Renal 7 Flashcards
what do granual cells secrete
renin
what are the 3 stimuli for renin secretion
low blood pressure in renal arterioles
, increased sympathetic output, and ocular densa cell feedback
(all in response to low blood pressure)
what are granular cells also known as
juxtaglomerular cells
what is renins main role
convent an inactive plasma protein, angiotensinogen, into angiotensin I
what does the angiotensin converting enzyme do
converting angiotensin I into angiotensin II
where is angiotensin converting enzyme produced by
blood vessel of endothelium
what does angiotensin II do after being converted
travels to the adrenal cortex and stimulates production of aldosterone
what drives thirst
an increase in osmolarity
whats the purpose of increasing sodium reabsorption
when blood pressure is low, we want to bring more fluid in
what is ANGII goal
to increase blood pressure
what do pharmaceutical companies use for treatment of hypertension
ACE inhibitors (enzyme that cleaves ANGI to ANGII)
what does atrial natriuretic peptide do
promotes Na+ and water excretion when blood pressure gets too high
what is excessive loss of Na called
natriuresis
where is atrial natriuretic peptide produced and secreted from
myocardial cells in the atria of the heart
what signals myocardial cells to release atrial natriuretic peptide
increased blood volume that stretches the atria
what does the brain natriuretic peptide do
respond to increased blood volume
what does ANP do to the kidneys
increases GFR by relaxing afferent arterioles
what is AVP
vasopressin
what is ANP
atrial natriuretic peptide
when is ANP stimulated
high blood pressure
where is potassium reabsorbed
proximal tubule
ascending limb of loop of henle
where is potassium secreted
last distal tubule and initial collecting duct
how much K is excreted compared to filtered load
10-20% of filtered is excreted
does high [K] increase or decrease aldosterone release
increases
