Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

2 - CPR (pulmonary) > Asthma and COPD Drugs (cont.) > Flashcards

Asthma and COPD Drugs (cont.) Flashcards

1
Q

MOA for Beta 2 Agonists?

A

Active Beta 2 receptors to relax smooth muscle and cause bronchildation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are some possible adverse effects with the use of Albuterol?

A

Insomnia, dry mouth, cough

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which SABA is the only one available by Subcutaneous Injection?

A

Terbutaline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is Terbutaline given?

A

SubQ injection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Patient with what allergy should not use Terbutaline (SABA)?

A

Sulfur allergy patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the main adverse effects seen with the use of Terbutaline?

A

Tachycardia and palpitations

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the main system effects of Pirbuterol (SABA)?

A

CV effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which 3 SABA have the risk of causing paradoxical bronchospasm and CV effects?

A

Albuterol
Metaproterenol
Levalbuterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which 3 SABA have the risk of causing paradoxical bronchospasm?

A

Albuterol
Metaproterenol
Levalbuterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

LABA are more often used in the treatment of COPD. If they are used in patients with asthma, what must that patient be using too?

A

Asthmatic patients must also be using an ICS!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

In order for LABAs to be used with Asthma patients, what must they also be using?

A

ICS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Why must patients with asthma be using an ICS in order to use a LABA?

A

Increases the risk of asthma related deaths if not using an ICS as well

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

MOA for Anticholinergic drugs?

A

Block Acetylcholine from binding its receptors => bronchodilation by (-) parasympathetics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which Anticholinergic drug is used for a TEMPORARY blockade of muscarinic effects?

A

Atropine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

In patients with CAD, what must the Atropine dose be less than and why?

A

Less than 2-3 mg to avoid an increased HR and myocardial oxygen demand

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which Anticholinergic drug is used for the maintenance treatment of Bronchospasm?

A

Ipratropium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is unique about Ipratropium?

A

It is poorly absorbed so it is relatively free of systemic atropine-like side effects!!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which 2 Anticholinergic drugs are used for the LONG-term maintenance of bronchospasm?

A

Tiotropium

Aclidinium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which 2 Anticholinergic drugs are used for the long-term maintenance of bronchospasm?

A

Tiotropium

Aclidinium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What are the 2 MOAs for Theophylline (methylxanthine)?

A
  1. Bronchodilation

2. Suppresses airway response to stimuli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What conditions can Methylxanthines possible exacerbate?

A

PUD
Seizure disorders
Cardiac arrhythmias

22
Q

Which Methylxanthine can bronchodilate and suppress airway response to stimuli?

A

Theophylline

23
Q

What class of drugs is the most effective controller of Asthma?

A

ICS

24
Q

ICS decrease what cells?

A

Eosinophils
Mast cells
T lymphocytes

25
Q

MOA for ICS?

A

Turn off transcription of genes that encode inflammatory proteins

26
Q

MOA for ICS?

A

Turn off transcription of genes that encode inflammatory proteins

27
Q

For patients with persistent asthma, what is the 1st line therapy and what can you add after that?

A

ICS

+/- LABA

28
Q

With what 2 drugs must you be careful when switching them off a systemically active corticosteroid to the ICS?

A

Beclomethasone

Triamcinolone

29
Q

Why must you be careful when switching patients off a systemically active corticosteroid to either Beclomethasone or Triamcinolone?

A

Deaths due to adrenal insufficiency have occurred

30
Q

What 2 ICS drugs should patients who have a hypersensitivity to milk proteins avoid?

A

Budesonide

Mometasone

31
Q

What 2 ICS drugs should patients with a hypersensitivity to milk proteins avoid?

A

Budesonide

Mometasone

32
Q

Ciclesonide is a ____ that is (+) by _____

A

Prodrug

(+) bronchial esterases

33
Q

Since Ciclesonide is a prodrug, what does that decrease the risk of?

A

Candidiasis

34
Q

Flunisolide may reduce the need for what drug?

A

ORAL corticosteroids

35
Q

Triamcinolone may reduce the need for what drug?

A

Systemic corticosteroids

36
Q

What is a possible adverse effect of Fluticasone and what should patients do after drug use?

A

Candida Albicans infection of mouth/pharynx

– have patients rinse mouth after use

37
Q

ICS drugs are NOT to be used in what conditions?

A

Status asthmaticus or severe acute asthma

38
Q

ICS drugs are NOT to be used in what conditions?

A

Status asthmaticus or severe acute asthma

39
Q

Oral corticosteroids are more likely to cause what compared to ICS?

A

Side effects

40
Q

To treat asthma flare-ups, what can be added to a SABA?

A

Oral corticosteroid

41
Q

Prednisone adverse effect?

A

Hypothalamic-Pituitary-Adrenal axis suppression

42
Q

Patients on prednisone should be monitored for what?

A

Cushings Syndrome and hyperglycemia

43
Q

MOA of Leukotriene Antagonists?

A

Block CysLT receptors and their subsequent inflammatory cascade

44
Q

Montelukast blocks what receptor and what specific Leukotriene from performing its actions?

A

CysLT1 receptor

– LTD4

45
Q

Zafirlukast blocks the actions of what leukotrienes?

A

LTD4 and E4

46
Q

What is an adverse effect of Zafirlukast?

A

Hepatotoxcity

47
Q

Zileuton is a lipoxygenase (-) which means it blocks for the formation of?

A

All leukotrienes - LTB4, C4, D4, E4

48
Q

In what condition is Zileuton controlled release form NOT recommended?

A

Liver disease and elevated liver enzymes 3X ULN

49
Q

What type of Antibody is Omalizumab and what does a patient have to have in order to be placed on it?

A

Anti-IgE antibody

  • (+) skin test OR
  • reactivity to perennial aeroallergen
50
Q

Adverse effect of Omalizumab?

A

Anaphylaxis

2 - CPR (pulmonary) (26 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions