Fluoroquinones

Question 1

What inhibits DNA gyrase or topoisomerase IV; this inhibits DNA replication and transcription

Answer 1

Fluoroquinolones

Question 2

Fluoroquinolones are most effective at treating infections caused by what?

Answer 2

aerobic gram negative bacteria

Question 3

What generation of Fluoroquinolones includes Nalidixic acid and targets a narrow spectrum?

Answer 3

1st generation

Question 4

What generation of Fluoroquinolones includes Ciprofloxacin and Norfloxacin and targets activity against aerobic gram negative and atypical bacteria?

Answer 4

2nd generation

Question 5

What generation of Fluoroquinolones includes Levofloxacin and targets increased activity against gram positive bacteria?

Answer 5

3rd generation

Question 6

What generation of Fluoroquinolones includes Moxifloxacin and targets activity against anaerobid and gram positive organisms?

Answer 6

4th generation

Question 7

What 2nd generation Fluoroquinolones has the best activity against P. aeruginosa and is commonly used in cystic fibrosis patients for this indication?

Answer 7

Ciprofloxacin

Question 8

What 3rd generation of Fluoroquinolones has excellent activity against S. pneumoniae respiratory infections?

Answer 8

Levofloxacin

Question 9

What is the main therapeutic use for Fluoroquinolones?

Answer 9

UTIs

Question 10

What is used for UTIs resistant to bactrim and fluoroquinolones; prophylactic prevention of UTIs?

Answer 10

Nitrofurantoin

Question 11

What is an adverse effect of Nitrofurantoin?

Answer 11

Hemolytic anemia