Lecture 21 Extracellular Matrix (ECM)

Question 1

What are cell walls made up of?

Answer 1

peptidyl lycan

gram positive- thick cell wall

gram negative- thin cell wall between two membranes

Question 2

What is Chitin (you gotta be chitin me)

Answer 2

Located in cells walls of fungi

Question 3

Three types of proteins that make up animal ECM

Answer 3

collagen and elastin
proteoglycan
multi-adhesive matrix proteins

Question 4

What cells make the ECM

Answer 4

all cells but mostly fibroblasts because they are a one trick pony… yea thats why… science says so

Question 5

collagen vs elastin

Answer 5

collagen is the most abudant protein in humans and is also rigid

elastin is stretchy like play-doh (yes im tired give me a break)

Question 6

Characteristics of proteoglycans (AKA the sluts of the protein world)

Answer 6

Proteoglycans can be stretched… sluts
or attached to the cell surface

They have more carbohydrates than proteins (fat sluts)

Proteoglycans are negatively charged (negative nancy’s) and bind a lot of water which causes them to be slippery (sluts)

They also resist contraction (because they do what they want)

Question 7

What is an example of a proteoglycan

Answer 7

cartilage

Question 8

What is fibronectin

Answer 8

it has RGD motif, which can bind integrins

found in most other ECM’s

Question 9

What is a motif (i dont know but it sounds like a fancy drink)

Answer 9

a specific short sequence of amino acids with a specific function