Rapid Review - Classic Labs / Findings (2)

Question 1

Desquamated epithelium casts in sputum

Answer 1

Curschmann spirals (bronchial asthma; can result in whorled mucous plugs)

Question 2

Disarrayed granulosa cells in eosinophilic fluid

Answer 2

Call-Exner bodies (granulosa-theca cell tumor of the ovary)

Question 3

Dysplastic squamous cervical cells with nuclear enlargement and hyperchromasia

Answer 3

Koilocytes (HPV: predisposes to cervical cancer)

Question 4

Enlarged cells with intranuclear inclusion bodies

Answer 4

“Owl eye” appearance of CMV

Question 5

Enlarged thyroid cells with ground-glass nuclei

Answer 5

“Orphan Annie” eyes nuclei (papillary carcinoma of the thyroid)

Question 6

Eosinophilic cytoplasmic inclusion in liver cell

Answer 6

Mallory body (alcoholic liver disease)

Question 7

Eosinophilic cytoplasmic inclusion in nerve cell

Answer 7

Lewy body (Parkinson disease)

Question 8

Eosinophilic globule in liver

Answer 8

Councilman body (toxic or viral hepatitis, often yellow fever)

Question 9

Eosinophilic inclusion bodies in cytoplasm of hippocampal and cerebellar nerve cells

Answer 9

Negri bodies of rabies

Question 10

Extracellular amyloid deposition in gray matter of brain

Answer 10

Senile plaques (Alzheimer disease)

Question 11

Giant B cells with bilobed nuclei with prominent inclusions (“owl’s eye”)

Answer 11

Reed-Sternberg cells (Hodgkin lymphoma)

Question 12

Glomerulus-like structure surrounding vessel in germ cells

Answer 12

Schiller-Duval bodies (yolk sac tumor)

Question 13

“Hair on end” (crew-cut) appearance on x-ray

Answer 13

β-thalassemia, sickle cell anemia (marrow expansion)

Question 14

hCG elevated

Answer 14

Choriocarcinoma, hydatidiform mole (occurs with and without embryo, and multiple pregnancy)

Question 15

Heart nodules (granulomatous)

Answer 15

Aschoff bodies (rheumatic fever)

Question 16

Heterophile antibodies

Answer 16

Infectious mononucleosis (EBV)

Question 17

Hexagonal, double-pointed, needle-like crystals in bronchial secretions

Answer 17

Bronchial asthma (Charcot-Leyden crystals: eosinophilic granules)

Question 18

High level of d-dimers

Answer 18

DVT, PE, DIC

Question 19

Hilar lymphadenopathy, peripheral granulomatous lesion in middle or lower lung lobes (can calcify)

Answer 19

Ghon complex (1° TB: Mycobacterium bacilli)

Question 20

“Honeycomb lung” on x-ray or CT

Answer 20

Interstitial pulmonary fibrosis

Question 21

Hypercoagulability (leading to migrating DVTs and vasculitis)

Answer 21

Trousseau syndrome (adenocarcinoma of pancreas or lung)

Question 22

Hypersegmented neutrophils

Answer 22

Megaloblastic anemia (B12 deficiency: neurologic symptoms; folate deficiency: no neurologic symptoms)

Question 23

Hypertension, hypokalemia, metabolic alkalosis

Answer 23

Conn syndrome

Question 24

Hypochromic, microcytic anemia

Answer 24

Iron deficiency anemia, lead poisoning, thalassemia (fetal hemoglobin sometimes present)

Question 25

Increased AFP in amniotic fluid/maternal serum

Answer 25

Dating error, anencephaly, spina bifida (neural tube defects)

Question 26

Increased uric acid levels

Answer 26

Gout, Lesch-Nyhan syndrome, tumor lysis syndrome, loop and thiazide diuretics

Question 27

Intranuclear eosinophilic droplet-like bodies

Answer 27

Cowdry type A bodies (HSV or CMV)

Question 28

Iron-containing nodules in alveolar septum

Answer 28

Ferruginous bodies (asbestosis: increased chance of mesothelioma)

Question 29

Keratin pearls on a skin biopsy

Answer 29

Squamous cell carcinoma

Question 30

Large lysosomal vesicles in phagocytes, immunodeficiency

Answer 30

Chédiak-Higashi disease (congenital failure of phagolysosome formation)