Advanced Topics Lecture

Question 1

Margin of Safety

Answer 1

ratio of the dose that is just within the toxic range (TD01) to the dose that is 99% effective (ED99)

MOS = TD01/ED99

Typically 10x

Question 2

Estimates based on POD

Answer 2

The reference dose (RfD), 
acceptable daily intake (ADI), 
tolerable daily intake (TDI), 
permitted daily exposure (PDE), 
and derived no effect level (DNEL) are all regulatory values indicating a risk-based acceptable level of exposure. 

They are derived from a point of departure (POD), which may be a NOAEL, LOAEL, or BMD(L), and various assessment/ uncertainty/safety factors (different names applied to equivalent factors in different regulatory schemes).

Question 3

Therapeutic Index

Answer 3

Compare the toxic dose to the therapeutically effective dose

TD50/ED50

Question 4

Margin of Exposure

Answer 4

for chemicals with no benefit

MOE = NOAEL/Human exposure

Question 5

MABEL

Answer 5

Minimally Anticipated Biologically Effective Level