Repro Flashcards
Human chorionic gonadotropin
produced primarily by syncytiotrophoblastic cells of the placenta during pregnancy. The hormone stimulates the corpus luteum to produce progesterone to maintain the pregnancy.
miroestrol
phytoestrogen
almost as potent as estradiol in vitro and even more potent than estradiol when administered orally
Klaassen, Curtis D.. Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th Edition (p. 1028). McGraw-Hill Education. Kindle Edition.
Linuron
(Herbicide)
AR antagonist.
epididymal and testicular abnormalities
Klaassen, Curtis D.. Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th Edition (p. 1029). McGraw-Hill Education. Kindle Edition.
mechanisms of endocrine disrupting chemicals
binding to the estrogen receptor (ER), the AR, or retinoic acid (RAR, RXR) receptors, and by inhibition of steroidogenic enzymes or the synthesis of thyroid hormones.
Klaassen, Curtis D.. Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th Edition (p. 1028). McGraw-Hill Education. Kindle Edition.
Hershberger Assay
detects antiandrogenic activity simply by weighing androgen-dependent tissues in the castrated male rat
high sensitivity and specificity to chemicals with AR-mediated activity.
Klaassen, Curtis D.. Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th Edition (p. 1031). McGraw-Hill Education. Kindle Edition.
Reserpine, chlorpromazine, and monoamine oxidase (MAO) inhibitors
modify the content or actions of brain monoamines that affect gonadotropin production.
Klaassen, Curtis D.. Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th Edition (p. 1012). McGraw-Hill Education. Kindle Edition.
pulp and paper mill effluents
include a chemical mixture that binds to the AR and induces androgen-dependent gene expression in vitro.
masculinized female mosquitofish
Klaassen, Curtis D.. Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th Edition (p. 1029). McGraw-Hill Education. Kindle Edition.
