Cytokine Signaling Flashcards
1
Q
What are cytokines
A
Primary messengers that regulate cell differentiation
2
Q
What are cytokines receptors
A
Extracellular part bind cytokines
Intracellular part bonds JAKs
3
Q
What are JAKs
A
Tyrosine kinases that phosphorylate tyrosines
4
Q
What are JAKs activated by?
A
A cytokine receptor
5
Q
What do JAKs phosphrylate
A
Cytokine receptors and later STATS
6
Q
What are STATs
A
Transcription factors with SH2 domains
Bind cytokine receptors
7
Q
What is the SH2 domain?
A
They are on lots of proteins and bind different phosphotyrosines
8
Q
What are STATs activated by
A
Phosphorylated JAKs
