Anti-inflammatory Drugs

Question 1

What are all examples of drug classes that put the breaks on inflammatory processes?

Answer 1

Histmane blockers
COX inhibitors
Glucocorticoids

Question 2

What plays a central role in initiation of the inflammatory process?

Answer 2

Leukocytes

Question 3

What anti-histamine drug is part of the First generation H1 Antagonists and is a very sedating antihistamine?

Answer 3

Hydroxyzine

Question 4

What anti-histamine drug is a part of the Second generation H1 antagonist (non-sedating)?

Answer 4

Loratidine

Question 5

What anti-histamine drugs are H2 antagonists?

Answer 5

Cimetidine

Famotidine

Question 6

What are the physiological effects of Histamine?

Answer 6

Dilation of small blood vessels
Increased in capillary permeability
Stimulation of peripheral nerve endings

Question 7

Which histamine receptor mediates rapid vasodilation of small blood vessels, increase capillary permeability, irritation of the peripheral nerve endings, and bronchoconstriction?

Answer 7

H1 receptor

Question 8

What are the drugs called that block H1 receptors and are used to treat allergies?

Answer 8

anti-histamines

Question 9

Which histamine receptor mediates gastric acid secretion?

Answer 9

H2 receptors

Question 10

Who do anticholinergic side effects typically effect?

Answer 10

elderly

Question 11

What generation agents do not cross the BBB and therefore usually do not cause sedation and have a longer duration of action?

Answer 11

Second generation agents

Question 12

What drug has antiandrogen effects, inhibits CYP450 and interfere with the metabolism of other drugs, and inhibits hepatic microsomal drug metabolism enzymes?

Answer 12

Cimetidine

Question 13

What blockers can alter the bioavailability of a variety of drugs?

Answer 13

H2 blockers