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URN Biweekly 1 > Glomerulonephritis in Systemic Disease > Flashcards

Glomerulonephritis in Systemic Disease Flashcards

1
Q

top to bottom

A

top: macula densa
PCT
brush border (of PCT)
glomerulus
DCT
basement membrane

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2
Q

leading cause of end stage renal disease (ESRD) in the US

A

diabetic nephropathy

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3
Q

risk of this is greater in african americans and native americans w/ T2DM

A

diabetic nephropathy

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4
Q

2 main lesions of diabetic nephropathy

A
  1. glomerular lesions
  2. renal vascular lesions
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5
Q

main type of glomerular lesion seen in DN

A

nodular glomerulosclerosis

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6
Q

what specific nodules seen in glomerulosclerosis in patient with diabetes nephropathy

A

Kimmelstiel-Wilson nodules

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7
Q
A

Kimmelsteil-Wilson nodules (DN)

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8
Q
A

nodular sclerosis of DN

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9
Q

main renal vascular lesion seen in diabetic nephropathy

A

renal arteriosclerosis (afferent and efferent)

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10
Q

what is seen under light microscopy in diabetic nephropathy

A

nodular glomerulosclerosis and diffuse mesangial sclerosis

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11
Q

what is seen under immunofluorescence for diabetic nephropathy

A

IgG linear staining

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12
Q

what is seen under electron microscopy for diabetic nephropathy

A

diffuse thickening of GBM and increased mesangial matrix!!!

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13
Q

anti-IgG stain

A

diabetic nephropathy

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14
Q

nodular diabetic glomerulosclerosis; what is seen

A

increased mesangial matrix and GBM thickening

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15
Q
A

insudative lesions also seen in DN

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16
Q

this nephritis shows kidney abnormalities in IF and EM stains

A

lupus nephritis

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17
Q

gold standard to diagnose renal disease

A

renal biopsy

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18
Q

3 things to look for in renal biopsy of patient with lupus nephritis

A
  1. wire loops (crescents)
  2. full house on IF
  3. tubuloreticular inclusions
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19
Q

class I and II lupus nephritis deals with what

A

mesangium

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20
Q

IF and EM of class I and II lupus nephritis shows what

A

mesangial immune complex deposition

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21
Q

main takeaway of lupus nephritis class III

A

lesions in <50% of glomeruli (focal lupus nephritis)

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22
Q

lupus nephritis class

A

class III

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23
Q

main takeaway of lupus nephritis class IV

A

> /= 50% glomeruli affected (diffuse lupus nephritis)

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24
Q

in class IV lupus nephritis, what is seen on LM

A

wire loops

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25
in class IV lupus nephritis, what is seen on IF
full house
26
in class IV lupus nephritis, what is seen on EM
tubuloreticular inclusions
27
wire loops seen, what class of lupus nephritis
class IV
28
wire loops seen, what class of lupus nephritis
class IV
29
"full house"; what class of lupus nephritis
class IV
30
lupus nephritis class V aka
membranous lupus nephritis
31
what is seen on IF and EM stain for patient with class V lupus nephritis
subepithelial immune deposits
32
subepithelial deposits seen; what class of lupus
class V
33
subepithelial deposits, what class of lupus nephritis
class V
34
tubuloreticular inclusions seen; what class of lupus nephritis
class IV
35
nonselective proteinuria; deposits of beta pleated sheets
Amyloidosis
36
most common type of amyloidosis and poorest prognosis
AA amyloidosis
37
+ congo red stain; apple-green birefringence under polarized light
Amyloidosis
38
congo red stain
Amyloidosis
39
Amyloidosis
40
Amyloidosis
41
autoimmune disease w/ linear IgG and accounts for 15% of crescent glomerulonephritis
anti-glomerular BM disease
42
pulmonary and renal syndrome induced by cross rxn of anti-GBM Ab's w/ pulm BM
Goodpasture syndrome
43
abrupt onset w/ severe oliguria or anuria
anti-glomerular BM disease
44
linear IgG
anti-GBM disease
45
crescents
anti-GBM disease
46
small vessel vasculitis; p-ANCA
microscopic polyangiitis
47
lungs and kidneys affected; presents w/ hematuria, proteinuria, joint pain and palpable purpura
microscopic polyangiitis
48
microscopic polyangiitis
49
triad: necrotizing granulomatous inflammation in URT necrotizing vasculitis of small-medium vessels in lungs focal necrotizing glomerulonephritis
Granulomatosis w/ polyangiitis
50
granulomas
granulomatosis w/ polyangiitis
51
palpable purpura (rash) migratory arthralgias abd pain renal disease CHILDREN
Henoch-Schonlein purpura
52
inflammatory rxn caused by deposition of IgA-containing immune complexes
Henoch-Schonlein Purpura
53
mainly affects children and can lead to nephrotic syndrome
Henoch-Schonlein purpura
54
IF: shows IgA deposits in mesangium
Henoch-Schonlein purpura
55
mesangial expansion due to IgA deposition
Henoch-Schonlein purpura
56
inflammatory rxn
Henoch-Schonlein purpura
57
Henoch-Schonlein purpura
58
progressive nephritis associated w/ deafness and ocular abnormalities
Alport Syndrome
59
EM shows what for Alport Syndrome
thinning and thickening of GBM
60
thin GBM and macrophages
Alport Syndrome
61
thin GBM and fibrosis
Alport Syndrome
62
alpha 5 subtype stained (discontinuous---so abnormal)
Alport Syndrome
63
thin and thick GBM
Alport Syndrome
64
uniform GBM thinning; NO deterioration of renal fx; mild proteinuria
thin basement membrane nephropathy
65
LM: normal EM: thinning of lamina densa of GBM
thin basement membrane nephropathy
66
thin basement membrane nephropathy
67
x-linked; accumulation of Gb3 in lysosomes
Fabry disease
68
cause: deficiency of alpha-galactosidase A in lysosomes
Fabry disease
69
children; renal involvement; angiokeratomas
Fabry Disease
70
EM: massive accumulation of laminated inclusion bodies
Fabry Disease
71
massive accumulation of inclusion bodies
Fabry Disease
72
laminated inclusion bodies
Fabry disease

URN Biweekly 1 (21 decks)

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