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Misc. Notes Year 2 > Rheumatoid Drugs side effects > Flashcards

Rheumatoid Drugs side effects Flashcards

1
Q

What is the mechanism of action of Methotrexate (be specific)

A

Folate antagonist

Binds dihydrofolate reductase

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2
Q

What modes of administration are available for Methotrexate

A

Oral

Subcutaneous

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3
Q

Which side effect of Methotrexate affects the lungs

A

Pneumonitis –> pulmonary fibrosis

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4
Q

Name 2 other side effects of Methotrexate apart from Pneumonitis

A

Hepatotoxicity

Myelosuppression

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5
Q

What must you take into consideration when prescribing methotrexate

A

Teratogenic

stop males and female 3 months before conception

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6
Q

What kind of drug is Sulfasalazine

A

Aminosalicylate

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7
Q

What modes of administration are available for Sulfasalazine

A

Oral

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8
Q

Name 4 side effects of Sulfasalazine

Repro, Neuro, Derm, GI

A

Temporary oligospermia
Depression
Ulcers/ Rash
Hepatitis

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9
Q

Name 2 ocular side effects of Hydroxychloroquine

A

Irreversible Retinopathy

Corneal deposits

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10
Q

Name 1 respiratory side effect and 2 GI side effects of Leflunomide

A

Interstitial lung disease

GI upset + Hepatotoxicity

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11
Q

What is the route of administration of Gold

A

IM

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12
Q

Name a renal and an MSK side effect of IM Gold

A

Proteinuria

Peripheral Neuropathy

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13
Q

What is the name of the rash that Penicillamine can cause

A

Pseudoxanthoma elasticum

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14
Q

Which GI disease can Penicillamine be used for

A

Wilson’s disease

as a chelating agent

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15
Q

Name 3 GI side effects of Azathioprine

A

Hepatotoxicity
Acute pancreatitis
GI upset

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16
Q

Is Azathioprine safe for young people wanting to conceive

A

No, it is teratogenic

17
Q

What is the mechanism of action of Ciclosporin

A

Blocks cytotoxic T cell activation

18
Q

Which of the Anti-TNF drugs is given IV

A

Infliximab

19
Q

Name 2 contra-indications of using Anti-TNF drugs

A

Heart Failure

Pulmonary fibrosis

20
Q

Which side effect is common to all the Anti-TNF drugs

A

Re-activation of TB

21
Q

Which anti-TNF drug can cause demyelination

A

Etanercept

22
Q

Which drug can cause exacerbation of myasthenia gravis

A

Penicillamine

23
Q

Which rheumatoid drug apart from methotrexate and azathioprine is not used in pregnancy

A

Leflunomide

24
Q

A patient taking an intramuscular DMARD presents with an itchy erythematous rash covering the whole body
Which drug is responsible and what is the rash called

A

Gold

Exfoliative Dermatitis

Misc. Notes Year 2 (30 decks)

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