Pathophysiology Of Allergy Flashcards

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1
Q

Anaphylaxis define.

A

Severe systemic allergic reaction

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2
Q

Allergic diseases are characterised by inflammation activated by?

A

IgE

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3
Q

What initiates an allergic disease?

A

Underlying innate immune mechanisms

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4
Q

Resident vs infiltrating cells difference

A

Resident= are in particular tissues
Infiltrating = involved in inflammation by recruitment from the circulation

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5
Q

Blood cells can beactivated using signaling molecules which attract the cells to site of inflammation. How?

A
  1. Signalling molecules can be chemical attractants
    2 . Some are adhesive molecules
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6
Q

How might adhesive molecules attract the cells to site of inflammation?

A

Blood cells move across the walls of blood vessels and out into tissues where they gain access to other adhesion molecules, trapping infiltrating cells at tissue sites where needed

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7
Q

Mediator plus can be?

A

Preformed -stored within cells ready for release
Newly generated- made as required

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8
Q

Examples of performed mediators

A

Histamine
Heparin
Granule proteins in eosinophils
Some cytokines
Peptidergic
Neurotransmitters
ATP
protease

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9
Q

Example of newly-generated mediators?

A

Lipid-derived mediators
Cytokines and chemokines
Reactive oxygen and nitrogen species

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10
Q

Prostaglandin D2, leukotriene C4 from mast cells example of what mediators?

A

Newly generated—> Lipid- derived mediators

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11
Q

IL-4,5,3,33, CCL-2, 20 (require gene transcription and protein synthesis) example of what mediators?

A

Newly-generated —> cytokinesand cheekiness

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12
Q

Majority of allergens are?

A

Proteins

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