Receptor Tyrosine Kinase Flashcards
1
Q
What are growth factors
E.G.- EGF, NGF, FGF
A
Ligands and primary messengers in epidermal, nerve, and and fibroblasts
2
Q
What do ligands do to RTKs
A
They bring two RTKs together to form a dimer
3
Q
What is the intercellular portion of RTKs
A
Tyrosine kinases
4
Q
When two RTKs are brought together, what happens?
A
They form a dimer and they phosphorylate each other
5
Q
What kinds of domains does Grb2 have?
A
SH2 and SH3 domains
6
Q
What do SH3 domains bind?
A
Poly-proline sequences of SOS
7
Q
What is SOS
A
A GEF for the GTP protein Ras
8
Q
What are scaffolding/adapter proteins
A
They are proteins that bring or hold other proteins together (like grb2)
9
Q
What does it mean to “recruit”
A
To bring a protein to a particular place
