Anticoagulants

Question 1

Dalteparin

Answer 1

Low molecular weight Heparin

Inactivate clotting factors IIa (thrombin) and Xa by binding to antithrombin III; LMWHs and danaparoid have a much greater effect on factor Xa than on thrombin. Danaparoid is a more selective inhibitor of factor Xa than LMWHs.

Question 2

Danaparoid

Answer 2

Heparin

Inactivate clotting factors IIa (thrombin) and Xa by binding to antithrombin III; LMWHs and danaparoid have a much greater effect on factor Xa than on thrombin. Danaparoid is a more selective inhibitor of factor Xa than LMWHs.

Question 3

Enoxaparin

Answer 3

low molecular weight Heparin

Inactivate clotting factors IIa (thrombin) and Xa by binding to antithrombin III; LMWHs and danaparoid have a much greater effect on factor Xa than on thrombin. Danaparoid is a more selective inhibitor of factor Xa than LMWHs.

Question 4

Heparin/ unfractionated heparin

Answer 4

Heparin

Inactivate clotting factors IIa (thrombin) and Xa by binding to antithrombin III; LMWHs and danaparoid have a much greater effect on factor Xa than on thrombin. Danaparoid is a more selective inhibitor of factor Xa than LMWHs.

Question 5

Bivalirudin

Answer 5

Direct thrombin inhibitor

Reversibly inhibit both free and fibrin-bound thrombin, preventing conversion of fibrinogen to fibrin, preventing thrombus formation. Thrombin-induced platelet aggregation is also inhibited.

Question 6

Dabigatran

Answer 6

Direct thrombin inhibitor

Reversibly inhibit both free and fibrin-bound thrombin, preventing conversion of fibrinogen to fibrin, preventing thrombus formation. Thrombin-induced platelet aggregation is also inhibited.

Question 7

Warfarin

Answer 7

Vitamin K antagonist; inhibits synthesis of vitamin K-dependent clotting factors (II, VII, IX, X) and the antithrombotic factors protein C and protein S.

Question 8

Apixaban

Answer 8

Factor Xa inhibitor

Selectively inhibit factor Xa, blocking thrombin production, conversion of fibrinogen to fibrin, and thrombus development.

Question 9

Fondaparinux

Answer 9

Factor Xa inhibitor

Selectively inhibit factor Xa, blocking thrombin production, conversion of fibrinogen to fibrin, and thrombus development.

Question 10

Riveroxaban

Answer 10

Factor Xa inhibitor

Selectively inhibit factor Xa, blocking thrombin production, conversion of fibrinogen to fibrin, and thrombus development.