Principles of Neuropharmacology Flashcards
What is neuropharmacology
How drugs effect nerve cells
What is an action potentil
The stimulus that has the information
What happens to the neurotransmitters after the action potential
They are released
What happens after the neurotransmitters are released
They bind to receptors
What happens to the neurotransmitters that were released but didn’t binid to respeptors
They are reuptaked or degraded
What is reuptake
When extra neurotransmitters are absorbed back into the nerve cellWh
What is degradation
When extra neurotransmitters are broken down
What type of drugs are SSRIs (antidepressants) in terms of reuptake
They inhibit reuptake
What do reuptake ingibitor drugs cause
INCREASED stimulation and PROLONGED stimulation
What is the autonomic nervous system reffered to
The involuntary nervous system
Is the autonomic nervous system self-governing and automatic
Yes and yes
What does the autonomic nervous system regulate
HR, BP, EYES
What type of nerve fibers does the ANS have
ADRENERGIC and CHOLINERGIC
What are the sympathetic receptors
Adrenergic
What is the neurotransmitter for adrenergic receptors
Norepinephrine (NE)
What does bronchodilation do
It opens the air ways to allow more O2
Which receptors have alpha and beta receptors
Adrenergic
Is epinephrine selective
No
What are some uses of Epi
ANAPHYLAXIS, ASTMATICS, SHOCK, cardiac ARREST
Does epi have a slow or fast onset
Fast
What are the side effects/ adverse reactios to epi
Cardiac DYSRHYTHMIAS, PALPITATIONS, TACHYCARDIA, HYPERTENTION, DISSY, HEADACHE, AGITATION, HYPERGLYCEMIA
What type of receptors does the PNS have
Cholinergic
What is the neurotransmitter for cholinergic receptors
Acetylcholine (Ach)
What is mydriasis
Dialation of the pupils
What is miosi
Constriction of the pupils
What will an adrenergic blocker do to the airway
Broncoconstriction
What does a chronotropic drug do
It effects the heart RATE
What does a dromotropic drug do
It effects the CONDUCTION of the heart
What does a inotropic drug do
It affects the CONTRACTION of the heart
Why is it important to vasoconstrict when using the sympathic nervous system
It increases the BP which forces blood to the ORGANS
What are adrenergic drugs
They mimc the SYMPATHETIC nervous system
What are sympathomimetic drugs
They mimic the SYMPATHETIC nervous system
What are adrenergic blockers
They inhibit the SYMPATHETIC nervous system
What are sympatholytic drugs
They inhibit the SYMPATHETIC nervous system
What type of effect do sympatholytic drugs have
A cholinergic effect
What are cholinergics drugs
They mimic the PARASYMPATHETIC nervous system
What are parasympathomimetics
They mimic the PARASYMPATHETIC nervous system
What are anticholinergics
They inhibit the PARASYMPATHETIC nervous system
What are parasympatholytics
They inhibit the PARASYMPATHETIC nervous system
Can medications be more focused on one system (nervous system)
Yes
What is another name for a muscarinic
Cholinergic agonist
What system does bethanechol focus on
The bladder
When is bethanechol used
After surgeries to make you PEE
What type of drug is bethanechol
A CHOLINERGIC AGONIST
What type of effects do muchrooms have
A cholinergic effect (slows everything down)
Your pt is on a cholinergic agonist drug, should they have mushrooms
No, it could cause cardiovascular collapse
What type of drug is atropine
A cholinergic antagonist
What is the therapeutic use of atropine
A PREANESTETIC to prevent a dangerous drop in HR
What is the antibote to muscarinic poisoning
Atropine
What happens to the body in a sympathetic response
Eyes:
HR:
BP:
RR:
Lungs:
Blood vessels:
GI system:
Detrusor muscle:
Urinary spnicter:
Blood sugar:
Eyes: DIALATE
HR: INCREASES
BP: INCREASES
RR: INCREASES
Lungs: broncoDIALATION
Blood vessels: vasoCONSTRICTION
GI system: SLOW
Detrusor muscle: RELAXES
Urinary spnicter: CONTRACTS
Blood sugar: INCREASES
What happens to the body in a parasympathetic response
Eyes:
HR:
BP:
RR:
Lungs:
Blood vessels:
GI system:
Detrusor muscle:
Urinary sphincter:
Blood sugar:
Eyes: CONSTRICTION
HR: DECREASES
BP: DECREASES
RR: DECREASES
Lungs: broncoCONSTRICTION
Blood vessels: vasoDIALATION
GI system: SPEEDS UP
Detrusor muscle: CONTRACTS
Urinary spnicter: RELAXES
Blood sugar: DECREASES
