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URN Biweekly 1 > Glomerulonephritis in Systemic Disease > Flashcards

Glomerulonephritis in Systemic Disease Flashcards

1
Q

top to bottom

A

top: macula densa
PCT
brush border (of PCT)
glomerulus
DCT
basement membrane

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2
Q

leading cause of end stage renal disease (ESRD) in the US

A

diabetic nephropathy

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3
Q

risk of this is greater in african americans and native americans w/ T2DM

A

diabetic nephropathy

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4
Q

2 main lesions of diabetic nephropathy

A
  1. glomerular lesions
  2. renal vascular lesions
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5
Q

main type of glomerular lesion seen in DN

A

nodular glomerulosclerosis

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6
Q

what specific nodules seen in glomerulosclerosis in patient with diabetes nephropathy

A

Kimmelstiel-Wilson nodules

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7
Q
A

Kimmelsteil-Wilson nodules (DN)

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8
Q
A

nodular sclerosis of DN

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9
Q

main renal vascular lesion seen in diabetic nephropathy

A

renal arteriosclerosis (afferent and efferent)

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10
Q

what is seen under light microscopy in diabetic nephropathy

A

nodular glomerulosclerosis and diffuse mesangial sclerosis

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11
Q

what is seen under immunofluorescence for diabetic nephropathy

A

IgG linear staining

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12
Q

what is seen under electron microscopy for diabetic nephropathy

A

diffuse thickening of GBM and increased mesangial matrix!!!

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13
Q

anti-IgG stain

A

diabetic nephropathy

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14
Q

nodular diabetic glomerulosclerosis; what is seen

A

increased mesangial matrix and GBM thickening

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15
Q
A

insudative lesions also seen in DN

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16
Q

this nephritis shows kidney abnormalities in IF and EM stains

A

lupus nephritis

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17
Q

gold standard to diagnose renal disease

A

renal biopsy

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18
Q

3 things to look for in renal biopsy of patient with lupus nephritis

A
  1. wire loops (crescents)
  2. full house on IF
  3. tubuloreticular inclusions
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19
Q

class I and II lupus nephritis deals with what

A

mesangium

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20
Q

IF and EM of class I and II lupus nephritis shows what

A

mesangial immune complex deposition

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21
Q

main takeaway of lupus nephritis class III

A

lesions in <50% of glomeruli (focal lupus nephritis)

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22
Q

lupus nephritis class

A

class III

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23
Q

main takeaway of lupus nephritis class IV

A

> /= 50% glomeruli affected (diffuse lupus nephritis)

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24
Q

in class IV lupus nephritis, what is seen on LM

A

wire loops

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25
Q

in class IV lupus nephritis, what is seen on IF

A

full house

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26
Q

in class IV lupus nephritis, what is seen on EM

A

tubuloreticular inclusions

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27
Q

wire loops seen, what class of lupus nephritis

A

class IV

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28
Q

wire loops seen, what class of lupus nephritis

A

class IV

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29
Q

“full house”; what class of lupus nephritis

A

class IV

30
Q

lupus nephritis class V aka

A

membranous lupus nephritis

31
Q

what is seen on IF and EM stain for patient with class V lupus nephritis

A

subepithelial immune deposits

32
Q

subepithelial deposits seen; what class of lupus

A

class V

33
Q

subepithelial deposits, what class of lupus nephritis

A

class V

34
Q

tubuloreticular inclusions seen; what class of lupus nephritis

A

class IV

35
Q

nonselective proteinuria; deposits of beta pleated sheets

A

Amyloidosis

36
Q

most common type of amyloidosis and poorest prognosis

A

AA amyloidosis

37
Q

+ congo red stain; apple-green birefringence under polarized light

A

Amyloidosis

38
Q

congo red stain

A

Amyloidosis

39
Q
A

Amyloidosis

40
Q
A

Amyloidosis

41
Q

autoimmune disease w/ linear IgG and accounts for 15% of crescent glomerulonephritis

A

anti-glomerular BM disease

42
Q

pulmonary and renal syndrome induced by cross rxn of anti-GBM Ab’s w/ pulm BM

A

Goodpasture syndrome

43
Q

abrupt onset w/ severe oliguria or anuria

A

anti-glomerular BM disease

44
Q

linear IgG

A

anti-GBM disease

45
Q

crescents

A

anti-GBM disease

46
Q

small vessel vasculitis; p-ANCA

A

microscopic polyangiitis

47
Q

lungs and kidneys affected; presents w/ hematuria, proteinuria, joint pain and palpable purpura

A

microscopic polyangiitis

48
Q
A

microscopic polyangiitis

49
Q

triad:
necrotizing granulomatous inflammation in URT
necrotizing vasculitis of small-medium vessels in lungs
focal necrotizing glomerulonephritis

A

Granulomatosis w/ polyangiitis

50
Q

granulomas

A

granulomatosis w/ polyangiitis

51
Q

palpable purpura (rash)
migratory arthralgias
abd pain
renal disease
CHILDREN

A

Henoch-Schonlein purpura

52
Q

inflammatory rxn caused by deposition of IgA-containing immune complexes

A

Henoch-Schonlein Purpura

53
Q

mainly affects children and can lead to nephrotic syndrome

A

Henoch-Schonlein purpura

54
Q

IF: shows IgA deposits in mesangium

A

Henoch-Schonlein purpura

55
Q

mesangial expansion due to IgA deposition

A

Henoch-Schonlein purpura

56
Q

inflammatory rxn

A

Henoch-Schonlein purpura

57
Q
A

Henoch-Schonlein purpura

58
Q

progressive nephritis associated w/ deafness and ocular abnormalities

A

Alport Syndrome

59
Q

EM shows what for Alport Syndrome

A

thinning and thickening of GBM

60
Q

thin GBM and macrophages

A

Alport Syndrome

61
Q

thin GBM and fibrosis

A

Alport Syndrome

62
Q

alpha 5 subtype stained (discontinuous—so abnormal)

A

Alport Syndrome

63
Q

thin and thick GBM

A

Alport Syndrome

64
Q

uniform GBM thinning; NO deterioration of renal fx; mild proteinuria

A

thin basement membrane nephropathy

65
Q

LM: normal
EM: thinning of lamina densa of GBM

A

thin basement membrane nephropathy

66
Q
A

thin basement membrane nephropathy

67
Q

x-linked; accumulation of Gb3 in lysosomes

A

Fabry disease

68
Q

cause: deficiency of alpha-galactosidase A in lysosomes

A

Fabry disease

69
Q

children; renal involvement; angiokeratomas

A

Fabry Disease

70
Q

EM: massive accumulation of laminated inclusion bodies

A

Fabry Disease

71
Q

massive accumulation of inclusion bodies

A

Fabry Disease

72
Q

laminated inclusion bodies

A

Fabry disease

URN Biweekly 1 (21 decks)

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