Research And Eval Flashcards
What is the gold standard of research
RCT
What is the definition of Evidence Based Practice
The practice of health care in which the practitioner systematically finds, appraises, and uses the most current and valid research findings as the basis for clinical decisions
*Results in the best possible outcome for your patients**
What is a meta-analysis
Pools data and statistically interprets is from several studies
What is an efficacy trial
Attempts to learn if a drug, surgical procedure, or admin program works under ideal circumstances
What is the Pearson correlation
The most common measure of correlation
What is subject variation in measurement error
Variability of individual subjects
Like different answers on a survey
What is non differential miscalculation
When the bias is random or equally present in each group ( case vs control )
Does a chi square give any indication about the variable relationship strength
NO
What is a histogram,
Is a bar graph, comprised of a series of columns, each representing one score or class interval
What does a negative LR tell you
LR-
Is the proportion of diseased people with a negative test (1-sensitivity) divided by the proportion of non-diseased people with a negative test (specificity)
What kind of study is a BP Study
A normative study
What is evidence based medicine
To integrate clinical expertise with the best available evidence
What are three types of experimental research designs
RCTs, (gold standard)
Single subject
Quasi-experiments
What is non-experimental research
Refers to investigation that are generally more descriptive or exploratory in nature and that exhibit direct control over the studied variables
What is misclassification bias
Occurs when those that have the disease are mistakenly put in the control group
A random error is also know as
Chance variation
What are the four paradigm shifts which have emerged in healthcare
- evidence based practice
- focus on translational research
- conceptualization of health and disability
- importance of Inter professional collaboration
What it retrospective research
Examination of date that has been collected in the past
What biases are Systematic and meta anylsis subject to
Inclusion/ exclusion criteria
What is an example of a quantitative question
On a scale of 1-10 how is your pain
What are two types of measurement errors
Systematic errors: are predictable errors of measurement
Random errors: are due to chance and can effect a subjects measurement in a unpredictable way
What is a systematic review
Is a thorough, comprehensive, structured way of combining findings from several sources with an analysis of the methodological quality of the studies.,
It is an interpretation of the available medical literature
What is observer variation in measurement error
Variability of measurements based on the fatigue of the observer, variations in training
What intrarater reliability
Refers to the stability of data recorder by one individual across two or more trials
Do Cohort study’s develop relative risk
YES and Odds ratios
What does analytic research do
Analyzes associations
Investigates Relationships
TESTS hypotheses
What does a logistical regression do
Estimates the probability of an outcome associated with a dichotomous response for a single or multiple variables
What kind of research observe natural phenomenon
Observational
What is translational research
refers to the application of basic scientific findings to clinically relevant issues, and simultaneously, the generation of scientific questions based on clinical dilemmas.
What is a case report
A narrative in the professional literal that IDs a single incident and discusses pertinent factors related to the pt.
What is observational research
Phenomena are observed rather than manipulated
What is a paradigm
A set of assumptions, concepts, or values that make a framework for reality
-defines what questions are important
What is the formula for relative risk
EER
_____
CER
What is the fishers exact test
A non-parametric test, can be used with small or sparsely distributed data sets
What are the five study types of PICO questions
Therapy Diagnosis Prevention Etiology Prognosis
What minimizes bias
Empirical-ism
What is systems based practice
To asses, coordinate, and improve the silvery and effectiveness of health care and patient outcomes
What are two types of validity
Internal validity: within the confines of the study appear to be accurate and the interpretation of the results is supported
External Validity: result and interpretations of the study apply outside the studied population. Also called generalizability
What is social desire ability bias
People want to be seen in a favorable social light so they give more positive answers
If relative risk is less than 1
Negative associated, possibly protective
What is peer review
The process by which an authors peers and recognized researchers in the filled read and evaluate a paper submitted for publication
What are the steps to the research process
ID the research question (Who, what, how) Design the study Implement the study Analyze the data Disseminate the findings Close the loop (Replication/ additional research)
What defines professionalism
On going profesional development
What increases the strength of a case control study
Adding multiple controls
What is information bias
Occurs when the means for obtaining information about subjects in the study are inadequate so that as a result some of the information regarding the exposure or outcomes are incorrect
What is recall bais
Is the main form of information bias in case control studies
When there is a differntional recall of exposure between cases and controls
What is the measurement of outcomes triad
- Structure: Assessed through organization standards
- Process: Quality assurance programs
- Outcomes: Morbidity, mortality, length of stay, and readmissions
What is qualitative research
Naturalist, humanistic or idealistic approach to research
Explore a social or human problem
What do cross sectional studies determine
Prevalence NOT incidence
What is clinical research
Structures process of investigation facts and theories and exploring connections
-utilizes a variety of quantitative and qualitative measurement tools
What part of a study tells you if the results are valid or meaningful
The methods section
What is an example of a qualitative question
Tell me about your pain ?
What reduces measurement errors
- Double blinding
- Independent observers
- Validating instruments
- Providing supervised training
- Using multiple observers and data sources
If Relative Risk is equal to 1
No association
What are descriptive statistics uses for
To characterize the shape, central tendency, and variability within a diet of data, often with the inten to describe a population
What is absolute risk reduction
The actual reduction in events in the treated group
Is the TRUE DIFFERENCE between the experiment and the control intervention
What is survivor bias
Can lead to erroneros associations between an exposure and outcome based on survivorship of the subject in a study
What are the strengths of a cross sectional study
Can asses multiple outcomes and exposures simultaneously
Lead to further studies
Can generate prevalence
Can calculate odds ratios
What are case control studies
Studies in which patients who already have a specific condition (cases)are compared with people who do not (controls)
What is the purpose of a case-control study
To determine if the frequency of an exposure or certain personal characteristics are different for those who did/ did not get the disease
What are two general types of errors
Unpredictable
And errors made in a biased, systematic way
how do researchers use statistics
To estimate population parameters
Clinicians must be able to use what two types of sources
Primary and Secondary
Define internal validity
Within the confines of the study ,
Results appear to be accurate interpretations of the investigations supported
What is a recall bias
The possible inaccuracy of recalling medical history or previous exposures
What does a positive LR tell you
(LR+)
is the reaction of the proportion of diseased people with a positive test result (sensitivity) to the proportion of non-diseased people with a positive result (1-specificity)
What is the scientific method
Defines as the systematic, empirical, and controlled critical examination fo hypothetical propositions about the associations of natural phenomena
What are two types of date
Categorical and continuous
What is the number needed to treat
Expresses the likelihood of the treatment to benefit an individual patient
What are confounding variables
Variable that correlates directly or indirectly with the dependent and independent variables
What does covariate mean
An extraneous variable that is statistically controlled in an analysis of covariance, so that the relationship between the independent and dependent variables is analysed with the effects of the extraneous factor removed
What is quantitative research
Measurement of outcomes using numerical date under standardized conditions
What are case series used for
Examine adveres events or effects
Catalog new diseases or outbreaks
Determine safety of a new treatment
Discuss potential efficacy of a new treatment
A LR+…..
A LR-…
LR+ rules in the disease
LR- rules out a disease
What are filtered resources
Evaluate how recently the summary or study was updated of revised
Examples: clinical practice guidelines
Cochran Database of systematic Reviews
What kind of research is a cross sectional study
Observational
What is the dependent variable
AKA the outcome variable
Response of effect that is presumed to vary depending on the independent variable.,
What was the purpose of the Impact factor/ score
Was to support budgetary decisions of libraries, not to serve as a measure of scientific worth of individual studies
What is categorical data
Nominal data- classifications
Ordinal Data- ranked or sequenced data
What is longitudinal research
Follows a cohort of subjects over time, repeated measurements at prescribed intervals
What are measurements
Defined as the process of assigning numeral to variables to represent quantities of characteristics according to certain rules
What is scientific research
The process of investigation facts and theories in a scientific way to examine relationships among clínical phenomena to generat evidence for decision making
What are the strengths of a meta analyses
Generate great statistical power
Confirmatory data analysis
And ability to extrapolate the general population
What is inferential statistics
Involve a decision making process allowing estimation of population characteristics from sample data
What type of square test would you use if the date was in paired samples
McNemar test for matched pairs
What is the Alternative hypothesis
H_a or H_1
The statement that establishes a relationship between variables being assessed
What does the chi-square for equality of proportion test
Computed the same way as the CI square test for independence, but instead tests the hypothesis that the distribution of some variable in the same in all populations
What is exploratory research
Cohort studies
Case Control Studies
-used to examine phenomena of interés and how it relates to other factors