Rheumatoid Drugs side effects Flashcards
What is the mechanism of action of Methotrexate (be specific)
Folate antagonist
Binds dihydrofolate reductase
What modes of administration are available for Methotrexate
Oral
Subcutaneous
Which side effect of Methotrexate affects the lungs
Pneumonitis –> pulmonary fibrosis
Name 2 other side effects of Methotrexate apart from Pneumonitis
Hepatotoxicity
Myelosuppression
What must you take into consideration when prescribing methotrexate
Teratogenic
stop males and female 3 months before conception
What kind of drug is Sulfasalazine
Aminosalicylate
What modes of administration are available for Sulfasalazine
Oral
Name 4 side effects of Sulfasalazine
Repro, Neuro, Derm, GI
Temporary oligospermia
Depression
Ulcers/ Rash
Hepatitis
Name 2 ocular side effects of Hydroxychloroquine
Irreversible Retinopathy
Corneal deposits
Name 1 respiratory side effect and 2 GI side effects of Leflunomide
Interstitial lung disease
GI upset + Hepatotoxicity
What is the route of administration of Gold
IM
Name a renal and an MSK side effect of IM Gold
Proteinuria
Peripheral Neuropathy
What is the name of the rash that Penicillamine can cause
Pseudoxanthoma elasticum
Which GI disease can Penicillamine be used for
Wilson’s disease
as a chelating agent
Name 3 GI side effects of Azathioprine
Hepatotoxicity
Acute pancreatitis
GI upset
Is Azathioprine safe for young people wanting to conceive
No, it is teratogenic
What is the mechanism of action of Ciclosporin
Blocks cytotoxic T cell activation
Which of the Anti-TNF drugs is given IV
Infliximab
Name 2 contra-indications of using Anti-TNF drugs
Heart Failure
Pulmonary fibrosis
Which side effect is common to all the Anti-TNF drugs
Re-activation of TB
Which anti-TNF drug can cause demyelination
Etanercept
Which drug can cause exacerbation of myasthenia gravis
Penicillamine
Which rheumatoid drug apart from methotrexate and azathioprine is not used in pregnancy
Leflunomide
A patient taking an intramuscular DMARD presents with an itchy erythematous rash covering the whole body
Which drug is responsible and what is the rash called
Gold
Exfoliative Dermatitis
