Antifungal/Anti-TB - cardiopulm. infections

Question 1

What are 2 common invasive fungal infections?

Answer 1

Candida

Aspergillus

Question 2

What are 2 common invasive fungal infections?

Answer 2

Candida

Aspergillus

Question 3

MOA for Amphotericin B?

Answer 3

Forms pores in the fungal cell membranes

Question 4

MOA for Amphotericin B?

Answer 4

Forms pores in the fungal cell membranes

Question 5

Possible adverse effects with Amphotericin B?

Answer 5

GI distress
Nephrotoxicity
Electrolyte disturbances
Leukoencephalopathy

Question 6

Possible adverse effects with Amphotericin B?

Answer 6

GI distress
Electrolyte disturbances
Nephrotoxicity
Leukoencephalopathy

Question 7

MOA for “-nazoles”

- Fluconazole, Voriconazole, Itraconazole?

Answer 7

(-) conversion of lanosterol to Ergosterol

Question 8

Which -nazole has excellent activity against yeasts but NOT molds?

Answer 8

Fluconazole

Question 9

What is the adverse effect that is associated with all of the -nazoles?

Answer 9

Hepatotoxicity

Question 10

When is Voriconazole used?

Answer 10

Invasive Aspergillosis

Fluconazole - resistant Invasive Candidiasis

Question 11

What are the extra unique adverse effects associated with Voriconazole besides hepatotoxicity?

Answer 11

Transient vision changes

Visual hallucinations

Question 12

This - nazole is also active against aspergillosis, blastomycosis and histoplasmosis

Answer 12

Itraconazole

Question 13

What is the extra unique side effect with Itraconazole besides hepatoxicity?

Answer 13

Negative inotropic effects

= exacerbate/cause heart failure

Question 14

What are the -nazoles that are the antifungals?

Answer 14

Fluconazole
Voriconazole
Itraconazole

Question 15

MOA for Caspofungin and Micafungin?

Answer 15

(-) beta - D - glucan synthesis to weaken cell wall

Question 16

MOA for Flucytosine?

Answer 16

Interferes with purine and pyrimidine fungal metabolism

Question 17

What does Flucytosine required extreme caution with?

Answer 17

Patients with renal impairment

– monitor renal, hepatic and hematologic status

Question 18

What are the 7 Antifungal treatments for Candida and Aspergillus?

Answer 18

Amphotericin B
Fluconazole
Voriconazole
Itraconazole
Caspofungin
Micafungin
Flucytosine

Question 19

What are the 4 Anti-Tuberculosis treatments?

Answer 19

Isoniazid
Rifampin
Pyrazinamide
Ethambutol

Question 20

What are the 4 Anti-Tuberculosis drugs?

Answer 20

Isoniazid
Rifampin
Pyrazinamide
Ethambutol

Question 21

What drugs for Tuberculosis is active against active and latent infections?

Answer 21

Isoniazid

Rifampin

Question 22

What are the adverse effects with Isoniazid?

Answer 22

Hepatitis

Peripheral Neuropathy

Question 23

What age group is at peak vulnerability from hepatitis due to Isoniazid for TB?

Answer 23

50-64

Question 24

For those at an increased risk to develop peripheral neuropathy from Isoniazid for TB, what should be given to them daily?

Answer 24

100 mg of Pyridoxine

Question 25

Rifampin and Isoniazid can both treat?

Answer 25

Active and Latent TB

Question 26

Adverse effects of Pyrazinamide?

Answer 26

Hepatotoxicity
Athropathy
Rash

Question 27

What drug for TB is hepatotoxic?

Answer 27

Pyrazinamide

Question 28

What is the adverse effect of Ethambutol when treating TB?

Answer 28

Visual disturbances

Question 29

This drug for TB can cause visual disturbances?

Answer 29

Ethambutol