Antiviral Drugs - cardiopulm. infections Flashcards
What are 2 vaccines for the prevention of Streptococcus Pneumoniae?
Prevnar 13
Pneumovax 23
What are 2 vaccines for the prevention of Streptococcus Pneumoniae?
Prevnar 13
Pneumovax 23
What is the best Influenza prevention?
Influenza “flu” Vaccine
Are there any effective drugs for viral pneumonia due to Adenovirus, Parainfluenza or Respiratory Syncytial Virus?
NO
Influenza treatments are NOT substitutes for?
The Flu Vaccine
What are the 4 Influenza treatments?
Oseltamivir
Zanamivir
Peramivir
Baloxavir
What are the 4 Influenza treatments?
Oseltamirvir
Zanamivir
Peramivir
Baloxavir
MOA for Oseltamivir, Zanamivir and Peramivir?
(-) Neuraminidase to interfere with virion budding from the host cell
What are the common adverse effects of Oseltamivir?
N/V, warnings if chronic organ disease
How is Oseltamivir given?
Orally
How is Zanamivir given?
Oral inhalation
What are the common adverse effects of Zanamivir?
Bronchospasm and coughing risk
How is Peramivir given and what does that do to the half life?
IV - longer half life
MOA for Baloxavir?
(-) endonuclease activity to block viral replication
Baloxavir is a prodrug. What convert it to its active state?
UGT1A3
CYP3A4
What is a common adverse effect of Baloxavir and when is it not used?
- Diarrhea
- Not used in pregnancy
What is another drug that is no longer recommended, but was used for Influenza A only?
Amantadine
Amantadine is no longer recommended. What strain of Influenza was it used for and what is used for today?
Influenza A
– Now used for Parkinson Disease
The drugs to treat Influenza are used for what 2 purposes?
- Speed up recovery by 1-2 days
- Prophylaxis for those at high risk for complications
The drugs to treat Influenza are used for what 2 purposes?
- Speed up recovery by 1-2 days
- Prophylaxis for those at high risk for complications
