Bone Disorder drugs

Question 1

What drugs are the preferred agents for prevention and treatment of postmenopausal osteoporosis and bone disorders such as Paget disease, bone metastases, and hypercalcemia in malignancy?

Answer 1

Bisphosphonates

Question 2

What do Bisphosphonates decrease?

Answer 2

bone resorption

Question 3

What do Bisphosphonates increase?

Answer 3

apoptosis

Question 4

What are 2 adverse effects of Alendronate?

Answer 4

esophagitis

osteonecrosis of the jaw

Question 5

What is the only bisphosphonate that causes osteomalacia?

Answer 5

Etidronate

Question 6

What drug is a selective estrogen receptor modulator approved for the prevention and treatment of osteoporosis (increases bone density w/out increasing risk of cancer)?

Answer 6

Raloxifene

Question 7

What drug is used for the treatment of osteoporosis in women who are at least 5 years postmenopausal (but less effective than bisphosphonates), and relief of pain associated with osteoporotic fracture?

Answer 7

Calcitonin

Question 8

What drug is used for treatment of postmenopausal osteoporosis in women at high risk of fracture?

Answer 8

Denosumab

Question 9

What drug was the first approved treatment for osteoporosis that stimulates bone formation?

Answer 9

Teriparatide