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primary species cram cards Flashcards

1
Q

rabbit diseases

Cryptosporidiosis

A

Cryptosporidium cuniculus

weanling rabbits most affected

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2
Q

pig diseases

swine influenza

A

orthomyxovirus

high morbidity (100%) but low mortality

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3
Q

pig diseases

Things to know about Clostridial enteritis

A

12hrs-4wks old (peaks at 3 days)

persistent diarrhea, clear fluid with necrotic debris

can die within 4-8 hours after exposure

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4
Q

rabbit diseases

things to know about Encephalitozoonosis

A

Encephalitozoon cuniculi

affects multiple species

brain and kidney, granulomas

microsporidian

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5
Q

in mice the MHC allele is located on what chromosome?

A

17

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6
Q

mouse diseases

4 important things about Murine Pneumonia virus

A

paramyxovirus

co-infection with Pneumocystis common

natural infection is subclinical in immunocompetent mice, dyspnea, listlesness, wasting in immunodeficient

self limiting in immunocompetent, and persistent in immunodeficient

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7
Q

rat models

BUF (Buffalo) rat is a model for

A

spontaneous autoimmune thyroiditis

transplantable Morris hepatoma

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8
Q

NHP diseases

things to know about Hepatitis A

A

Picornaviridae

chimps and cynos and owl monkeys susceptible but no CS

fecal-oral

zoonotic

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9
Q

rat model

Nude rat is a model for

A

t cell deficiency

autosomal recessive

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10
Q

rabbit biology

unique characteristics of the urinary system

A

unipapillate

can separate the tubutles iwth basement membrane intact

ectopic glomeruli are normal

CCMAMP

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11
Q

pig diseases

things to know about Colibacillosis

A

caused by pathogenic Escherichia coli

very young- hours old through post weaning

hypersecretory diarrhea

Edema disease

serious in younger pigs

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12
Q

rat diseases

2 things to know about Mycoplasma haemomuris

A

1- transmitted by Polyplax spinulosa

2) normally latent infection unless activated by immunosuppression or splenectomy

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13
Q

mouse diseases

name the three flagellated protozoans found in mice

A

Giardia muris,

Spironucleus muris,

Tritrichomonas muris

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14
Q

rat diseases

what Pneumocystis spp infects rats

A

Pneumocystis cainii

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15
Q

pig biology

describe the anatomic location of the thyroid and thymus

A

thyroid and thymus are inverted in their location

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16
Q

what stain is used to diagnose amyloidosis

A

Congo red

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17
Q

mouse diseases

what is the most common cestode found in mice

A

Rodentolepis nana or the dwarf tapeworm

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18
Q

pig biology

placentation in swine

A

diffuse epitheliochorial

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19
Q

NHP diseases

things to know about Cercopithecine herpesvirus 2

A

natural host= African green monkey

AKA Simian agent 8, used as safer antigen for B virus tests

alpha herpes virus, simplex virus

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20
Q

NHP diseases

things to know about mollusceum contagiosum

A

chimpanzees

waxy small tumors on face and extremities

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21
Q

NHP diseases

things to know about Streptococcus pneumoniae

A

in chimps starts as upper respirtory disease

think meningitis

fibrinopurulent leptomeningitis

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22
Q

list mouse caging material from most expensive to least

A

polyethermide, polycarbonate, polypropelene, polystyrene, polyethylene

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23
Q

which mouse species are resistant to dystrophic mineralization?

A

C57BL/6

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24
Q

mouse diseases

3 important things about Rodentolepeis nana

A

1- direct or indirect lifecycle

2- adults have scolex with 4 suckers and 20-27 rostellar hooks, eggs ahve 6 polar filaments

3- eggs do not survive well outside host

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25
Q

pig diseases

Things to know about the swine whipworm

A

Trichuris suis

diarrhea, dehydration

double operculated eggs

2-6mo pigs

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26
Q

NHP diseases

which pentastomes are found in NW

A

Porocephalus

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27
Q

rabbit diseases

things to know about Tyzzers disease

A

Clostritium piliforme

3-8 wk old rabbits

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28
Q

mouse diseases

6 important things about Helicobacter

A

1- chronic active hepatitis= H. hepaticus in immune disregulated mice

2- A/J are susceptible, BL6 are resistant

3- silver stain

4- TX by Amoxicillin, Metronidazole, Bismith for 2 weeks

5- other species are H. muridarum, rappini, rodentium, typhlonius, pylori, billus

6- transplacental transmission possible, also recommend foster at less than 24 hours

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29
Q

rat model

Gunn rat is a model for

A

jaundice

kernicterus

autosomal recessive

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30
Q

mouse diseases

5 important things about Citrobacter

A
  1. rectal prolapse
  2. saphyrophyte

3- DBA,NIH swiss, C57BL are resistant, A/J, C3H are susceptable

4- mucosal hyperplasia of descending colon, pathognomonic

5- causes transmissible colonic hyperplasia

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31
Q

NHP biology

common marmosets are more susceptible to which diseases and why?

A

bacterial

limited MHC class II

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32
Q

NHP diseases

things to know about Retroperitoneal fibromatosis associated herpesvirus

A

gammaherpesvirus, rhadinovirus

immunosuppression with SRV leads to retroperitoneal fibromatosis lesions

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33
Q

mouse diseases

4 important things about Syphacia

A

1- 11-15 day life cycle

2- diagnose by tape test

3- eggs are flattened on one side with pointed ends

4- infection is subclinical

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34
Q

NHP diseases

what is the most important intestinal parasite in NW NHP

A

Prosthenorchis elegans

nematode

cockroaches spred

lives in cecum or colon

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35
Q

rat model

LOU/C rat is a model for

A

myeloma

production of IgG autoantibody

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36
Q

rabbit diseases

lumbar fracture

A

L6-L7

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37
Q

pig diseases

things to know about Balantidium coli

A

zoonotic

ciliated protozoan

cecum and anterior colon

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38
Q

mouse diseases

5 important things about Giardia muris

A

1- infects duodenum of young and adult mice

2- does NOT cause diarrhea

3- moves in rolling/tumbling motion

4- elipsoidal cysts with 4 nuclei “monkey face”

5- C3H, SJL, CBA are susceptible while DBA/2, BALB/c and C57BL/6 are resistant

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39
Q

what mouse strains have a low natural prevalance of mammary tumors?

A

BALB/c

C57BL

AKR

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40
Q

rat diseases

2 things about rotaviruses in rats

A

most likely human in origin

only see clinical signs of diarrhea up to 12 days old then are resistant

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41
Q

rat diseases

What rat strain is most susceptible to Nephrocalcinosis

A

female BDIX rats

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42
Q

NHP diseases

things to know about Helicobacter

A

H. pylori

persistent lymphocytic gastritis

OW and NW

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43
Q

rat model

WF (wistar furth)

A

mononuclear cell leukemia

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44
Q

which mouse species are susceptible to dystrophic mineralization?

A

DBA/2 (epicardium)

BALB/c (epicardium)

C3H (myocardium)

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45
Q

describe the Bruce effect

A

strange male pheremones prevent implantation

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46
Q

dog models

which dog breed is a model for Wilson’s disease

A

Bedlington terriers

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47
Q

NHP diseases

things to know about Papiine herpesvirus 2

A

natural host=baboons

used as safter antigen in B virus tests

alpha herpes virus, simplexvirus

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48
Q

rat diseases

list 4 things to know about pneumonia virus of mice

A

paramyxoviridae

no clinical disease signs

wide host range

will burn out if no new susceptibles

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49
Q

what does (.) stand for in mouse nomenclature

A

congenic

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50
Q

Animal model

Male pattern baldness

A

Macaca arctoides

stump tailed macaque

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51
Q
A

Mycoptes musculinus

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52
Q

NHP diseases

things to know about Simian Foamy virus

A

retrovirus, spumavirus

high prevalence

zoonotic, but no clinical signs seen

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53
Q

Pig diseases

things to know about Glassers disease

A

Haemophilus parasuis

neuro, arthritis, respiratory

3wk-4mo

fibrinous pleuritis

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54
Q

describe the difference between the male and female submaxillary salivary gland

A

males has columnar epithelium with basal nuclei and a larger number of , females have cuboidal epithelium with central nuclei

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55
Q

NHP diseases

things to know about Cercopithecine herpesvirus 9

A

host species= macaques

AKA simian varicellavirus

alphaherpes virus, varicellovirus

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56
Q

Lagothrix are animal models for:

A

cardiovascular research

Hepatitis

Toxoplasmosis

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57
Q

which mouse strains have a high natural prevalance of mammary tumors?

A

C3H

A

DBA/2

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58
Q

mouse diseases

pathology of Polyomavirus in mice

A

induces tumors in mice affected as neonates typically 2-12 months post experimental infection

natural infections are asymptomatic

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59
Q

Animal model

Hep B and C

A

Chimps

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60
Q

TALEN stands for

A

transcription activator like effector nucleases

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61
Q

strain specific lesions for A/J

A

congenital defects such as cleft palate, open eyelids, polydactyly

progressive muscular dystrophy due to dysferlin mutation

systemic amyloidoisis

lung tumors

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62
Q

NHP diseases

things to know about Macacine herpesvirus 3

A

Beta herpesvirus, cytomegalovirus

AKA Rhesus cytomegalovirus

disease only occurs in immunocompromised or with intrauterine infection

“Owl eye” intranuclear inclusions

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63
Q

what species has a hemochorial placenta and how may layers does it have?

A

human, rodents

3

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64
Q

mouse models

induction agent for IBD in micee

A

dextran sodium sulfate (DSS)

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65
Q

rat diseases

fow many strains of rat parvoviruses are there and describe the common clinical syndromes

A

4 of them, Kilham’s: Toolan’s H-1: rat parvovirus: rat minute virus

pups of persistently infected dams are protected by maternal antibody, infection of non-immune pregnant femals results in persistent infection of pupb

post weanling rats that are exposed develop subclinical infections

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66
Q

rat model

Obese SHR

A

Type 4 hyperlipoproteinemia

autosomal recessive

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67
Q

rat diseases

list clinical signs of rat theilovirus

A

immunocompetent rats= no clinical signs

in immunodeficient rats= persistet shedding

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68
Q

NHP diseases

things to know about Hepatitis E virus

A

Hepeviridae

cynos

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69
Q

rabbit diseases

buphthalmia

A

autosomal recessive trait with incomplete penetrance

individuals over 3-4 months of age

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70
Q

animal model

multiple sclerosis/ experimental allergic encephalomyelitis

A

Callithrix jacchus

intradermal injection of homologous myelin basic protein

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71
Q

rabbit diseases

things to know about myxoma virus

A

endemic in sylviagus and fatal in oryctolagus

flat myxomas lesions in skin

fleas and mosquitoes transmit

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72
Q

mouse diseases

what is the most common pin worms in mice

A

Syphacia obvelata

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73
Q

characteristics of 129 mice

A

testicular teratomas

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74
Q

NHP diseases

what is the only pathogenic ameba in NHP

A

Entamoeba histolytica

cause flask shaped ulcers

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75
Q

NHP diseases

things to know about Campylobacter

A

C. jejuni and coli

high prevanlence but often subclinical

infections are self limiting and reinfection is frequent

OW and NW

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76
Q

pig diseases

Things to know about porcine rotavirus

A

effects 7-28 day old piglets

low mortality

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77
Q

pig diseases

things to know about swine dysentery

A

Brachyspira hyodysenteriae

malabsorptive mucohemorrhagic diarrhea

seldom apparent in piglets less than 3wks old

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78
Q

rabbit diseases

mandibular prognathism

A

autosomal recessive trait with incomplete penetrance

maxilla is short relative to mandible

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79
Q

rabbit diseases

ulcerative pododermatitis

A

Staph aureus

caging

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80
Q

what hormone is responsible for gametogenesis in mice

A

FSH

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81
Q

NHP disease

things to know about Mycobacterium avium-intracellulare

A

saprophytic

nontuberculoid mycobacteria

causes disease in SIV infected macaques

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82
Q

rabbit model

induction agent for allergic asthma

A

ovalbumin in complete freunds adjuvant

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83
Q

NHP diseases

things to know about Pasteurella multocida

A

pneumonia, otitis medi

recent shipping, poor condition animals

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84
Q
A

Myobia musculi

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85
Q

rat model

(Lewis) LEW rat is a model for

A

multiple sclerosis

various experimentally induced autoimmune disease

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86
Q

mouse diseases

name 5 important facts about the parvo viruses that infect mice

A

immunosuppressive properties

natural infections are asymptomatic

NS vs VP for differentiation

MPV more persistent than MVM

experimental infection of MVM in neonates results in renal and intestinal hemorrahge and death; experiemntal infection with MPV does not result in any clinical signs, just persistent lymphocytic infection

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87
Q

rabbit diseases

things to know about Colibacillosis

A

E. coli strain O15:H and O103:H2 are most virulent strains in european rabbits 4-5 wks of age, high mortality, other strains cause less severe disease

1-2 week old suckling rabbit high mortality

vilous atrophy and fusion in the ileum, cecum and colon

antibiotics not recommended- hemolytic uremic syndrome can develop

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88
Q

Canine diseases

what are the components of the canine infectious respiratory disease complex

A

Bordatella

Strep equi spp zooepidemicus

Mycoplasma

canine adenovirus type 2

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89
Q

which animals have two cervices

A

rat, rabbit, chinchilla, hamster, opossum, woodchuck

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90
Q

mouse diseases

clinical signs of infection with mamallian orthoreoviruses

A

severe pantropic infection in infant mice

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91
Q

what is unique about the rodent kidney vs most mammals?

A

it is unipapillate making catheterization easier

vs most mammals which are multipapillate

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92
Q

pig models

what breed of pig is a model vor vonWillebrand’s disease

A

Poland China

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93
Q

NHP diseases

things to know about Saimiriine herpesvirus 1

A

natural host= squirrel monkeys

aberent hosts= other new worlds

alphaherpes virus, simplexvirus

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94
Q

strain specific lesions for DBA

A

cardiac calcinosis

glaucoma

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95
Q

rat diseases

cestodes found in rats

A

Rodentolepis nana

Hypenolepis diminuta

Taenia taeniaformis

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96
Q

NHP diseases

things to know about Orthomyxoviridae

A

NHPs can serve as experimental model

highly contagious, OW develop upper respiratory clinical signs

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97
Q

rabbit diseases

rabbit pox virus

A

rare

fatal

develop blepharitis, conjunctivitis, and keratitis with corneal ulcers, occasionaly rash or skin lesions present

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98
Q

mouse diseases

name the two reoviruses that infect mice

A

Mammaliam orthoreoviruses

Group A rotaviruses

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99
Q

most common dermatophyte found in mice

A

Trychphyton mentagrophytes

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100
Q

NHP diseases

describe the life cycle of Plasmodium

A

in host has hepatic phase and erythrocytic phase (known as sporozoites and merozoites leading to production of macro and micro gametocytes) Gametocytes are taken up by mosquitoes and the sexual phas begins, form oocyst and then sporozoites which are then spread to host by mosquito

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101
Q

rat diseases

What neoplasm if the second most common tumor type of F344 rats?

A

Pituitary adenoma

Testicular teratoma is 1st

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102
Q

characteristics of C3H/He mice

A

agouti

blind due to rd1 mutation

corneal opacities

myocardial and skeletal mineralization

age related alopecia

exogenous murine mammary tumor virus

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103
Q

strain specific lesions of 129 mice

A

acidophilic macrophage pneumonia

hyalinosis in other epithelia

megaesophageous

polyarteritis

testicular teratomas

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104
Q

animal model

Hemochromatosis

A

Callithrix jacchus

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105
Q

rabbit biology

three genus in family leporidae

A

oryctolagus

lepus

sylvilagus

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106
Q

Animal models

toxoplasmosis

A

Lagothrix- woolly monkey

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107
Q

rabbit biology

what is unique about the rabbit cardiovascular system

A

tricuspid valve has 2 cusps

SA node is easy to identify

aortic nerve responds to baroreceptors only, not chemoreceptors

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108
Q

rabbit models

of infectious disease

A

Syphilus

papillomatosis

colibacillosis (RITARD)

Campylobacter (RILT)

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109
Q

rabbit biology

name the two unsual anatomic features of the intestine of the rabbit

A

sacculus rotundus (cecil tonsil ( ileum empties into)

fusus coli- distal portion of colon, smaller diameter regulates hard/soft pellet excretion

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110
Q

NHP diseases

things to know about human herpes virus 1,2

A

natural hosts= humans

aberent hosts= NW particullarly marmosets

alphaherpes virus, simplexvirus

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111
Q

animal model

Gilbert’s syndrome

A

southdown sheep

fasted bolivian squirrel monkeys

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112
Q

NHP diseases

which nasal mite is found in NW

A

Pneumonyssoides

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113
Q

pig models

which breed of pig is a model for high membranous ventral septal defect?

A

yucatan

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114
Q

define a purified diet

A

each nutrient is derived from a specific ingredient

for example, protein from casein or soy, carbohydrate from corn starch or sucrose, fat from lard or corn oil

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115
Q

rat diseases

rat bladder threadworm

A

Trichosomoides crassicauda

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116
Q

rat diseases

What neoplasm is the most common spontaneous tumor of aged Sprague Dawley and Wistar Han rats?

A

Pituitary adenoma

Mammary tumors are 2nd

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117
Q

pig diseases

Things to know about inclusion body rhinitis

A

caused by Porcine cytomegalovirus

nursing/newly weaned piglets

growing pigs are exposed to the virus in the environment and produce their own antibodies, causes abortion when pregnant adult animals are exposed for the first time

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118
Q

mouse diseases

4 important things about Spironucleus muris

A

1- infects crypts of Lieberkuhn, duodenum

2- pathogenic for young, stressed or immunocompromised mice

3- age 3-6 weeks most susceptable

4- moves in zig zag motion

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119
Q

pig diseases

Things to know about sarcoptic mange

A

Scaroptes scabiei var. suis

acute pruritis

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120
Q
A

Radfordia ensifera (rats)

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121
Q

NHP

humans are most likely to be infected with which species of Plasmodium

A

vivax, falciparum,

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122
Q

mouse diseases

what are the primary differences between MAdV-1 and 2

A

1 causes fatal multisystemic infection in suckling mice, 2 is typiclaly asymptomatic but is enterotropic in mice less than 3 wks of age

1 causes necrosis of liver, spleen, intranuclear inclusions; 2 causes intranuclear inclusion in mucosal epithelial cells of small intestine

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123
Q

mouse diseases

4 important things about Pseudomonas aeurogenosa

A

1- clinicall silent in immunologically competent animals, opportunist

2- chronically inhabits nasopharynx, GI tract,

3- dx by clinical signs and history of immunosuppression

4- found in water, acidification to 2.5pH or hyperchloriation to 10 ppm of drinking water

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124
Q

Animal model

visceral Leishmania

A

Chlorocebus aethiops

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125
Q

Animal models

model for HIV

A

baboons and pig tailed macaques will develop disease and immunosuppression with HIV 2 infection

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126
Q

which mice species are prone to retinal degeneration?

A

c3H and CBA

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127
Q

what is the most common hematopoietic malignancy

A

lymphoma

lymphocytic leukemia originating from the thymus

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128
Q

animal model

motion sickness

A

Saimiri

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129
Q

rat diseases

3 important things to know about Pseudomonas aeruginosa

A

widely distributed in water, soil, sewage

wide host range

rarely see unless immunosuppressed

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130
Q

NHP diseases

things to know about Poliovirus

A

Picornaviridae

Macaques serve as experimental model

typically no CS

if no immune responce can see poliomyelitis and skeletal muscle atrophy

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131
Q

dog models

which breed is a model for Diabetes mellitus

A

Keeshond

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132
Q

mouse diseases

list the common coccidians found in mice

A

Eimeria falciformis

Klosiella muris

Cryptosporidium muris, parvum

Entamoeba muris

Encephalitozoon cuniculi

Toxoplasma gondii

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133
Q

dog models

gray collie syndrome

A

cyclie hematopoiesis

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134
Q

use of FVB mice in genetic engineering

A

microinjection into large pronucleus

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135
Q

characteristics of C57BL/6 mice

A

hydrocephalus

hippocampal neurodegeneration

micropthalmia and anophthalmia

age related cochlear degeneration

malocclusion

pulmonary proteniosis

epithelial hylanosis

late onset amyloidosis

TH1 skewed immune response

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136
Q

rabbit diseases

things to know about rotavirus infection

A

yes, rabbits have one too

mild diarrhea, mucoid

weaning age most susceptible

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137
Q

Animal models

Leprosy

A

Cercocebus torguatus atys- sooty mangaby

Dasypus novempictus- armidillo

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138
Q

characteristics of mouse urine

A

creatinine is excreted instead of creatine
taurine present, tryptophan is absent

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139
Q

NHP diseases

things to know about monkey adenovirus

A

Adeniviridae

respiratory and enteric disease but subclinical infection common

used in research as gene delivery method

in immunocompromised animals=necrotizing pancreatitis

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140
Q

pig diseases

Things to know about Leptospirosis

A

caused by Leptospira interrogans- serovars pomona and bratislava

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141
Q

pig management

recomendations for vaccination

A

erysipelas and leptospirosis

breeding add Porcine parvovirus, bordatella, pasturella, e coli

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142
Q

rat models

Brown Norway (BN) rat is a model for

A

inducible, transplantable myeloid leukemia

hydronephrosis

bladder carcinoma

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143
Q

rabbit diseases

dermatophytosis

A

trichophyton mentagrophytes

no pruritis

zoonotic

asymptomatic carriers

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144
Q
A

Syphacia obvelata (mice)

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145
Q

NHP diseases

things to know about Moraxella catarrhalis

A

epistaxis and mucohemorrhagic discharge

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146
Q

rat diseases

most common pinworm

A

Syphacia muris

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147
Q

rat diseases

What are the three gastrointestinal bacterial pathogens of rats?

A

Clostridium piliforme

Salmonella entereditis

Helicobacter

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148
Q

rat diseases

list the two corona viruses of rats

A

Parkers rat corona virus

Sialodacryoadenitis virus

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149
Q

pig diseases

list the causative agents of atrophic rhinitis

A

Bordetella bronchiseptica and Pasturella multocida

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150
Q

Pig diseases

important things to know about Mycoplasmal polyserositis

A

caused by Mycoplasma hyorhinis

3-10wks

aerosol spred, assoicated with stress

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151
Q

NHP diseases

things to know about yellow fever

A

flaviviridae

asymptomatic in OW, NW are susceptible

mosquitoes

zoonotic

Councilman bodies (eosinophilic inclusions)

Torres bodies (eosinophilic intranuclear inclusions)

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152
Q

Animal models

natural hosts for SIV

A

african green, sooty mangabeys, and mandrills

cause disease (AIDS like) in macaques

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153
Q

mouse diseases

3 important things to know about K virus

A

1) tropism for vascular endothelium
2) persistent infection in adults and infants in the renal tubular epithelium
3) intranuclear inclusions in vascular endothelium of small intestine and brain, lung liver

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154
Q

canine diseases

zoonotic disease associated with Ancylostoma caninum

A

cutaneous larval migrans

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155
Q

what is the most common ectoparasite in mice

A

Mycoptes musculinis

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156
Q

rat diseases

4 important things to know about Clostridium piliforme

A

Tyzzers disease

affects numerous species

usually clinically silent, unless recently weaned or immunosuppressed

liver heart GI lesions

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157
Q

rat model

COP (Copenhagen) rat is a model for

A

prostate adenocarcinoma

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158
Q

rabbit diseases

proliferative enteropathy

A

lawsonia intracellularis

weanlings most commonly affected

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159
Q

pig diseases

Things to know about Swine Enzootic Pneumonia

A

caused by Mycoplasma hyopneumoniae

3-6 mo old infected (most common in grower and finisher pigs)

central role in porcine respiratory disease complex

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160
Q

NHP diseases

things to know about Tanapox

A

yabapoxvirinea

host=african green monkey, infects macaques

both intracytoplasmic and intranuclear inclusion bodies

in the epidermis

161
Q

pig diseases

Things to know about porcine reproductive and respiratory syndrome

A

arterivirus

clinical signs as name suggests

162
Q

NHP diseases

things to know about Klebsiella pneumoniae

A

normal flora of upper and lower GI tract

can infect upper respiratory tract and cause disease

pneumonia, air saculitis, septicemia, peritonitis

OW and NW

163
Q

Animal model

Bancroftian filariasis

A

Presbytis cristatus (silvered leaf monkey)

164
Q

what species do not have a gallbladder

A

rat, horse, camel, dophin, elephant, pigeon, some hamsters (Chinese and European do not, Siberian and Russian do)

165
Q

mouse diseases

4 important things about Aspicularis

A

1- 23-25 day life cycle

2- diagnose by fecal float

3- eggs are ellipsoidal

4- require 6-7 days incubation to become infective

166
Q

Pig diseases

List 4 diseases that cause arthritis in pigs

A

Haemophilus parasuis (Glassers disease)

Streptococcus suis

Erysipelas rusiopathiae

Mycoplasma polyserositis

167
Q

Animal model

Hep A and E

A

Owl, chimps, marmosets

168
Q

describe the Lee Boot effect

A

estrus supression in group housed females

169
Q

NHP diseases

things to know about Salmonellosis

A

S. typhimurium, choleraseuis, anatum, stanley, derby, and oranienburg

starts out as GI but can progress to septicemia in neonates, abortion,and pyelonephritis

carrier state can develop, especially if treated with antibiotics

170
Q

mouse diseases

name the two parvo viruses of mice

A

minute viruse of mice

mouse parvovirus

171
Q

what CNS ventricular structure does the rat lack

A

foramen of Magendie

172
Q

mouse diseases

4 important things about Staphylococcus

A
  1. aureus is highly pathogenic while epidermidis is nonpathogenic
  2. in nude mice, aureus = furunculosis, gland absecesses
  3. C57/BL6, C3H, DBA, BALB/c are susceptible
  4. suppurative ulcerative and necrotic dermatitis in young mice
173
Q

rabbit diseases

things to know about rabbit hemorrhagic disease

A

calicivirus

3 clinical syndromes: peracute/sudden death

acute/ anorexia, depression, ocular hemorrhage and epistaxis

subacute/ milder and most survive

periportal hepatic necrosis is only consistent microscopic lesion

174
Q

what are the primary uses of 129 mice in genetic engineering

A

source of embryonic stem cells

175
Q

NHP diseases

clincial disease seen with Tritrichomonas mobilensis

A

diarrhea in squirrel monkeys

176
Q

Animal model

Gonorrhea

A

Pan troglodytes

177
Q

Mouse diseases

4 important things about CAR bacillus

A

1- more significant in rats

2- natural clinical disease is rare

3-silver stain (Warthin-Starry) for diagnosis

4- co pathogen with SV and PVM

178
Q

pig diseases

Things to know about Porcine parvovirus

A

when sows are exposed at <70 days gestation

natural exposure of gilts entering breeding herd leads to development of transferable immunity

179
Q

animal model

labor and pelvic organ prolapse

180
Q

rabbit diseases

things to know about Psoroptes cuniculi

A

inner surfaces of external ear

otoacariasis (ear canker)

181
Q

Animal models

Malaria

A

Owl and Squirrel monkeys

182
Q

rabbit models

infection with what agent leads to development of hypercalcemic nephropathy?

183
Q

rabbit diseases

things to know about the rabbit pinworm

A

Passalurus ambiguus

perpatent period 56-64 days, eggs are immediately infective

184
Q

animal models

lymphocytic Thyroiditis

A

Callithrix jacchus

185
Q

rat diseases

4 important things to know about Corynebacterium kutscheri

A

pseudotuberculosis

multiple randomly distributed abscesses in lungs, liver (rat=lungs)

latent infections in submaxillary lymphnode

disease more frequent in older animals

186
Q

rat diseases

clinical disease with reovirus?

A

No, only seroconvert

187
Q

NHP models

Cercocebus atys

A

sooty mangaey

AIDS/SIV

leprosy

188
Q

Animal models

Varicella

A

Erythrocebus patas

Chlorocebus aethiops

189
Q

NHP diseases

things to know about Simian T-lymphotropic virus

A

retrovirus, deltaretrovirus, type C retrovirus

OW, not NW (Baboons, AG, and macaques)

usually subclinical, latency, develop tumors

190
Q

mouse diseases

5 important things about Mycoptes musculinis

A

1- found in the inguinal region, abdomen, back but also on head and neck

2- causes pruritis

3- 8-14 day life cycle

4- feed on superficial epidermis

5- heavily chitinized, “boxing gloves” on last two legs

191
Q

NHP models

Chlorocebus

A

grivet, vervet

infectious diesease- yellow fever, plague, leprosy, hepatitis legionnaires disease, varicella

192
Q

rat biology

which hormonal reproductive effects are seen in rats

A

Lee Boot effect (minimally). no Bruce or Whitten

193
Q

NHP diseases

things to know about Molineus elegans

A

small intestine of NW (particullarly capuchin and squirrel)

nematode

194
Q

animal models

stress

A

Saimiri (naturally high cortisol levels)

195
Q

Callithrix are animal models for:

A

Parkinson’s disease

Multiple sclerosis

Hemochromatosis

196
Q

rat model

F-344 is a model for

A

toxicology

inbred by NAtional Toxicology Program

197
Q

rat diseases

which strains are most susceptible to chronic progressive nephropathy?

A

F344

Sprague Dawley

198
Q

how many toes does the mouse have on each foot

A

5 on front and 5 on back

199
Q

mouse diseases

important things to know about LDHV (lactate dehydrogenase elevating virus)

A

Arteriviridae

asymptomatic, disease requires immunosuppression

transmitted via infected biologicals

LDH can be 5-20x normal

C58, AKR develop paralytic syndrome which is age dependent

passage through rats eliminates from biologicals

200
Q

NHP diseases

things to know about Macacine herpesvirus 5

A

ADA rhesus rhadinovirus

gammaherpesvirus, rhadinovirus

lymphadenopathy

SIV immune mediated anemia

201
Q

rabbit diseases

things to know about papillomavirus infections

A

cottontail (shope) papillomavirus

horny warts,

cottontail rabbits are natural host

arthropod spread

oncogenic (squamous cell carcinomas)

used to study oncogenic virus biology

202
Q

NHP diseases

name the 2 trematodes found in NHP

A

Gastrodiscoides hominis

Schistosoma spp

203
Q

NHP diseases

things to know about Mycobacterium Leprae

A

chronic granulomatous disease affecting the skin and peripheral nerves with lesions preferentially occuring in cooler areas

sooty mangaby (Cercocebus atys)

and chimpanzees

204
Q

rabbit diseases

intestinal coccidiosis

A

Eimeria

post weanling rabbits most likely to experience mortality

suckling rabbits are considered resistant

vaccine sprayed into nest box when rabbits are 25 days of age

205
Q

rabbit diseases

things to know about hydrocephalus

A

single autosomal recessive

hypovitaminosis A

206
Q

NHP diseases

which species of Plasmodium are NW NHP most likely to be infected with?

A

simium, brazilianum

207
Q

pig biology

what is unique about the pig lymphnode?

A

it is inverted, with germinal centers located in the internal portion of the node

similar to elephant, rhino, dolphin, hippo, and warthog

208
Q

Animal model

toxemia of pregnancy

A

Erythrocebus patas

209
Q

animal models

Strabismus

210
Q

NHP diseases

things to know about Encephalomyocarditis virus

A

Picornaviridae

rodents are carriers

baboons

usually found dead

211
Q

NHP diseases

most susceptible NHP to Giardia

A

macaque with SIV

212
Q

describe the changes that occur in the adrenal glands in mice

A

X-zone between medulla and cortex in immature males and young virgin females

213
Q

Canine diseases

which serovars of Leptospirosis are dogs most commonly infected with?

A

Grippotyphosa, pomona, Bratislava

215
Q

Canine diseases

things to know about Canine herpes virus

A

turkey egg kidneys

rapidly fatal disease in puppies

216
Q

rat diseases

3 things about hantavirus

A

bunyviridae

rodents are natural reservoir

infections are chronic and subclinical

217
Q

which species have an epitheliochorial placenta and how many layers does it have

A

cow, pig, horse

6 layers

218
Q

rabbit diseases

list the three pox viruses found in rabbits

A

myxoma virus

rabbit (shope) fibroma virus

rabbit pox virus

219
Q
A

Aspicularis tetraptera

220
Q

Which mouse strains are most susceptible to amyloidosis?

221
Q

orbital sinus vs plexus

A

mice have sinus rats have plexus

222
Q

Canine diseases

list the most common roundworm of dogs

A

Toxascaris canis

Toxascaris leonina

223
Q

pig diseases

Which organisms are responsible for coccidiosis in pigs?

A

Eimeria

Cryptosporidium parvum

Isospora suis

5-10 days Or suckling and recently weaned pigs

mild disease

224
Q

rabbit diseases

which gamma herpes viruses have been isolated from cottontail rabbits

225
Q

rat diseases

What is the most important disease of aging rats

A

chronic progressive nephropathy

226
Q

rabbit diseases

splay leg

A

simple autosomal recessive inheritance

unable to adduct typically hindlimbs

227
Q

NHP diseases

things to know about Lawsonia intracellularis

A

proliferative enteritis

228
Q

NHP diseases

list the 2 cestodes (tapeworms) found in NHP

A

Spargana

Echinococcus

229
Q

which mouse strain has a high incidence of thymic lymphoma from murine leukemia retrovirus

230
Q

Animal model

Parkinson’s Disease

A

Callithrix jacchus

MPTP

231
Q

rat diseases

4 things to know about Clostridium piliforme

A
  1. Tyzzer’s disease
  2. rats less commonly affected that mice
  3. peracetic acid is prefered disinfectant
  4. intestine, liver heart in rats (mice no heart)
232
Q

NHP diseases

which nasal mite is found in OW NHP

A

Pneumonyssus

233
Q

pig diseases

things to know about pig lice

A

Haematopinus suis

sucking lice

pruritis

234
Q

what does / stand for in mouse nomenclature

235
Q

mouse diseases

4 important things about Myobia musculi

A

1- 23 day life cycle

2- cause of hypersensitivity

3- one empoidial claw

4- found on head, neck, and shoulder regions

236
Q

NHP diseases

things to know about Nocardia spp

A

saprophytes

multinodular areas of consolidation of pulmonary lesions

look like coccidiomycoides or TB

237
Q

rabbit diseases

Clostridium difficile

A

affect ileum and jejunum instead of cecum

I

238
Q

NHP diseases

things to know about Kyasanur Forest Disease

A

flavivirus

Bonnet macaques are model

ixodid ticks spred

239
Q

rat model

Brattleboro rat is a model for

A

diabetes insipidus (autosomal recessive)

240
Q

NHP diseases

things to know about Histoplasma capsulatum

A

think baboons and skin touching the ground

241
Q

rat diseases

three things to know about Salmonella enterica

A

clinical signs are rare and unspecific

hepatitis with white spots

culture on selenite broth, brilliant green or MacConkey agar

242
Q

define a chemically defined diet

A

formulated with very basically defined ingredients, ie specific animo acids, sugars, triglycerides, and essential fatty acids

243
Q

rat models

BB/Wor is a model for

A

juvenille insulin dependent diabetes mellitus

244
Q

NHP diseases

things to know about yatapox

A

yabapoxviridea

macaques and baboons

zoonotic

SQ masses

245
Q

mouse diseases

list the two herpes viruses that infect mice

A

mouse cytomegalovirus (Beta herpes)

mouse thymic necrosis virus

246
Q

rabbit biology

describe the rabbit estrous cycle

A

they do not have one, induced ovulator

247
Q

rabbit diseases

things to know about Enterotoxemia

A

caused by Clostridium spiroforme (primary pathogen)

young rabbits/change in gut flora

248
Q

pig models

name the two primary uses for swine

A

surgical models

xenotransplantation

249
Q

NHP diseases

things to know about simian parvirus

A

parvoviridae

erythrocytic tropism

potential zoonosis

fulminant hepatitis and rheumatoid arthritis

250
Q
A

Radfordia affinis (mice)

251
Q

characteristics of FVB mice

A

blind due to homozygosity at rd1 allele

prone to seizures

prone to persistent mammary hyperplasia

252
Q

rat diseases

5 things to remember about CAR bacillus

A
  1. overt disease is uncommon
  2. wide host range
  3. clinical signs and gross lesions are indistinguishable from Mycoplasma
  4. silver stain
  5. forms large bronchial abscesses
253
Q

Pig diseases

Things to know about Erysipelas rhusiopathiae

A

diamond skin disease

3mo-3ys of age (growing or adult)

acute=septicemia and death

chronic= enlarged stiff joints, diamond shaped lesions

carriers are source, shed in feces

zoonotic

255
Q

describe the Witten effect

A

estrous induced by introduction of male pheremones

256
Q

NHP diseases

things to know about Shigella

A

S. flexneri, boydii, sonnei

both OW and NW

think diarrhea and gingivitis (also abortion and air sac infection)

large intestine

culture on three successive days

257
Q

rabbit models

induction agent for model of inflammatory bown disease

A

dinitrochlorobenzene (DNCB)

258
Q

consomic

A

chromosome substitution

259
Q

rabbit diseases

things to know about malignant lymphoma

A

tetrad of lesions, kidneys-splemonegaly- lymphadenopathy

260
Q

rat biology

estrous cycle of the rat

A

4-5 days

continuously polyestrous

261
Q

NHP diseases

things to know about rotaviruses

A

reoviridae

self limiting watery diarrhea

262
Q

rat diseases

What is the suspected cause of auricular chonritis?

A

immune mediated reaction to Type II collagen

263
Q

animal model

Spongiform Encephalopathy

264
Q

rat diseases

3 things to know about Corynebacterium kutscheri

A
  1. in rats most commonly affects lungs (multisystemic in mice)
  2. can cause persistent asymptomatic infections
  3. methenamine silver stain
265
Q

rat diseases

What are the 6 bacterial respiratory pathogens?

A

Streptococcus pneumoniae

Corynebacterium kutcheri

CAR

Mycoplasma pulmonis

Pasturella pneumotropica

Streptobacillus moniliformis

266
Q

uses of C57BL/6 in genetic engineering

A

most often used background strain

267
Q

rabbit biology

name the salivary gland that does not have a human counterpart

268
Q

strain specific lesions of BALB/c

A

epicardial mineralization and cardiomyopathy

imperforate vagina and mucometra

B cell lymphoma/reticulum cell sarcoma

mammary adenocarcinoma

269
Q

Rat biology

What is the name of the gland found in the rostral nasal cavity of the rat that contributes to maintenance of mucous blanket covering the ciliated respiratory surfaces

A

Steno’s gland

seems to be unique to the rat

270
Q

NHP models

Erythrocebus patas

A

Patas monkeys

pregnancy toxemia

271
Q

rat diseases

which rat strain is most susceptible to myocardial degeneration/fibrosis

A

aged Sprague Dawley

272
Q

mouse diseases

4 important things about Clostridium piliforme

A
  1. Tyzzers disease
  2. C57CL/6 resistant, DBA, CBA susceptible
  3. environmental decontamination difficult

4 trifecta of clinical signs (GI, heart, liver) heart rare in mice

  1. pickup sticks on silver stain
273
Q

rabbit diseases

scarptes scabiei

A

pruritic

burrowing mite

274
Q

rat diseases

Which rat strain is most prone to testicular neoplasms

275
Q

NHP disesases

things to know about macacine herpes virus 1

A

AKA B virus

alpha herpes virus, simplexvirus

natural host=macaque

aberent host= humans

276
Q

rat diseases

2 things to know about Sendai virus in rats

A
  1. paramyxovirus
  2. asymptomatic and self limiting in rats, unlike in mice
277
Q

what species have an endotheliochorial placenta and how many layers does it have

A

dog, cat

4

278
Q

rat model

ACI rat is a model for

A

congenital genitourinary anomalies

prostatic adenocarcinoma

279
Q

rat diseases

Which rat strain is most susceptible to polyarteritis nodosa

280
Q

rat biology

significance of left azygous vein in pigs

A

drains intercostal vessels into coronary sinus

different from other mammals where it enters the precava

281
Q

mouse diseases

6 important things to know about LCMV

A

Arenaviridae

4 biotypes (1. late disease 2. cerebral 3. mortality/neonatal runting 4. viscerotropic)

non-cytolytic/ minimally pathogenic but experimental intracerebral injection can cause disease

ZOONOTIC

think hamsters for amplification

prototype for T lymphocyte mediated immune injury

282
Q

NHP diseases

things to know about Hepatitis B virus

A

Hepadnaviridae

Chimps

283
Q

NHP diseases

things to know about monkeypox

A

orthopox

papules leading to vesicular rash, pock lesions (including hands and feet)

intracytoplasmic inclusion bodies

284
Q

rabbit diseases

things to know about Pastureloosis

A

head tilt

snuffles

weanlings

suppurative inflammation

use SPF rabbits

285
Q

NHP diseases

things to know about Rhesus papillomavirus

A

Papillomaviridae

hyperplasiaof stratum spinosum and corneum with spontaneous resolution

286
Q

mouse diseases

what are 3 important things about mouse herpes viruses

A

1) natural infections are asymptomatic, no matter the strain
2) persist in the salivary glands
3) pathology of cytomegalovirus is megalocytes with eosinophilic intranuclear inclusions in cervical salivary glands. pathology of mouse thymic cirus is thymic necrosis with intranuclear herpetic inclusions

287
Q

pig diseases

Things to know about Pleuropneumonia

A

Actinobacillus pleuropneumoniae

less than 6mo, peak mortality 10-16 weeks

severe pleuropneumoniae, sudden onset, high mortality and high morbidity

can become chronic or carrier forms

288
Q

rat diseases

list 3 things you should know about Streptococcus pneumoniae

A
  1. usually asymptomatic
  2. fibrinopericarditis, fibrinopleuritis are classic lesions
  3. Optochin test (zone of growth inhibition on blood agar plates)

and Neufeld-Quellung reaction- swelling of capsule

289
Q

characteristics of BALB/c

A

males pugilistic

dystrophic epicaridal mineralization

auricular thrombosis

corneal opacities

resistant to spontaneous amyloidoisis

TH2 skewed immune response

290
Q

rabbit diseases

list the three gamma herpes viruses of rabbits

A

leporid herpesvirus 1,2,3

291
Q

rat biology

describe the biology of the salivary glands in rats

A

parotid- serous

submaxillary/submandibular= mixed

sublingual= mucous

292
Q

mouse diseases

4 important things about Sendai virus

A

paramyxovirus

no persistent state in immunocompetent mice

C57 highly resistant; DBA/2 are susceptable

bronchial and interstitial pneumonia

293
Q

Saguinus are animal models for:

A

Viral hepatitis

colonic adenocarcinoma

IBD

294
Q

pig diseases

THings to know about Transmissible Gastroenteritis

A

Coronavirus

all ages, <2wks severe signs

diarrhea and vomiting

295
Q

Polypax serrata is found in what species of rodents and is the vector for what blood borne parasite

A

mouse, Mycoplasma coccoides

296
Q

CrISPR stands for

A

clustered interspaced short palindromic repeats

297
Q

rabbit diseases

which gamma herpes viruses cause disease

A

leporid herpesvirus 3, lymphoproliferative disease with lymphoid infiltration of many organs

298
Q

mouse diseases

what organisms are known for causing white spots on the mouse liver

A

Corynebacterium

Yersiniosis

Salmonellosis

Tyzzers

Ecromelia

Reovirus

MHV

Pasturella

Helicobacter

299
Q

NHP diseases

NHP most likely to be infected with Cryptosporidium spp

A

immunosuppressed macaques

300
Q

canine diseases

what is the hookworm found in dogs?

A

Ancylostoma caninum

Ancylostoma braziliense

301
Q

mouse diseases

4 things about Encephalitozoon cuniculi

A

1- think rabbits and brain/neuro and kidney

2- no clinical signs in mice

3- microsporidian

4- stain with either Giemsa or Goodpasture

302
Q

NHP diseases

things to know about Macacine herpesvirus 4

A

AKA Rhesus lymphocryptovirus

gammaherpesvirus, lymphocryptovirus

natural host= ?

aberent host= Rhesus

coinfection with SIV leads to lymphoma or lesions resembling oral hairy leukoplakia

303
Q

mouse diseases

identify the two papovaviruses that infect mice

A

Polyomavirus and K virus (Kilham virus)

304
Q

what does (c) stand for in mouse nomenclature

A

recombinant congenic

305
Q

list mouse caging material from most durrable to least

A

polyethylene, polystyrene, polypropylene, polycarbonate, polyethermide

306
Q

pig diseases

Things to know about Porcine circovirus associated disease

A

Type 2

Post weaning multisystemic wasting syndrome, porcine dermatitis and nephropathy syndrome, porcine respiratory disease complex and occasionally repro failures

307
Q

NHP diseases

things to know about Bordatella bronchiseptica

A

commensal in nasopharynx

respiratory disease

308
Q

in what species is proteinuria normal

A

rats and dogs

309
Q

Pig diseases

Things to know about Pasteurellosis

A

severe suppurative bronchopneumonia

primary= septicemia in piglets

secondary= in conjunction with other diseases and stress

310
Q

mouse diseases

3 important things about Pasturella pneumotropica

A

1- subclinical opportunistic pathogen, if immunosuppressed will see clinial signs

2- suppurative inflammation and abscesses

3- ubiquitous inhabitant of skin, upper respiratory tract and GI

311
Q

rat diseases

what is the most common mite?

description?

A

Radfordia ensifera

two claws EQUAL length

312
Q

what does (;) stand for in mouse nomenclature

A

incipient congenic

313
Q

mouse diseases

8 important things about Salmonella

A
  1. serovars Typimurium and Enteritids
  2. Zoonotic
  3. nutritional iron deficiency has attenuating effect
  4. BL6, C3H are susceptible, AJ, CBA are intermediate, 129 are resistant
  5. 3 types of infection seen acute in young mice; subactue mice have distended abdomens with hepatomegally and splenomegally, chronic mice have weight loss and anorexia
  6. granulomatous lesions leading to septic thrombi
  7. enrich with Selenite F cystine broth before culture
  8. subclinical carriers and chronic carriers are seen when animals recover
314
Q

NHP diseases

CS seen with Sarcocystist kortei or nesbitti

A

monkey is intermediate host (get from eating raw monkey)

think white nodules in mesentery and serosa, no inflammatory reaction

315
Q

NHP diseases

things to know about Yersina

A

Y. enterocolitica and pseudotuberculosis

fulminating enteric and septicemic disease

NW and OW

Squirrel monkeys=cervical lymph nodes enlarged

will also see vomiting and severe abdominal pain

316
Q

pig biology

hormone to detect pregnancy

A

esterone sulfate, peak at 23-30 days gestation, produced by fetus

317
Q

rabbit diseases

things to know about alpha herpesvirus infection

A

leproid herpesvirus 4

from domestic rabbits

severe disease in preweanlings

318
Q

pig biology

which breeds are susceptible to malignant hyperthermia

A

Duroc, Yorkshire, Poland China, Landrace, Pietran

damn you poor little piggy

319
Q

NHP diseases

things to know about the measles virus

A

Paramyxoviridae, morbillivirus

Rhesus monkey is model for measles infection

Koplik’s spots

respiratory and derm signs, NW get GI

causes immunosuppression

320
Q

NHP diseases

things to know about Saimiriine herpesvirus 2

A

natural host= squirrel monkey

aberent host= other new worlds, owl monkeys

lymphoma, lymphocytic leukemia (model for Burketts lymphoma)

gammaherpesvirus, lymphocryptovirus

related to Epstein-Barr virus/infectious mononucleosis

321
Q

rabbit diseases

hepatic coccidiosis

A

Eimeria stiedae

younger, more cysts

multifocal yellowish white lesions of varying size and white streaks on liver

bile and gallbladder also

322
Q

NHP diseases

things to know about Rabies virus

A

rhabdoviridae, lyssavirus

vaccinate, attenuated vaccines are bad-can produce disease in NW

323
Q

rat diseases

3 things to know about M. pulmonis

A
  1. natural host for M. pulmonis
  2. persistent life long infection
  3. single most important historical infectious complication of research
324
Q

rabbit diseases

most common tumor in rabbits

A

uterine adenocarcinoma

325
Q

mouse diseases

5 important things about Mousepox virus

A

1) 3 forms of disease asymptomatic, chronic, acute lethal
2) liver, spleen and epithelial cell lesions with inclusions are pathognomonic
3) Marchal bodies (type A intracytoplasmic inclusions) acidiphilic well demarcated incusion bodies in epuithelial cells. Type B are basophilic and found in internal organs
4) DBA/1, DBA/2, BALB/c, A, C3H are most susceptible

C57BL6, AKR are most resistant

5) orthopox virus

326
Q

NHP diseases

things to know about Simian virus 40

A

polyomavirus

common latent infection but clinical disease associated with immunosuppression

brain, lung, kidney lesions,

327
Q

what hormone is responsible for secreation of androgens

328
Q

rat diseases

3 things about rat cytomegalovirus

A

Beta herpesvirus

low significance as no known natural infections

latency in salivary glands

329
Q

pig models

which breed is a model for melanoma

330
Q

conplastic

A

mitochondiral substitution

331
Q

mouse diseases

5 important things to know about mouse hepatitis virus

A

1) corona virus
2) 2 strains- enterotropic and neurotropic/respiratory/ multisystemic

infects suckling mice less than 2 wks of age

3) necrosis and syncytia of either intestinal villi or nasal mucosa or multiple organs
4) persistent infection of immunocompromised mice
5) SJL and A/J mice are resistant; BALB/c and DBA/2 are susceptible

332
Q

NHP diseases

things to know about Nochia nochi

A

stomach, pouches that look like cauliflower

nematode

333
Q

NHP diseases

things to know about Simian Hemorrhagic Fever Virus

A

arteriviridae

Patas, AG, and baboons are reservoir

Macaques fata bleeding syndrome

hemorrage and necrosis of proximal duodenum (not hepatic or adrenal)

334
Q

rat diseases

Which strain is most prone to mammary neoplasms?

A

Sprague Dawley

F344 and Wistar Han are second

335
Q

Animal models

Colonic adenocarcinoma,

ulcerative colitis/IBD

A

Sagunius oedipus

336
Q

NHP diseases

things to know about Simian Immunodeficiency virus

A

retrovirus, lentivirus

low pathogenicity in African, disease in Asian

zoonotic

persistent lymphadenopathy, tropism for CD4 T cells

337
Q

rule of thumb for salivary gland products

A

parotid= serous

submaxillary= mixed (serous in mice)

sublingual= mucous

338
Q

pig diseases

List the common respiratory diseases of swine

A

mycoplasmal pneumonia

atrophic rhinitis

pasteurellosis

inclusion body rhinitis

pleuropneumonia

Swine flu

pseudorabies (Aujeszky’s disease)

339
Q

NHP diseases

things to know about the Filoviruses

A

Ebola and Marburg

Marburg= from AG monkeys

adrenal and hepatic necrosis

340
Q

rabbit models

mutation seen in Watanabe Heritable Hyperlipidemic Rabbit

A

LDL receptor deficent

341
Q

Pig diseases

Important things to know about Streptococcus suis

A

5-16 wk old most susceptible (nursing or recently weaned pigs)

Meningitis, arthritis

zoonotic

fibrinous bronchitis, pleuritis, pericarditis

342
Q

rabbit biology

unique characteristics of reproductive tract

A

duplex uterus with separate cervices

inguinal pouches located lateral to genetilia in both sexes

inguinal canals are open in males

343
Q

NHP diseases

things to know about Colibacillosis

A

frequent normal fecal isolate but may or may not cause clinical disease

EPEC is common pathogen of SIV infected macaques

NW and OW

344
Q

what does (x) stand for in mouse nomenclature

A

recombinant inbred

345
Q

animal model

Legionnaires Disease

A

Cavia procellus

Callithrix jacchus

Chlorocebus aethiops

Macaca mulatta

346
Q

canine diseases

zoonotic disease associated with Toxascaris canis

A

visceral larval migrans and ocular larval migrans

347
Q

rabbit models

induction agent for acute acalculous cholecystits

A

lysophosphatidylcholine

348
Q

pig biology

describe the important facets of pig coronary anatomy

A

right sided dominant and no pre-existing collateral circulation

349
Q

NHP biology

tamarins are more susceptible to which diseases and why?

A

viral

limited MHC class I

350
Q

mouse diseases

4 important things about Corynebacterium

A
  1. pseudotuberculosis- liquifactive caseous material
  2. bovis- orthokeratotic hyperkeratosis, scaly skin
  3. “chinese letters”
  4. differential for low humidity.
351
Q

pig diseases

Things to know about greasy pig disease

A

Staph hyicus

5days-2mo

no pruritis

352
Q

mouse diseases

identify the two adenoviruses of mice

A

MAdV-1 and 2 or A and B

353
Q

mouse diseases

What is the principal intermediate host for Toxoplasma gondii? The definitive host?

354
Q

Animal models

Diabetes mellitus

A

Macaca nigra

355
Q

mouse diseases

2 important things about Radfordia affinis

A

1- causes little to no inflammatory reaction

2- two empodial claws of unequal length

356
Q

mouse diseases

4 important things about Theilers murine encephalomyelitis virus

A

1) mouse polio virus, Cardiovirus
2) experimentally induced neurologic disease, demyelinating phase, paralysis, some recovery
3) replicates in intestinal mucosa
4) SJL, DBA/2, C3H are susceptable; BALB/c, B6, 129 are resistant

357
Q

Animal models

chronic destructive periodontitis

A

Oryzomys palustris- rice rat

Callithrix jacchus- common marmoset

358
Q

Saimiri are animal models for:

A

pharmacology/toxicology

neuroscience

CJD

malaria

labor and pelvic organ prolapse

359
Q

Canine diseases

which protozoal diseases are associated with immunosuppression

360
Q

Which mouse strains are resistant to amyloidosis?

A

C57BL, BALB/c and C3H

361
Q

strain specific lesions for C3H

A

dystrophic cardicac calcinosis

hamartomas

mammary tumors

362
Q

pig diseases

importatnt things to know about Pseudorabies

A

Aujeszky’s disease

herpes virus

latent in sensory ganglia

high mortality in pigs under 9 weeks of age

reportable disease

363
Q

rat diseases

the rat louse has what name and is the vector for what hemoplasma

A

Polyplax spinulosa

Mycoplasma haemomuris

364
Q

NHP diseases

things to know about Dengue Hemorrhagic Fever

A

flavivirus

macaques are asymptomatic

mosquito transmits

zoonotoic

365
Q

pig diseases

Things to know about Proliferative Ileitis/enteritis

A

caused by Lawsonia intracellularis

pigs 6-20 wks infected

hyperplasia of crypt enterocytes

wide host range

silver stain

366
Q

NHP diseases

things to know about Anatrichosoma spp

A

think white lines on hands and feet

nematode

367
Q

rabbit model

heratibility of the WHHL model?

A

autosomal dominant

368
Q

rat diseases

What anesthetic agent is known to cause adynamic illeus

A

Cloral hydrate

369
Q

NHP diseases

most common nematode in OW and great apes

A

Oseophagostomum

370
Q

NHP models

Pan troglodytes

A

AIDS

HEP B,C

cognition and language development

371
Q

describe the difference between male and female mouse kidneys

A

cuboidal epithelium lining Bowman’s capsule in males, squamous epithelium in females

372
Q

Aotus are animal models for:

A

malaria

cutaneous and visceral leishmaniasis

viral hepatitis A

vision

373
Q

rabbit biology

what is unique about the alkaline phosphatase of rabbits

A

they have three isoforms (liver , intestinal and kidney. other mammals have 2 intensinal and liver/kidney/rest)

374
Q

NHP diseases

things to know about Pneumocystis

A

species specific

ubiquitous in the environment

associated with SIV or other immunodeficiency

375
Q

pig diseases

things to know about Salmonellolsis

A

S. choleraesuis, typhimurium, typhisuis

3wks-5m old

respiratory, enteric, and repro systems

376
Q

rat diseases

describe the clincial syndromes seen with sialodacryoadenitis virus

A

corona virus

breeding colonies, mature rats are immune, clinical disease is associated with preweanling animals enzootic

in epizootic, post weanling to adult rats are exposed and develop cervical swelling due to infallmmation and edema of submaxillary glands

in immunodeficient rats, see persistent infection

377
Q

rabbit diseases

Treponematosis

A

Treponema paraluiscunniculi (similar to T. pallidum)

rabbit syphylis

spirochetes with Warthin starry silver stain

tests: RPR rapid plasma reagin card test or veneral disease research laboratory slide test

378
Q

rat biology

transfer of antibodies from mom to pup occurs when?

A

in utero via the yolk sac

intestinal absorption of colostrum for up to 16 days postpartum

379
Q

NHP disease

name the sucking louse found in NHP

380
Q

rat biology

hearing range of rat

A

500Hz to 60-80kHz

381
Q

rat model

Zucker rat is a model for

383
Q

rat model

SHR (spontaneous hypertensive rat) is a model for

A

hypertension

cardiovascular research

384
Q

what does : stand for in mouse nomenclature

385
Q

rabbit diseases

things to know about rabbit (shope) fibroma virus

A

fibramatosis endemic in wild rabbits

spread by arthropods

fibromas are flat, subcutaneous, eaisly moveable tumors

386
Q

rat diseases

3 things to know about Streptobacillus moniliformis

A
  1. causative agent of rat bite fever
  2. commensal of nasopharynx of wild rats
  3. does not cause disease in rats
387
Q

Mouse diseases

7 important things about Mycoplasmosis

A

1- chattering

2- rats are reservoir for mice

3- C57BL6 resistant; BALB/c, C3H, DBA/2 are susceptible

4- treatment only suppresses disease

5- T cell response exacerbate clinical signs

6- cobble stone appearance of lungs

7- nude/SCID mice develop systemic disease

388
Q

rat diseases

What rat strains have a high prevalence of hydronephrosis?

A

Brown Norway

Gunn

Zucker

389
Q

rabbit diseases

things to know about coronavirus

A

pleural effusion disease

congestive heart failure

390
Q

NHP diseases

which pentastomes are found in OW

A

armillifer and porocephalus

391
Q

NHP diseases

Simian Retrovirus (SRV)

A

retrovirus, betaretrovirus, type D

zoonotic

CS= generalized lymphadenopathy, retroperitoneal fibromatosis when infected with gamma herpesvirus

broad immune cell tropism

392
Q

animal models

cutaneous leishmania

A

Aotus

Saguinus

393
Q

mouse diseases

name the two paramyxoviruses that infect mice

A

Sendai

Murine pneumonia virus

394
Q

animal models

Crohn’s disease

A

terminal ileitis in Saguinus mystax and labiatus

395
Q

rabbit models

difference between WHHL and St Thomas rabbits

A

St Thomas have normal LDL receptors

396
Q

pig diseases

List the common enteric diseases

A

swine dysentery

proliferative Ileitis

Colibacillosis

Clostridial enteritis

transmissible gastroenteritis

rotaviral enteritis

397
Q

rat diseases

Which rat strain is most susceptible to Alveolar histiocytosis?

A

F344 and Sprague Dawley

398
Q

mouse diseases

4 important things to know about Group A rotaviruses (murine rotavirus)

A

EDIM

high morbidity, low mortality

affects mice less than 2 wks of age

terminally differentiated enterocytes, vacuolation at the tips

ACLAM study sets (22 decks)

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