

what is sjogren’s syndroem?

A

autoimmune destruction of exocrine glands

19
Q

what is systemic sclerosis?

A

autoimmune inflammation and thickening of the skin due to increased collagen deposition

20
Q

what happens in raynaud’s phenomenon?

A

reduced blood flow

21
Q

limited systemic sclerosis was known as CREST - what does this stand for?

A 
calcinosis
raynaud's 
esophageal dysmotility 
sclerodactyly
telangiectasia
22
Q

which antibodies are associated with systemic sclerosis?

A

anti-centromere (limited)

anti Scl 70 (diffuse)

23
Q

which antibody is associated with sjogren’s syndrome?

A

anti Ro

anti La

Y2 Revision (95 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions