Respiratory Flashcards

1
Q

Formoterol

A

Long acting beta2 agonist

Relax bronchial smooth muscle by stimulating beta2 adrenoreceptors.

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2
Q

Indacaterol

A

Long acting beta2 agonist

Relax bronchial smooth muscle by stimulating beta2 adrenoreceptors.

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3
Q

Salbutamol

A

Short acting beta2 agonist

Relax bronchial smooth muscle by stimulating beta2 adrenoreceptors.

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4
Q

Salmeterol

A

Long acting beta2 agonist

Relax bronchial smooth muscle by stimulating beta2 adrenoreceptors.

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5
Q

Terbutaline

A

Short acting beta2 agonist

Relax bronchial smooth muscle by stimulating beta2 adrenoreceptors.

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6
Q

Aclidinium

A

Long acting muscarinic antagonist

Promote bronchodilation by inhibiting cholinergic bronchomotor tone. They block muscarinic actions of acetylcholine.

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7
Q

Glycopyrronium

A

Long acting muscarinic antagonist

Promote bronchodilation by inhibiting cholinergic bronchomotor tone. They block muscarinic actions of acetylcholine.

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8
Q

Ipratropium

A

Short acting muscarinic antagonist

Promote bronchodilation by inhibiting cholinergic bronchomotor tone. They block muscarinic actions of acetylcholine.

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9
Q

Tiotropium

A

Long acting muscarinic antagonist

Promote bronchodilation by inhibiting cholinergic bronchomotor tone. They block muscarinic actions of acetylcholine.

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10
Q

Umeclidinium

A

Long acting muscarinic antagonist

Promote bronchodilation by inhibiting cholinergic bronchomotor tone. They block muscarinic actions of acetylcholine.

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11
Q

Aminophylline

A

Theophylline

Not entirely understood. Possible effects include bronchial smooth muscle relaxation, anti-inflammatory effects, increase in diaphragm contractility and CNS stimulation.

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12
Q

Theophylline

A

Theophylline

Not entirely understood. Possible effects include bronchial smooth muscle relaxation, anti-inflammatory effects, increase in diaphragm contractility and CNS stimulation.

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13
Q

Beclometasone (Inhaled)

A

ICS

Reduce airway inflammation and bronchial hyper-reactivity.

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14
Q

Budesonide (Inhaled)

A

ICS

Reduce airway inflammation and bronchial hyper-reactivity.

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15
Q

Ciclesonide (Inhaled)

A

ICS

Reduce airway inflammation and bronchial hyper-reactivity.

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16
Q

Fluticasone furoate (Inhaled)

A

ICS

Reduce airway inflammation and bronchial hyper-reactivity.

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17
Q

Fluticasone proprionate (Inhaled)

A

ICS

Reduce airway inflammation and bronchial hyper-reactivity.

18
Q

Mometasone (Inhaled)

A

ICS

Reduce airway inflammation and bronchial hyper-reactivity.

19
Q

Vilanterol

A

Ultra-Long acting beta2 agonist

Relax bronchial smooth muscle by stimulating beta2 adrenoreceptors.

20
Q

Olodaterol

A

Long acting beta2 agonist

Relax bronchial smooth muscle by stimulating beta2 adrenoreceptors.

21
Q

Benralizumab

A

Binds to and blocks the interleukin‑5 receptor (expressed on eosinophils and basophils), reducing the production and survival of eosinophils. Benralizumab also induces eosinophil (and basophil) apoptosis.

22
Q

Dupilumab

A

Inhibits activity of the cytokines interleukin‑4 and ‑13, which are involved in atopic inflammatory and immune responses.

23
Q

Mepolizumab

A

Binds to interleukin‑5 (IL‑5), reducing the production and survival of eosinophils.

24
Q

Montelukast

A

Inhibits the cysteinyl leukotriene receptor; antagonises airway smooth muscle contraction and inflammation caused by leukotrienes.

25
Q

Omalizumab

A

Binds to immunoglobulin E (IgE), reducing the immune system’s response to allergen exposure.

26
Q

Codeine (respiratory)

A

Mu opioid receptor agonist

Opioid derivatives; they depress the medullary cough centre.

27
Q

Dextromethorphan

A

Mu opioid receptor agonist

Opioid derivatives; they depress the medullary cough centre.

28
Q

Dihydrocodeine

A

Mu opioid receptor agonist

Opioid derivatives; they depress the medullary cough centre.

29
Q

Acetylcysteine (Inhaled)

A

Mucolytic

Reduces mucus viscosity by splitting disulfide bonds in mucoproteins.

30
Q

Bromhexine

A

Mucolytic

Reduces mucus viscosity

31
Q

Dornase alfa

A

Mucolytic

Reduces mucus viscosity in cystic fibrosis by cleaving extracellular DNA.

32
Q

Elexacaftor

A

Increase the amount and function of cystic fibrosis transmembrane conductance regulator (CFTR) protein on the cell surface.

33
Q

Lumacaftor

A

Increases the amount and function of cystic fibrosis transmembrane conductance regulator (CFTR) protein on the cell surface

34
Q

Tezacaftor

A

Increase the amount and function of cystic fibrosis transmembrane conductance regulator (CFTR) protein on the cell surface.

35
Q

Ivacaftor

A

Increases channel opening of the CFTR protein to facilitate chloride ion transport across cell membranes.

36
Q

Mannitol

A

Mucolytic

Hyperosmotic; it draws fluid into the airway and increases mucus hydration which reduces its viscosity and eases expectoration.

37
Q

Beractant

A

Pulmonary surfactant

Lower alveolar surface tension and increase lung compliance.

38
Q

Poractant alfa

A

Pulmonary surfactant

Lower alveolar surface tension and increase lung compliance.

39
Q

Cacffeine

A

May stimulate the respiratory centre, increasing the rate and depth of respiration.

40
Q

Pirfenidone

A

Exact mode of action is unknown. In animal models, it inhibits the release of pro-inflammatory and profibrotic cytokines, and inhibits the proliferation of lung fibroblasts.