Antivirals

Question 1

What cleaves linkages between sialic acid and Hemagglutinin (HA) from both itself and the infected cell surface?

Answer 1

Neuraminidase

Question 2

What antiviral is limited to influenza A infections and is NOT effective against influenza B viruses?

Answer 2

Amantadine

Question 3

What protein does amantadine interfere with?

Answer 3

M2 protein

Question 4

What is the most common adverse drug reaction with Amantadine?

Answer 4

CNS effects

Question 5

What does injection of Peginterferon-α-2a once weekly treat?

Answer 5

Chronic Hepatitis B

Question 6

What does Interferon-α-2b treat?

Answer 6

Hepatitis B and C

Question 7

What drug is the prototypic antiherpetic therapeutic agent and is the treatment of choice for HSV encephalitis (Genital herpes)?

Answer 7

Acyclovir

Question 8

What drug is a prodrug and is metabolized to the active penciclovir?

Answer 8

Famciclovir

Question 9

What is responsible for the beneficial effects of Famciclovir?

Answer 9

Penciclovir

Question 10

What drug is used for HIV infections is converted intracellularly to an active triphosphate compound that inhibits reverse transcriptase thereby inhibiting viral replication?

Answer 10

Zidovudine

Question 11

What protease inhibitor drug is an inhibitor of the HIV protease and bound to plasma proteins?

Answer 11

Ritonavir