Respiratory Pathology - 4 (other pneumonias) Flashcards

1
Q

Lung abscesses can be complications of Pneumonia often caused by which 2 bacteria?

A

Staph. Aureus

Klebsiella Pneumoniae

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2
Q

Lung abscesses can also be seen with Aspiration Pneumonia. What patients are at an elevated risk for Aspiration Pneumonia?

A

Chronic alcoholics

Elderly (stroke)

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3
Q

What type of bacteria is commonly a culprit of Aspiration Pneumonia?

A

Anaerobic bacteria

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4
Q

What lobes of the lungs are preferentially affected by Aspiration Pneumonia and why?

A

RIGHT middle and lower lobes

– aspiration of food follows most down-sloping airway segment which is the right side

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5
Q

Lung abscesses can be a complication of pneumonia, often due to which 2 bacteria?

A

S. Aureus

K. Pneumoniae

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6
Q

Tuberculosis involves ____

A

Caseation = cheese necrosis

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7
Q

What is the complex called that is seen on the lungs with Tuberculosis?

A

Ghon complex - localized caseation

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8
Q

A primary infection of Tuberculosis can become latent. What can it turn into?

A
  • Secondary Tuberculosis with reinfection or reactivation of primary infection
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9
Q

If Tuberculosis is severe enough, what will occur and what will be affected?

A

Hematogenous Dissemination

= Miliary Tuberculosis (spleen and liver)

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10
Q

Localized caseation of the lungs is seen with Tuberculosis, what is that complex called?

A

Ghon complex

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11
Q

What defines Chronic Pneumonia?

A

Pneumonia lasting for months in an immunocompetent patient

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12
Q

Chronic Pneumonia is often due to what type of organism?

A

Fungal

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13
Q

Which 3 fungal organisms are often at fault for Chronic Pneumonia?

A

Histoplasma Capsulatum
Blastomyctes Dermatitides
Coccidiodes Immitis

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14
Q

Which 3 fungal organisms are often at fault for Chronic Pneumonia?

A

Histoplasma Capsulatum
Blastomyces Dermatitides
Coccidiodes Immitis

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15
Q

Where is infection with Histoplasma Capsulatum common?

A

Midwest (ohio and MI river valleys) and caribbean

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16
Q

Symptoms of Histoplasma Capsulatum?

A

Subclinical (asymptomatic)

– if immunocompromised = more aggressive

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17
Q

What morphology of the yeast form will be seen with Histoplasma Capsulatum?

A

Pumpkin seed

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18
Q

Pumpkin seed morphology

A

Histoplasma Capsulatum

– chronic pneumonia

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19
Q

Where is infection with Blastomyces Dermatitides common?

A

Central and SE US (ohio and MI river valleys)

20
Q

What else can Blastomyces Dermatitides affect?

A

Skin and sometimes disseminated infection

21
Q

What morphology of the yeast is seen with Blastomyces Dermatitides?

A

Broad - Based Budding yeast

22
Q

Broad Based Budding Yeast

A

Blastomyces Dermatitides

– chronic pneumonia

23
Q

Where is infection with Coccidiodes Immitis common?

A

SW US and mexico

24
Q

Symptoms of Coccidiodes Immitis?

A

Subclinical (asymptomatic)

– Disseminated infection in immunocompromised

25
What cells are present with Coccidiodes Immitis?
Eosinophils
26
The 3 fungal organisms that cause chronic pneumonia will have what type of response in the lungs?
Granulomatous | = calcifications or coin lesions on CXR
27
The 3 fungal organisms that cause chronic pneumonia will have what type of response in the lungs?
Granulomatous | = calcifications or coin lesions on CXR
28
What does the morphology of Coccidiodes Immitis look like?
Circumscribed circle with eosinophils | -- chronic pneumonia
29
What are 3 common causes of Pneumonia in Immunocompromised patients?
Pneumocystis Jiroveci Cytomegalovirus Mycobacterium Avium Complex
30
What are 3 common causes of Pneumonia in Immunocompromised patients?
Pneumocystis Jiroveci Cytomegalovirus Mycobacterium Avium Complex
31
Pneumocystis Jiroveci
Opportunistic FUNGAL infection | - AIDS defining illness
32
What does the yeast look like morphologically for Pneumocystis Jiroveci?
Cup shaped
33
Cup shaped yeast
Pneumocystis Jiroveci
34
What does Pneumocystis Jiroveci look like radiographically?
ANYTHING - can be diffuse or focal
35
Cytomegalovirus
Opportunistic VIRAL infection | - AIDs defining illness
36
What do the cells look like with Cytomegalovirus?
BIG cell virus with Cowdry inclusions | = pink/purple in nucleus
37
BIG cells with cowdry inclusions in the nucleus
Cytomegalovirus
38
How does Cytomegalovirus look on CXR?
Diffuse infiltrates
39
How does Mycobacterium Avium Complex look morphologically on acid fast stain?
Slender red forms
40
Slender red forms on acid fast stain
Mycobacterium Avium Complex
41
With a lung transplant, what is needed to differentiate from rejection or infection?
Biopsy
42
Fever and infiltrates after a lung transplant could be?
Infection | Rejection
43
What does lung transplant rejection show on biopsy?
Mononuclear infiltrates around vessels
44
Mononuclear infiltrates around vessels suggests?
Rejection of lung transplantation
45
What 2 organisms are commonly to blame for infections after a lung transplantation?
Zygomycosis | Cytomegalovirus