Pathophysiology Of Allergy Flashcards
Anaphylaxis define.
Severe systemic allergic reaction
Allergic diseases are characterised by inflammation activated by?
IgE
What initiates an allergic disease?
Underlying innate immune mechanisms
Resident vs infiltrating cells difference
Resident= are in particular tissues
Infiltrating = involved in inflammation by recruitment from the circulation
Blood cells can beactivated using signaling molecules which attract the cells to site of inflammation. How?
- Signalling molecules can be chemical attractants
2 . Some are adhesive molecules
How might adhesive molecules attract the cells to site of inflammation?
Blood cells move across the walls of blood vessels and out into tissues where they gain access to other adhesion molecules, trapping infiltrating cells at tissue sites where needed
Mediator plus can be?
Preformed -stored within cells ready for release
Newly generated- made as required
Examples of performed mediators
Histamine
Heparin
Granule proteins in eosinophils
Some cytokines
Peptidergic
Neurotransmitters
ATP
protease
Example of newly-generated mediators?
Lipid-derived mediators
Cytokines and chemokines
Reactive oxygen and nitrogen species
Prostaglandin D2, leukotriene C4 from mast cells example of what mediators?
Newly generated—> Lipid- derived mediators
IL-4,5,3,33, CCL-2, 20 (require gene transcription and protein synthesis) example of what mediators?
Newly-generated —> cytokinesand cheekiness
Majority of allergens are?
Proteins