PSL301: Cardio 8 Flashcards
Pc
capillary hydrostatic pressure
Pif
interstitial fluid pressure
(pi)c
plasma colloid osmotic pressure
(pi)if
Interstitial fluid colloid pressure
Define: Pc
move fluid out
due to fluid pressure in blood
Define: Pif
move fluid in
Opposes outward movement of Pc
due to fluid pressure in ISF
Define: (pi)c
Move fluid in
if proteins in blood > proteins in ISF
Define: (pi)if
Move fluid out
if proteins in ISF > proteins in blood
Formula: net fluid pressure (at capillaries)
Fluid out - fluid in
[Pc + (pi)if] - [Pif + (pi)c]
Value: Pif
why?
- 3 mmHg
Lymphatic system remove fluid
Value: Pc
45 to 10 mmHg
Value: (pi)if
why?
8 mmHg
Lympathic system remove proteins
Value: (pi)c
28 mmHg
Value: plasma protein concentration
7.3 mg/dl
What makes up the plasma proteins?
75% albumin
25% globulin
Very little fibrinogen
Value: interstitial protein concentration
3 mg/dl
If net fluid pressure is positive…
More fluid going out of vessel
If net fluid pressure is negative…
More fluid going into vessel
Due to the gradient from Pc, __L of net flow outward per day
3L
Forces that push fluid out of vessels
- Hydrostatic pressure
- Pressure from LACK OF fluid in ISF
- Interstitial colloid osmotic pressure
Forces that push fluid into vessels
- plasma colloid osmotic pressure
Value: mean hydrostatic pressure
17.3 mmHg
Value: filtration coefficient
10 mL/min/mmHg
Formula: filtration rate
filtration coefficient * net filtration pressure
Value: net filtration rate
3 mL/min
that much fluid is deposited in ISF every minute
Functions of lympathic system
- Return fluid & proteins to circulatory system
- Pick up fat from intestines and deliver to circulatory system
- Help trap pathogens
Lymphatic system help prevent…
edema
Lymph is derived from…
ISF
Where does the lymphatic system drain into?
subclavian veins
What determines lymph flow?
- Valves
- External compression (skeletal pump)
- Smooth muscle in lymph vessel
- Pif
What if flow in lymphatic system is blocked?
Edema
3 factors that might cause edema
- Increase hydrostatic pressure
- Decrease in plasma protein
- Increase in interstitial proteins
Where does edema happen?
any vascularized tissue
One specific edema disease is…
Elephantiasis
What causes elephantiasis?
small parasitic roundworms
What is the vector for elephantiasis?
Mosquitos
Define: elephantiasis
abnormal enlargement of any part of the body due to obstruction of the lymphatic channels in the area
Fluid accumulation in the abdomen is called…
Ascites
Ascites
Accumulation of fluid in the abdomen
Another name for abdomin
peritoneal cavity
Disease of ascites
Kwashiorkor: lack of protein in diet
Liver cirrhosis: cannot produce enough albumin
What may cause liver cirrhosis?
Alcoholism
Hepatitis
Fatty liver disease
Acetaminophen
CVD includes…
- CHD
- Cerebrovascular disease
- Peripheral arterial disease
- Rheumatic heart disease
- Congenital heart disease
- Deep vein thrombosis & pulmonary embolism
Rheumatic heart disease is caused by…
Streptococcus pyogenes infection -> Rheumatic fever
