Lecture 25-TGF Receptors Flashcards
1
Q
What do TGF receptors do?
A
Regulate cell growth
2
Q
What does TGF stand for?
A
Transforming growth factor
3
Q
TGF receptor: What is part binds to TGF
A
Extracellular
4
Q
TGF receptor: what is the intercellular part?
A
A kinase that phosphorylates smad’s
5
Q
What are smad’s
A
Transcription factors
6
Q
When smad’s are phosphorylated, what happens to them?
A
They change shape and a nls sequence becomes exposed. They then go to the nucleus and trigger cell growth.
