Cardiac Action Potentials And ECGs Flashcards
What determines direction of flow?
Pressure
Valves
Deoxygenated blood pathway to oxygenated blood to body
Deoxygenated blood is pumped by the right ventricle into the lungs via the pulmonary arteries to become oxygenated
Then returns to the heart to be pumped around the body but the left ventricle (the wall of the LV is thicker)
Direction of flow through the heart is controlled by. Two factors:
Pressure+valves
Pressure increases as the chamber of the heart contract and blood will want to flow from high to low pressure
Pressure is almost mostly responsible for opening and closing of valves which help to direct the flow of blood
Systole vs diastole
Systole : contraction
diastole : relaxation
Cardiac cycle and times
Atrial systole begins 0-100msec
Atrial systole ends, atrial diastole begins 100-370 msec
Ventricular systole- first phase
Ventricular systole- second phase
Ventricular diastole -early 370-800 msec
Ventricular diastole -late
What happens at atrial systole?
Atrial contraction forces small amount of additional blood into relaxed ventricles
What happens at ventricular systole: first and second phase?
First phase= ventricular contraction pushes AV valves closed but does not create enough pressure to open semilunar valves
Second phase= as ventricular pressure rises and exceeds pressure in arteries the semilunar valves open and blood ejected
What happens at ventricular diastole - early and late
Early- ventricles relax pressure in ventricles drops; blood flows back against cusps of semilunar valves and forces them closed. Blood flows into relaxed atria
Late- all chambers are relaxed. Ventricles fill passively
Isovolumetric contraction
Right when atriole diastole begins, ventricular contracting = av valves close but then there is a short period where pressure increases in ventricles as they contract but there is no movement of blood
Is there a positive or negative charge inside cell?
More negative charge
Chemical gradient in cells established by?
Na/K ATPase
High K inside and low outside
High Na outside and low inside
In resisting state explain Na/K ATPase
Relatively impermeable to Na, but there is some movement of K
Facilitated by so called potassium ‘leak’ channels= electrical gradient
Equilibrium potential of an ion is?
The membrane potential at which the electrical and chemical forces acting on that ion are in balance and there is no net movement of the ion
Membrane potential of K and Na
K= -90 mV
Na= +60 mV
Depolarisation is when?
Membrane potential becomes more positive than resting membrane potential
Repolarisation is when?
The membrane potential is in a depolarised state and returns back to resting
Why does cardiac action potential have a longer duration than typical neuronal action potential?
This is because of the plateau phase due to Ca2+ entry
Phases in cardiac AP+ how long does it last roughly?
Phases 1-4
200 ms