Renal Hemodynamics- Weber Flashcards
kidney functions to ______ metabolic waste products, foreign chemicals, drugs, and hormone metabolites
excrete
kidneys______ water and electrolyte balance (by increasing excretion or reabsorption)
regulate
what happens if Na+ intake increases
kidney compensates by excreting what we have in excess
the kidneys regulate arterial pressure by stimulating what system
RAAS
kidneys regulate what balance by excreting HCO3- if pH goes above 7.4
acid-base balance
what 3 things does the kidney help synthesize
erythrocytes
vitamin D (active form)
glucose
most important function of kidneys
filtering the plasma
what is so important about filtering the plasma
get the waste products out of blood
kidney filters the plasma and then does what
puts the filtered plasma back into blood
severe abnormalities of body fluid volumes and composition occur in this patient
patient with chronic kidney disease or acute kidney failure
if you see patient with abnormal ion concentrations and body fluid volumes what are you thinking
kidney disease
_____% of what is filtered in bowman’s capsule gets picked up by what
60-70%; peritubular capillaries
nephrons are coupled w/ what
renal vasculature
3 main kidney processes
glomerular filtration
tubular reabsorption
tubular secretion
net effect of 3 main kidney processes
excretion
what do we see in urine
what was removed from the blood
site where tubular reabsorption mainly happens
PCT
site where tubular secretion mainly happens
DCT and collecting duct
baroreceptors of the kidney
JG cells
what part of renal corpuscle allows us to maintain high pressure and create ultrafiltrate
fenestrated endothelium of capillaries
sense solute delivery (what gets moved into glomerular capillaries)
macula densa
___% of plasma that enters glomerulus is filtered
20%
____% of plasma that enters glomerulus is not filtered and leaves through efferent arteriole
80%
general cardiac output of body in liters
5L
___% of perfusion of whole system goes to the kidneys
20%
normal GFR
125 ml/min
why is the control of GFR so important?
b/c our entire plasma volume is filtered 60X per day
what 2 things influence how things are filtered:
- particle size
- charge
smaller particles like water, Na+, and glucose are freely or not freely filtered
freely filtered (1.0)
one of the key components of generating oncotic pressure
albumin (protein)
not freely filtered (good b/c want to keep this in vascular space)
albumin
presence of protein in urine sample means what
something is wrong