Resp 7 Flashcards
what would a PO2 as low as 20 mmHg in a. tissue result in
large release of O2 by hemoglobin
what are the effects of pH on hemoglobin
more acid (a lower pH) will shift the curve to the right
what does shifting hemoglobins curve to the right mean
that it has lowered affinity
what is the Bohr affect
the reduced ability of hemoglobin to hold onto O2
what are the effects of CO2 on hemoglobin
more CO2 will shift the curve to the right
what is CO2 readily converted to
acid
what are the effects of temperature on hemoglobin
as temp increases, the curve shifts to the right
what are the effects of 2,3-BPG on hemoglobin
more of it will shift it to the right
what is a by product of glycolysis in RBC’s
2,3-BPG
what is special about fetal hemoglobin
it has a higher affinity for O2 then maternal hemoglobin
whats the build of fetal hemoglobin
2 alpha and 2 gamma
whats the purpose of fetal hemoglobin having a higher affinity for O2`
ensures adequate amount of saturation at low O2 levels
how much CO2 is dissolved in plasma
7%
how much CO2 goes into red blood cells
93%
how much CO2 binds to hemoglobin in RBCs
23%
how much CO2 is converted to HCO3 (bicarbonate) in RBCs
70%
is excess CO2 bad for you
it can cause acidosis and interruptions in hydrogen bonds/protein denaturation
what is the purpose of CO2 being converted to bicarbonate (2)
provides an additional CO2 transport
bicarbonate acts as a buffer for metabolic acids to stabilize pH
what enzyme converts CO2 and H2O to bicarbonate
carbonic anhydrase
what 2 mechanisms ensure that equilibrium is not reached by removing HCO3 and H+
- bicarbonate chloride exchanger removes bicarbonate from cytosol
- hemoglobin acts a buffer for H+
can hemoglobin bind CO2
yes
