Renal Physiology And Bp:Natriuretic Peptides Flashcards

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1
Q

Bp=

A

CO x TPR

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2
Q

CO=

A

SV x HR

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3
Q

What happens when you increase fluid volume?

A

Increase stroke volume which will increase cardiac output and therefore bp= increase flow of blood through the kidneys,increasing glomerular filtration rate

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4
Q

Prolonged periods of blood pressure can have what effect on the kidney?

A

Lead to damage in the kidneys
E.g. proteins being passed through when they shouldn’t

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5
Q

Release of natriuretic peptides in response to increase in CO? Have what effect ?

A

Increase production of urine to decrease SV
Vasodilation to reduce TPR
= overall will reduce CO, TPR AND BP

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6
Q

Natriuretic peptides define

A

Hormones released from the atria and ventricles in the heart in response to increased stretch of the heart

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7
Q

In healthy individual , increase in CO sensed by?

A

BARORECEPTORS In the heart

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8
Q

Types of Natriuretic peptides

A

Atrial Natriuretic peptide (ANP)
Brain Natriuretic peptide (BNP)

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9
Q

Natriuretic peptide receptors respond to what peptides? And mechanism

A

Respond to ANP and BNP
The receptors are linked to a Guanylate Cyclase enzyme: converts GTP to cyclic GMP which stimulates Protein Kinase A = causes vasodilation similar to PKA (activation of ion channels/ inhibition of contractile proteins )

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10
Q

Other function of Natriuretic peptide despite vasodilation?

A

Act to decrease Na reabsorption in the nephron: through inhibition of ENaC = which increase urine output
PROMOTES diuresis and naturesis

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11
Q

Natiuresis by Natriuretic peptides

A

Inhibits reabsorption of sodium in collecting duct and other segments of the nephron, increase Sodium excretion in the urine
= Lower SV

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12
Q

Diuresis by Natriuretic peptides

A

ANP dilates afferent arteriole + Vasodilating effects increase blood flow which will also increase excretion of urine
= lower sv

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