Cardiac Action Potentials And ECGs Flashcards

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1
Q

What determines direction of flow?

A

Pressure
Valves

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2
Q

Deoxygenated blood pathway to oxygenated blood to body

A

Deoxygenated blood is pumped by the right ventricle into the lungs via the pulmonary arteries to become oxygenated
Then returns to the heart to be pumped around the body but the left ventricle (the wall of the LV is thicker)

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3
Q

Direction of flow through the heart is controlled by. Two factors:

A

Pressure+valves
Pressure increases as the chamber of the heart contract and blood will want to flow from high to low pressure
Pressure is almost mostly responsible for opening and closing of valves which help to direct the flow of blood

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4
Q

Systole vs diastole

A

Systole : contraction
diastole : relaxation

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5
Q

Cardiac cycle and times

A

Atrial systole begins 0-100msec

Atrial systole ends, atrial diastole begins 100-370 msec
Ventricular systole- first phase
Ventricular systole- second phase

Ventricular diastole -early 370-800 msec
Ventricular diastole -late

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6
Q

What happens at atrial systole?

A

Atrial contraction forces small amount of additional blood into relaxed ventricles

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7
Q

What happens at ventricular systole: first and second phase?

A

First phase= ventricular contraction pushes AV valves closed but does not create enough pressure to open semilunar valves
Second phase= as ventricular pressure rises and exceeds pressure in arteries the semilunar valves open and blood ejected

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8
Q

What happens at ventricular diastole - early and late

A

Early- ventricles relax pressure in ventricles drops; blood flows back against cusps of semilunar valves and forces them closed. Blood flows into relaxed atria
Late- all chambers are relaxed. Ventricles fill passively

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9
Q

Isovolumetric contraction

A

Right when atriole diastole begins, ventricular contracting = av valves close but then there is a short period where pressure increases in ventricles as they contract but there is no movement of blood

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10
Q

Is there a positive or negative charge inside cell?

A

More negative charge

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11
Q

Chemical gradient in cells established by?

A

Na/K ATPase
High K inside and low outside
High Na outside and low inside

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12
Q

In resisting state explain Na/K ATPase

A

Relatively impermeable to Na, but there is some movement of K
Facilitated by so called potassium ‘leak’ channels= electrical gradient

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13
Q

Equilibrium potential of an ion is?

A

The membrane potential at which the electrical and chemical forces acting on that ion are in balance and there is no net movement of the ion

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14
Q

Membrane potential of K and Na

A

K= -90 mV
Na= +60 mV

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15
Q

Depolarisation is when?

A

Membrane potential becomes more positive than resting membrane potential

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16
Q

Repolarisation is when?

A

The membrane potential is in a depolarised state and returns back to resting

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17
Q

Why does cardiac action potential have a longer duration than typical neuronal action potential?

A

This is because of the plateau phase due to Ca2+ entry

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18
Q

Phases in cardiac AP+ how long does it last roughly?

A

Phases 1-4
200 ms

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19
Q

Cardiac action potential: phase 0

A

Depolarisation caused by opening of Na channels

20
Q

Cardiac action potential: phase 1

A

Transient repolarisation
At this phase Na channels inactivate
K channels open and membrane starts to repolarise (as the positively charged K leave the cell)

21
Q

Cardiac action potential: phase 2

A

Plateau phase where Ca 2+ channels open Ca enters the cell
K+ still open
No net movement of charge as flow of these two ion’s balance out (both +tive)

22
Q

Cardiac action potential: phase 3

A

Ca channels close and K+ are open
Membrane repolarisation as the k+ ions leave the cell

23
Q

Calcium influx =

A

Contraction
Calcium binds to troponin

24
Q

When Ca2+ enters the cell during cardiac AP what happens? Effect -linked to contraction

A

Binds to troponin which is attached to tropomyosin which causes conformational change in tropomyosin and exposes myosin binding site on the actin fibre
Allowing it to interact with actin and we get cross bridge formation = initiates contraction

25
Q

Action potentials are what type of signals?

A

Electrical

26
Q

Action potentials initiate where? And pathway

A

In SA node and spread around the heart in the cardiac conduction system
Electrical signal reaches cardiomyocytes in atrial and ventricles= spread to those contractile cells = no AP in these cells

27
Q

Muscle cells /cardiomyocytes are functionally coupled to other muscle cells by? Benefit?

A

Intercalated discs with gap junctions= allow spread of electrical activity to pass from cell to cell
When reached individual cell = initiates AP with associated Ca2+ influx so contraction

28
Q

The AP looks different (regional changes) in the heart why?

A

Due to regional differences in ion channels in different parts of the heart

29
Q

Initiating region of electrical impulse

A

SINOATRIAL NODE SAN

30
Q

Delay node to enable ventricular filling?

A

Atrioventricular (AV) node

31
Q

Bundle branches define:

A

Electrical conductance pathways through left and right myocardium, include bundle of HIs

32
Q

Purkinje fibres:

A

Specialised cardiac myocardium-like cells that are responsible for translating electrical impulse into contractile force

33
Q

Resting membrane potential depolarised at around?

A

-60mV

34
Q

SA node fires about ? How many times?

A

80-100 times per minute to initiate the heart beat

35
Q

Threshold potential around?

A

Between -50 and -55 mV

36
Q

Impulse conduction through the heart steps:

A
  1. Electrical activity initiates in the SA node
  2. Spreads out through the right atria to AV node and also across to left atria (note= spread of depolarisation and AP firing in atrial cardiomyocytes)
  3. When it reaches AV node 100msec delay. Atria contract
  4. Impulse travels along interventricular septum down the bundle branches and into purkinje fibres
  5. Distributed by purkinje fibres and relayed throughout ventricular myocardium. Atria contraction completed. Ventricular contraction begins =225m sec
37
Q

When electrical activity reaches AV node there is 100msec delay why?

A

Allows the atria to contract before the ventricles

38
Q

ECG measure?

A

The electrical activity in the heart
Records atrial and ventricular depolarisations and repolarisations

39
Q

Atrial depolarisation on ECG?

A

P wave
Spread of electrical activity in atria

40
Q

Ventricle depolarisation in ECG?

A

QRS complex
Spread of electrical activity into the ventricles

41
Q

Ventricular repolarisation in ECG?

A

T wave
Return of resting membrane potential in the ventricles

42
Q

We can study ECGs to detect?

A

Abnormalities in the electrical conduction system
Cardiologists analyse specific intervals and segments to study and diagnose specific abnormalities in cardiac function

43
Q

The p WAVE initiates before?

A

Atrial systole

44
Q

QRS complex initiates before?

A

Ventricular systole

45
Q

T wave occurs ?

A

At the end of ventricular systole before ventricular diastole
=spread of repolarisation which represents recovery phase of the cardiac AP to allow myocytes to relax

46
Q

When do AV valves open? And close?

A

When atrial pressure is higher than ventricular pressures + close when pressure gradient reversed

47
Q

When do semilunar valves open and close?

A

Open when ventricular pressure is higher than aortic/pulmonary pressure and close when pressure gradient reversed