Protein Synthesis Inhibitors

Question 1

What drugs bind reversibly to the 30S subunit of the bacterial ribosome preventing binding of tRNA to the mRNA–ribosome complex, thereby inhibiting bacterial protein synthesis?

Answer 1

Tetracycline

Question 2

What does tetracycline commonly treat?

Answer 2

acne and Chlamydia infections

Question 3

What is the most common resistance to tetracycline?

Answer 3

Efflux pump

Question 4

What 2 drugs are NOT hepatically metabolized?

Answer 4

Tetracycline and doxycycline

Question 5

What disease may Tetracycline worsen?

Answer 5

Myasthenia gravis

Question 6

What key adverse effect does tetracycline administration have?

Answer 6

hypoplasia of teeth and a temporary stunting of growth

Question 7

T/F: TCN should NOT be administered along with dietary supplements or antacids

Answer 7

True

Question 8

How are aminoglycosides unique?

Answer 8

Bacterialcidal

Question 9

What are aminoglycosides combined with to produce a synergistic effect?

Answer 9

β-lactam

Question 10

How are aminoglycosides given?

Answer 10

Parenterally

Question 11

How are aminoglycosides dosed?

Answer 11

by lean body mass

Question 12

What can be an adverse effect of aminoglycosides?

Answer 12

Ototoxicity (vertigo)

Nephrotoxicity

Question 13

What is an example of an aminoglycoside?

Answer 13

Gentamicin

Question 14

What macrolide is the first drug of choice as an alternative to penicillin in individuals with an allergy to β-lactam antibiotics?

Answer 14

Erythromycin

Question 15

What is the first “ketolide” antimicrobial agent?

Answer 15

Telithromycin

Question 16

What syndrome is an adverse effect of Macrolides?

Answer 16

Gray baby syndrome

Question 17

What is used as the treatment of infections caused by gram-positive organisms, including MRSA and streptococcus, and anaerobic bacteria?

Answer 17

Clindamycin