Drugs for ILD

Question 1

What are 5 drugs used to treat ILDs?

Answer 1

Prednisone
Mycophenolate
Methotrexate
Azathioprine
Nintedanib

Question 2

What are 5 drugs used to treat ILDs?

Answer 2

Prednisone
Mycophenolate
Methotrexate
Azathioprine
Nintedinab

Question 3

What are 5 drugs used to treat ILDs?

Answer 3

Prednisone
Mycophenolate
Methotrexate
Azathioprine
Nintedinab

Question 4

All of these drugs are what type of drugs?

Answer 4

Immunosuppressive

Question 5

What is an adverse effect of Prednisone and what should you watch for?

Answer 5

Hypothalamic-pituitary-adrenal axis suppression

- Monitor for Cushings Syndrome and Hyperglycemia with chronic use

Question 6

What are 2 indications for use of Mycophenolate?

Answer 6

• Rheumatoid Arthritis

- Prevention of organ transplant rejection

Question 7

What is the black box warning for Mycophenolate?

Answer 7

Embryofetal toxicity
Malignancies - lymphoma and skin
Infections

Question 8

Myocophenylate can cause what things in the 1st trimester of pregnancy?

Answer 8

Miscarriage

Fetal harm

Question 9

What reduces the efficacy of Mycophenolate?

Answer 9

Antacids

Question 10

Mycophenolate reduces the efficacy of?

Answer 10

Oral contraceptives

Question 11

What are 3 indications for Methotrexate?

Answer 11

1. Neoplastic diseases
2. Rheumatoid Arthritis
3. Psoriasis

Question 12

What are 2 contraindications for taking Methotrexate?

Answer 12

1. Pregnancy

2. Liver disease/alcoholism

Question 13

Methotrexate and NSAIDs may cause?

Answer 13

Hematologic and GI toxicities

Question 14

What drugs decrease Methotrexate absorption and renal clearance respectively?

Answer 14

Oral antibiotics

Penicillins

Question 15

Methotrexate decreases the clearance of?

Answer 15

Theophylline

Question 16

Side effects of Methotrexate are related to?

Answer 16

Dose and frequency of administration

Question 17

What are the 2 contraindications for taking Methotrexate?

Answer 17

1. Pregnancy

2. Liver diseases/alcoholism

Question 18

What are the 3 indications for taking Methotrexate?

Answer 18

1. Neoplastic diseases
2. Rheumatoid Arthritis
3. Psoriasis

Question 19

What are 2 indications for use of Azathioprine?

Answer 19

1. Rheumatoid Arthritis

2. Prevention of rejection in renal homotransplantation

Question 20

What is the contraindication for Azathioprine?

Answer 20

Pregnancy

Question 21

What are the main adverse effects caused by Azathioprine?

Answer 21

Hematologic and GI effects

Question 22

What is the black box warning for Azathioprine?

Answer 22

Malignancy

Question 23

MOA for Nintedanib?

Answer 23

Kinase Inhibitor

Question 24

Which drug is a Kinase Inhibitor?

Answer 24

Nintedinab

Question 25

What is Nintedanib used for?

Answer 25

Idiopathic Pulmonary Fibrosis

Question 26

What drug treats Idiopathic Pulmonary Fibrosis?

Answer 26

Nintedinab

Question 27

What things increase Nintedanib exposure?

Answer 27

P-gy and CYP3A4 inhibitors

Question 28

What are the common side effects of Nintedinab?

Answer 28

N/V, diarrhea, elevated liver enzymes, HTN, weight loss

Question 29

What are 4 serious adverse effects caused by Nintedinab?

Answer 29

Embryofetal toxicity
Bleeding
Thrombi
GI perforation

Question 30

What are common side effects and serious adverse effects caused by Nintedanib?

Answer 30

Commonly:
- N/V, diarrhea, HTN, weight loss and elevated liver enzymes
Serious Effects:
- Embryofetal toxicity, bleeding, thrombi, GI perforation