PSL301: Cardio 6 Flashcards

1
Q

How much blood goes into the heart each pump?

A

0.2 L/min

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2
Q

How much blood goes into the brain each pump?

A

0.7 L/min

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3
Q

Which part of the body does blood flow stay constant?

A

Brain

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4
Q

Where does the most blood get distributed to?

A

Liver

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5
Q

Where do 1/4 of the CO get wired to?

A

Kidneys

Skeletal muscles

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6
Q

What directly affects EDV?

A

Venous return

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7
Q

What affects venous return?

A
  1. Blood volume
  2. Intrathoracic pressure
  3. Venous pressure
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8
Q

At the capillaries, blood always picks the vessel with the lowest…

A

resistance

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9
Q

When one capillary is pinched off, the overall __ is unchanged

A

flow

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10
Q

Pressure in ventricle varies from…

A

10 mmHg to 120 mmHg

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11
Q

Formula: MAP

A

MAP = diastolic P + 1/3(systolic P - diastolic P)

= 2/3(diastolic P) + 1/3(systolic P)

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12
Q

MAP is better known as…

A

Average blood pressure

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13
Q

Arteries store pressure from left ventricle contraction, then uses ___ to send blood to the rest of the body during ventricular diastole

A

elastic recoil

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14
Q

Formula: pulse pressure

A

systolic P - diastolic P

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15
Q

MAP is a function of…

A

CO

Resistance

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16
Q

Define: pulse

A

Pressure wave of circulating blood

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17
Q

Where can pulses be felt?

specific

A
  • temperal artery
  • facial artery
  • carotid arter
  • brachial artery
  • radial artery
  • femoral artery
  • popliteal artery
  • posterior tibial artery
  • dosalis pedis artery
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18
Q

Where can pulses be felt? (general)

A

pressure points

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19
Q

What sounds are heard while measuring blood pressure?

A

Korotkoff sounds

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20
Q

5 Korotkoff sounds

A
  1. Snap: systolic pressure
  2. Murmurs
  3. Taps
  4. Thumping / muting: 10 mmHg above diastolic
  5. Silence: diastolic
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21
Q

Stages of hypertension

A
  1. Normal
  2. Hypertension stage 1
  3. Hypertension stage 2
  4. Hypertensive crisis (emergency!!)
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22
Q

What is normal blood pressure?

A

less than 120

Less than 80

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23
Q

(Pre)-hypertension ____ CVD risk

A

Increases

Positive correlation

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24
Q

MAP is determined by…

A
  1. Blood volume
  2. CO
  3. Resistance
  4. Distribution of blood between arteriole & venous system

(1) and (4) are usually pretty consistant

25
2 responses to increased blood pressure? | which one is slow/fast?
1. Cardio compensation (fast) | 2. Kidney compensation (slow)
26
How does the cardio system compensate for high blood pressure?
- vasodilation | - decreased CO
27
How does the renal system compensate for high blood pressure?
More fluid excreted in urine | Renin-angiotensin system
28
Baroreceptors are located at the...
Major arteries - Aortic arch - Carotid sinus
29
What is the baroreflex?
response to increased / decreased BP | Sensed by baroreceptors
30
At normal state, what is the baroreflex like?
Baroreceptors fire at constant rate
31
When BP is increased, the firing of baroreceptors...
increase
32
Baroreceptors report to...
cardiovascular control center in medulla oblongata
33
alpha-receptor for NE causes... | beta-receptor for NE causes...
vasodilation | vasoconstriction
34
Ultimately, what lowers the BP?
- Decreased peripheral resistance | - Decreased CO
35
Orthostatic hypotension
"head rush" Decrease in BP due to standing up Blood has pooled in the feet, so not enough going to head
36
What secretes renin?
Juxtaglomerular apparatus
37
Purpose of renin
Angiotensinogen -> ANG I
38
What cleaves ANG I -> ANG II
ACE
39
What does ANG II do?
- Vasoconstrict vessels by binding to AT1 receptors in blood vessels - Stimulates production of aldosterone at adrenal cortex by binding to AT1 receptors in adrenal gland
40
Where is aldosterone produced?
adrenal cortex
41
Where is the adrenal cortex located?
on top of the kidney
42
What does aldosterone do?
Tells kidneys to retain salt & water
43
The cleaving of ANG I -> ANG II happens at the...
lungs
44
Renin-angiotensin-aldosterone (RAAS) is only activated...
chronic low blood pressure
45
Where is ACE found?
in the lungs
46
Purpose of RAAS?
Raise blood pressure & volume
47
Where does aldosterone act?
at kidneys
48
Aldosterone is a part of the __ family
steroid
49
How does aldosterone increase salt and water retention at the kidneys?
Increase expression of Na/K pumps & Na channels on collecting duct Pumps Na to ISF -> blood
50
What receptor does ANG II bind to?
AT1
51
Is it possible for angiotensinogen -> ANG II directly?
Yes (alternate pathway)
52
During the reaction with ACE, bradykinin ->
inactive fragments
53
Feedback in the RAAS is from...
- Na intake | - Decreased renin secretion
54
ANF is produced by...when...
Atria in response to high blood pressure
55
ANF
Atrial natriuretic factor
56
What does ANF do?
1. Vasodilation 2. Decrease renin production (Promote water & salt secretion)
57
Abbreviations for atrial natriuretic factor
ANF / ANP / ANH
58
__ antagonizes the effects of ANG II
ANF