Renal - IgA vasculitis Flashcards
What is Henoch-schonlein purpura?
IgA-mediated small vessel vasculitis
seen in children 3-5 after a infection!
What causes inflammation in HSP?
IgA deposits in blood vessels.
What are the main organs affected in HSP?
Skin, kidneys, and GI tract.
What typically triggers HSP?
Upper airway infection or gastroenteritis.
What are the key clinical features of HSP?
(1) Palpable purpuric rash on legs, arms, buttocks, ankles (100%).
(2) Joint pain (60-80%).
(3) Abdominal pain (60%).
(4) Renal involvement (50%) → IgA nephritis, haematuria, proteinuria, oedema.
+ scrotal involvement e.g. swelling
What key feature differentiates HSP from ITP?
HSP has proteinuria; ITP does not.
What conditions should be excluded when diagnosing HSP?
Meningococcal septicaemia, leukaemia, ITP, HUS.
How is renal involvement monitored in HSP?
Blood pressure and urinalysis for 6-12 months.
What should be done if urinalysis is abnormal?
Spot urine sample to quantify proteinuria (ACR or PCR).
How long does HSP usually last?
Most cases resolve spontaneously within 4 weeks.
What is the mainstay of treatment for HSP?
Supportive care → analgesia, rest, and proper hydration.
What is the prognosis of HSP?
Usually self-limiting, but 1/3 of patients have recurrence within 6 months.
