PSL301: Cardio 4 Flashcards

1
Q

First heart sound

A

“lub”

Closing of AV valves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Second heart sound

A

“dup”

Closing of semilunar valves

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Ausculation

A

Listening to heart

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What might cause a leaky aortic valve?

A

Calcification of aortic walls (hardening)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What happens when the valves don’t close properly?

A

Blood leaks backwards

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

When the aortic valve doesn’t fully close, what sound is made?

A

sloshing sound

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Aortic regurgitation

A

Leaking aortic valve (backflow into left ventricle)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Aortic regurgitation seen on PV loop

A
  • Pressure same as normal

- Vol increased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Aortic stenosis

A

Opening of aortic valve is narrower

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Aortic stenosis seen on PV loop

A
  • Volume same as normal

- Pressure increased

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

2 phases of cardiac cycle

A
  1. diastole

2. systole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How does systole pump blood?

A

Contraction raises pressure

Blood flows down pressure gradient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Events on the right & left side of the heart are the ___, but pressure are lower on the ___

A

Same

Right

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ESV =

A

end systolic volume

65 mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

EDV =

A

end diastolic volume

135 mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How much blood we are moving (CO) depends on…

A
  • HR

- Stroke vol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Formula: SV

A

SV = EDV - ESV

Usually 70 mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Inotrope

A

Agent that alters the force or energy of muscular contractions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

How to maximize SV?

A

Higher EDV
Lower ESV
(this maximizes the difference)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Increase preload causes SV to…

Explain

A

Go up

Higher EDV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Define: SV

A

amount of blood pumped by 1 ventricle in 1 contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Formula: CO

A

CO = HR x SV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Define: CO

A

amount of blood pumped per ventricle per unit time

24
Q

Unit for CO

25
Unit for SV
mL/beat
26
What is the normal CO?
5L/min
27
What is normal blood volume?
5L
28
Cardiac reserve is the difference between ___ and ___ CO
Resting | max
29
What does Frank-Starling Law of the Heart ask?
What affects stroke volumes?
30
What affects stroke volume?
- Preload (mostly) | - Afterload
31
Preload
Pressure at the end of diastole
32
Afterload
Pressure during ventricular contraction
33
What increases SV?
``` Increased EDV Exercise (increase venous return) Slow HR (allow more to fill) ```
34
What decreases SV?
Blood loss Rapid HR (no time to fill) Decreased EDV
35
Frank-Starling Law of the Heart states that...
SV increases as EDV increases
36
EDV is affected directly by...
Venous return
37
Venous return is directly affected by
- skeletal muscle pump - Respiratory pump - SNS
38
Force of contraction of heart is affected by...
EDV | Contractility / length of muscle fibre
39
The Starling curve shows..
relationship between stretch (EDV) & force (SV) Increased stretch = increased pressure Increased EDV = increased SV
40
How does increased EDV lead to increased SV?
EDV stretches the sacromere out more
41
What happens to the Starling curve as intensity of exercise increases?
Becomes higher; bigger slope | Same EDV = higher SV
42
What happens when EDV is too high?
Sacromeres stretch too much = left ventricle dysfunction
43
Example of inotrope
NE
44
How does NE affect contractility of the heart?
Starling curve looks like exercise Same EDV = higher SV Increase contractility
45
are NE and E positive or negative inotropes?
Positive (increase contractility)
46
Negative inotropes ___ contractility
decrease
47
Examples of negative inotropes
- B-blocker | - Ca channel blocker
48
What is the purpose of negative inotropes?
- Decrease risk of second MI | - Hypertension
49
Contractility is independent of...
- stretch | - EDV
50
Increase in contractility comes from...
- Sm stimuli - Hormones - more Ca++ - Drugs
51
Define: contractility
increase in contractile strength
52
SNS ___ venous contraction
increases
53
How does Sm NT affect contractility?
Bind to B1 G-proteins -> cAMP & PKA | More Ca++ binding to troponin
54
High blood pressure ___ SV
decreases
55
Only ___ affect the HR
- SNS | - PNS