Renal 5 Flashcards

1
Q

mass balance

A

whatever comes in must be excreted if not needed

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2
Q

what determines ECF volume and osmolarity

A

H2O and Na

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3
Q

what determines the bodies pH

A

H and HCO3

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4
Q

why is maintaining osmolarity within the body important

A

water can cross most cell membranes freely and easily affect cell volume

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5
Q

what kind of osmolarity are renal tubes always exposed to ? how do they deal with it

A

hypertonic ECF
thy produce organic solutes to match the intracellular osmolarity to the ECF

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6
Q

what systems does fluid and electrolyte balance use (4)

A

respiratory
cardiovascular
renal systems
behavioural responses

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7
Q

what systems are fast in the fluid and electrolyte balance equilibrium

A

cardiovascular
respiratory

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8
Q

what systems are slow in fluid and electrolyte balance control

A

renal

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9
Q

what control are the kidneys under

A

endocrine and neuroendocrine control

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10
Q

how much of water makes up our body weight

A

50-60%

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11
Q

what are the 2 ways water can be gained

A

food and drink
metabolism

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12
Q

how is water lost? (4)

A

skin
lungs
urine
feces

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13
Q

can the kidneys replace water that’s lost to the environment

A

no

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14
Q

how must volume loss be replaced

A

behavioural mechanisms to maintain homeostasis

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15
Q

what mainly controls production of urine

A

the renal medulla

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16
Q

what is the removal of excess urine called

A

diuresis

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17
Q

when removal of excess water is required, the kidneys produce large volume of

A

dilute urine

18
Q

if the kidneys need to conserve water, low volume of ________ _______ is produced

A

concentrated urine

19
Q

how do the kidneys control urine concentration

A

varying the mounts of water and Na reabsorbed in the distal nephron

20
Q

where is water reabsorbed

A

descending loop

21
Q

what allows water permeability but not solutes

A

descending loop

22
Q

what limb allows ion reabsorption but not water

23
Q

what does urine osmolarity depend on

A

reabsorption in the collecting duct

24
Q

what does vasopressin control

A

water reabsorption

25
with maximal vasopressin, the collecting duct is _____________ to water
permeable
26
with the absence of vasopressin, the collecting duct is __________ to water
impermeable
27
without vasopressin, pee is dilute or concentrated
dilute
28
what kind of hormone is vasopressin
antidiuretic hormone
29
how does vasopressin control water reabsorption
by signalling to insert aquaporin channels
30
whats the vasopressin receptor? where is it located
V2 receptor locate on the basolateral membrane
31
how is water absorbed into the blood
osmosis
32
what is the most potent stimulus of AVP
increased osmolarity (280mOsM)
33
what activates osmoreceptors ? (3)
increased osmolarity decreased blood pressure decreased blood volume
34
why does vasopressin show a circadian rhythm at night increasing it?
so we dont pee as much in the night
35
what produces and releases AVP
magnocellular neurosecretory cells
36
what is osmolarity monitored by
osmoreceptor neurons
37
when do stretch sensitive neurons increase their firing rate (osoreceptors)
when osmolarity increases (so the cell shrinks and vasopressin is needed to be created)
38
what signals to MNC's (2)
osmoreceptors baro and atrial receptors
39
where is AVP released from
posterior pituitary
40
In a state of diuresis the kidneys will produce
high volume of dilute urine