Drugs 2 Flashcards
What kind of drugs lower BP by reducing peripheral vascular resistance without reflexively increasing cardiac output; decrease angiotensin II and increase bradykinin levels?
ACE Inhibitors
What kind of drugs lower blood pressure and decrease salt and water retention?
Angiotensin receptor blockers (ARBs)
Which are first-line agents for the treatment of hypertension?
ARBs
What drug is a selective renin inhibitor that treats hypertension?
Aliskiren
What is the recommended treatment option in hypertensive patients with diabetes or angina?
Calcium Channel Blockers
What calcium channel blocker is a Diphenylalkylamine and is the LEAST selective of any calcium channel blocker and has significant effects on both cardiac and vascular smooth muscle cells?
Verapamil
What calcium channel blocker is a Benzothiazepine and affects both cardiac and vascular smooth muscle cells, but it has a less pronounced negative inotropic effect on the heart compared to that of verapamil?
Diltiazem
What class of drugs have a GREATER AFFINITY for vascular calcium channels than for calcium channels in the heart and show little interaction with other cardiovascular drugs, such as digoxin or warfarin, which are often used concomitantly with calcium channel blockers?
Dihydropyridines
T/F: Calcium channel blockers do not dilate veins
True
What causes a REDUCTION IN MYOCARDIAL OXYGEN DEMAND, followed by relief of symptoms and are effective in stable, unstable, and variant angina?
Nitrates
What is the most common adverse effect of nitrates?
Headache
What are competitive inhibitors of HMG CoA reductase, ?
Statins
What are the most potent statins?
Pitavastatin
Rosuvastatin
Atorvastatin
What is the most effective agent for increasing HDL-C and inhibits lipolysis in adipose tissue, thereby reducing production of free fatty acids?
Niacin
What is the only ACE inhibitor that is not eliminated primarily by the kidneys?
Fosinopril
