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2 - CPR (pulmonary) > Respiratory Pathology - 3 (pneumoconiosis/PVD) > Flashcards

Respiratory Pathology - 3 (pneumoconiosis/PVD) Flashcards

1
Q

What is Pneumoconiosis?

A

Reaction by the lungs to inhaled material

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2
Q

Reaction by the lungs to inhaled material

A

Pneumoconiosis

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3
Q

When will Pneumoconiosis be worse?

A
  • High and repetitive exposure to small particle sizes

- Smoking = impaired ciliary clearance

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4
Q

When will Pneumoconiosis be worse?

A
  • High and repetitive exposure to small particle sizes

- Smoking = impaired ciliary clearance

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5
Q

What are 3 types of Pneumoconiosis?

A
  1. Coal Workers’ Pneumoconiosis
  2. Silicosis
  3. Asbestosis
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6
Q

What are 3 types of Pneumoconiosis?

A
  1. Coal Workers’ Pneumoconiosis
  2. Silicosis
  3. Asbestosis
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7
Q

Coal Workers’ Pneumoconiosis is due to inhaled?

A

Coal dust

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8
Q

What can be some findings with Coal Workers’ Pneumoconiosis?

A

Anthracosis
Coal nodules
Progressive fibrosis

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9
Q

What will be present on histology images and gross images of the lungs with Coal Workers’ Pneumoconiosis?

A

Dark pigment

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10
Q

Is coal workers’ pneumoconiosis usually progressive?

A

NO

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11
Q

Silicosis is due to inhaled?

A

Silicon Dioxide

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12
Q

What are some jobs that could involve inhaling silicon dioxide?

A

Mining

Concrete work

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13
Q

What is seen on histology with Silicosis?

A

Dense collagenous nodules

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14
Q

What type of onset and progression does Silicosis have?

A

Insidious onset

– Progresses to massive fibrosis or cancer

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15
Q

What is seen on a radiograph with Silicosis?

A

Eggshell calcifications

calcified hilar lymph nodes

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16
Q

Eggshell calcifications of the hilar lymph nodes is seen with?

A

Silicosis

17
Q

Asbestosis is due to inhaled?

A

Asbestos fibers

18
Q

Which Asbestos fibers are more dangerous because they are inhaled deeper?

A

Amphibole

19
Q

Asbestosis affects the pleura and the lungs. What are those findings?

A 
Pleura = fibrosis, effusions, mesothelioma
Lung = interstitial fibrosis, carcinoma
20
Q

What specific thing will be seen on histology with Asbestosis?

A

Ferruginous bodies with macrophages attempting degradation

21
Q

Candlewax drippings of hyalinized collagen can be seen on the pleura with what?

A

Asbestosis plaques

22
Q

With a pulmonary embolism, what shape are the infarcts and what do they progress to?

A

Wedge shaped

- Start as hemorrhagic –> fibrosis

23
Q

How can you tell when an embolism occurred?

A

Lines of Zahn = Antemortem

24
Q

Lines of Zahn

A
  • Tell that a clot occurred while the patient was alive (antemortem)
    = alternating areas of red and pale
25
Q

When will bone marrow/fat emboli be seen?

A

Trauma

26
Q

What is a type of septic emboli that can cause an embolus?

A

Infective endocarditis – valve vegetations break off and can occlude vessels

27
Q

Air, foreign materials and parasites can also cause vessel obstruction. What type of embolism can be seen with IV drug users?

A

Talc embolism

– also septic embolism with infective endocarditis

28
Q

What defines Pulmonary Hypertension?

A

Pulmonary Artery Pressure > 20 mmHg

29
Q

What defines Pulmonary Hypertension?

A

Pulmonary Artery Pressure > 20 mmHg

30
Q

What is a very characteristic lesion seen with Pulmonary Hypertension?

A

Plexiform lesion

31
Q

What is a subjective thing seen with Pulmonary Hypertension?

A

Medial Hypertrophy

32
Q

When is a Plexiform lesion seen?

A

Pulmonary Hypertension

33
Q

What is a common pulmonary hemorrhage syndrome?

A

Goodpasture syndrome

34
Q

What type of immunofluorescence will be seen with Goodpasture Syndrome?

A

Linear

35
Q

What age/damage will patients with Goodpasture Syndrome present with?

A

Males 20-30s with lung and kidney damage

36
Q

Goodpasture Syndrome has antibodies to?

A

Non-collagenous subunit of collagen IV

Anti-basement membrane deposition

2 - CPR (pulmonary) (26 decks)

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