Renal 2 Flashcards
what is the renal corpuscle
multiple structures that are involved in the filtration unit
what are podocytes
specialized epithelial cells that surround glomerular cells
what is a mesangial cell
connective tissue (support cells)
what consists of the triple filtration barrier
capillary endothelial cells
basal lamina
podocyte end feet
what are capillary endothelial cells
fenestrated pores
what is the basal lamina
an extracellular matrix (mesh)
what are podocyte end feet
the last filtration slit to go through in the Bowmans capsule
what can mesangial cells influence and how
they can influence filtration by altering surface area for filtration
what are mesangial cells a part of
the renal corpuscle
what pressure/s favour filtration
hydrostatic
what pressure/s opposes filtration
colloid osmotic
Bowmans capsule hydrostatic pressure
what is the glomerular filtration rate
the volume of fluid that filters from the glomerular capillaries into the Bowmans capsules per unit time
how much fluid is filtered each day
125ml/min or 180L/day
what are the 2 factors that influence GFR
filtration pressure
how permeable the triple filtration barrier is
if there was no reabsorption, how fast would we run out of plasma
24 minutes
is GFR relatively constant
yes
what is GFR primarily regulated by
renal arterioles, primarily afferent arteriole
is reabsorption 100%
never
what is renal blood flow overall dependant on
overall resistance
what does GFR regulation do
helps to keep GFR stable when there is high blood pressure
what are the 2 auto regulation mechanisms
myogenic auto regulation
tubuloglomerular feedback
what is myogenic autoregulation
when the arteriole contracts in response t the street of vascular smooth muscle due to increased blood flow
what is tubuloglomerular feedback
the nephron loops back on itself in between the afferent and efferent arterioles where the macula densa cells release paracrine that affect diameter of arterioles
where are macula dense cells located
on the ascending wall of the loop of henle
