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2 - CPR (pulmonary) > Drugs for Pulmonary Artery Hypertension > Flashcards

Drugs for Pulmonary Artery Hypertension Flashcards

1
Q

What are 4 Prostanoids?

A

Epoprostenol
Treprostinil
Iloprost
Selexipag

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2
Q

What are 4 Prostanoids?

A

Epoprostenol
Treprostinil
Iloprost
Selexipag

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3
Q

What are 3 Endothelin Antagonists?

A

Bosentan
Ambrisentan
Macicentan

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4
Q

What are 3 Endothelin Antagonists?

A

Bosentan
Ambrisentan
Macicentan

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5
Q

What are 2 Phosphodiesterase 5 Inhibitors?

A

Sildenafil

Tadalafil

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6
Q

What are 2 PDE5 (-)’s?

A

Sildenafil

Tadalafil

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7
Q

What is 1 Guanylate Cyclase Sensitizer?

A

Riociguat

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8
Q

What is 1 Guanylate Cyclase Sensitizer?

A

Riociguat

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9
Q

If a (+) vasopressor test is present, what should you add?

A

CCB

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10
Q

Is there a cure for PAH?

A

No - treat symptoms and slow disease progression

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11
Q

What is the MOA for Prostanoids?

A

Prostacyclin analogs that increase cAMP
= vascular relaxation and
(-) smooth m. growth/platelet aggregation

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12
Q

How is Epoprostenol given and what is its half life?

A

Continuous IV pump and must be cold

- Half life = 6 mins

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13
Q

What are the common side effects of Epoprostenol?

A

N/V, headache, flushing and jaw pain

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14
Q

Treprostinil can be given many ways. When it is given via subcutaneous infusion, what side effect results?

A

Pain

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15
Q

When Treprostinil is given via continuous IV pump, what is its half life and temperature compared to Epoprostenol?

A

Half life is longer = 4 hours
DOES NOT have to be cold!!
– Epoprostenol: 6 min half life and must be cold

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16
Q

In what other 2 forms besides infusions is Treprostinil available?

A

QID inhalation

Extended release oral form

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17
Q

What are the side effects of the QID inhalation form of Treprostinil?

A

Cough, throat irritation and headache

18
Q

What are the side effects of Treprostinil?

A

Jaw pain, diarrhea, edema, N/V

19
Q

With the Prostanoids that are given via infusion, what adverse effect can occur due to the chronic catheter?

A

Sepsis or other life threatening events if catheter clogs

20
Q

How is Iloprost given?

A

Inhaled 6-9 times a day

21
Q

What are the common side effects with Iloprost?

A

Hypotension fainting, cough, flushing, jaw pain, headache

22
Q

How is Selexipag given?

A

ORAL twice a day

23
Q

What is the con about Selexipag?

A

It is oral in form but is EXPENSIVE

24
Q

What are the common side effects of Selexipag?

A

N/V, flushing, jaw/limb pain and rash

25
Q

MOA for Bosentan?

A

Blocks ETa and ETb endothelin receptors

26
Q

Serious adverse effects of Bosentan?

A

Hepatotoxicity and Teratogenesis

27
Q

Bosentan accelerates the metabolism of what things?

A

Warfarin

Oral contraceptives

28
Q

MOA for Ambrisentan?

A

Blocks ETa endothelin receptors only

29
Q

Serious adverse effect of Ambrisentan?

A

Teratogenesis

30
Q

Does Ambrisentan accelerate the metabolism of warfarin and oral contraceptives like Bosentan?

A

NO

31
Q

With Bosentan and Ambrisentan, what should the patient make sure that they do with their significant other?

A

Use 2 forms of birth control

32
Q

MOA and half life time for Macitentan

A

Blocks ETa and ETb

– Half life is 18 hours

33
Q

MOA for PDE5 inhibitors?

A

(-) PDE-5 to (-) cGMP breakdown and prolong smooth muscle relaxation

34
Q

Which PDE-5 inhibitor has a longer half life?

A

Tadalafil

35
Q

Adverse effects of Sildenafil?

A

Headache, dyspepsia, flushing and extended erections

36
Q

Sildenafil is what advertised drug?

A

Viagra

37
Q

MOA for Riociguat?

A

Increases NO and cGMP = vasodilation

38
Q

What are the adverse effects of Riociguat?

A

Fetal harm, hypotension, dyspepsia and headache

39
Q

What is a common drug combination for PAH?

A

Tadalafil + Ambrisentan

40
Q

What is a common drug combination for PAH?

A

Tadalafil + Ambrisentan

2 - CPR (pulmonary) (26 decks)

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