A &A (BBCH24 and A&ABB) Flashcards
1
Q
what is the recommended acclimation period for rodents?
A
24-72hrs
2
Q
what class of anesthetic are ketamine and tiletamine in?
A
dissociative
3
Q
effects produced by ketamine
A
a degree of analgesia and immobility without muscle relaxation, adequate for restraint but not for anesthesia
4
Q
what class of anesthetic are barbituates (sodium pentobarbital) in?
A
sedative hypnotics
5
Q
effects produced by barbiturates?
A
minimal analgesic effect, affect consciousness, dose related respiratory and cardiovascular depression, decreased cerebral blood flow and intracranial pressure
6
Q
mechanism and classification of Inactin
A
barbituate, sedative hypnotic
7
Q
uses of Inactin
A
long duration of anesthesia, 3hrs or more in the rat
8
Q
considerations for Propofol
A
1) alkylphenol derivative 2) respiratory and cardiovascular depression 3) resembles thiopental 4) rapid recovery
9
Q
another name for Avertin
A
Tribromoethanol
10
Q
considerations for the use of Avertin
A
short surgical procedures give IP but degradation products are irritants and toxic so may be recommended for terminal procedures only but has been used in transgenic mouse production narrow safety margin- respiratory and circulatory depression, generally unpredictable
11
Q
describe neuroleptics
A
combination of potent opioids and butyrophenone tranquilizers
12
Q
effects of alpha-chloralose
A
minimal analgesia, not recommended for painful manipulations, used in studies of long duration while preserving autonomic reflexes, not suitable for survival procedures due to rough induction, prolonged recovery and seizures
13
Q
uses for chloral hydrate
A
sedative hypnotic, medium duration light anesthesia with minimal effects on cardiovascular function or reflexes, associated with peritonitis and adynamic ileus, carcinogenic
14
Q
properties of urethane
A
(aka ethyl carbamate) greater analgesia, prolonged stable anesthesia in rats, liver and pulmonary damage and carcinogenic, not suitable for recovery anesthesia
15
Q
effects of metomidate and etomidate
A
rapid loss of consciousness, minimal analgesia, good cardiovascular stability, bad in that it suppresses the adrenocortical function of some species
16
Q
sevoflurane+rats+soda lime= ?
A
compound A- nephrotoxic
17
Q
receptor for Buprenorphine?
A
partial mu agonist
18
Q
example of alpha2 agonists
A
xylazine, dexmedetomidine
19
Q
side effects of alpha2 agonists
A
hyperglycemia, bradycardia, vasoconstriction, hypothermia
20
Q
side effects of additional dosing of alpha2 agonists
A
bradycardia and cardiac arrest
21
Q
reversal for alpha2 agonists
A
atipamezole
22
Q
examples of benzodiazepines
A
diazepam and midazolam
23
Q
effects of benzodiazepines
A
anxiolysis, sedation, and muscle relaxation, not analgesic
24
Q
reversal of benzodiazepines
A
flumazenil
25
what form of post op care has been shown to significantly increase rates of pregnancy and fetal implantation?
supplemental heat overnight
26
what are the considerations of anesthetics for mouse fetal surgery and why?
isoflurane causes uterine relaxation alpha2 agonists reduce uterine blood flow and increase uterine contractility
27
effects of isoflurane anesthesia
1) cardio and neuro protective 2) little to no GI and liver 3) mixed on the lungs (can cause cilliary disfunction) 4) leukopenia, neutropenia, thrombocytopenia in C3H/HeN mice 5) hypogylcemia and metabolic acidosis in neonatal mice
28
effects of halothane anesthesia
1) most extensive effects on cardiopulmonary system 2) potent bronchodilator 3) neuroprotective 4) sustained elevation in cortisterone for up to 24 hours
29
effects of sevoflurane anesthesia
1) cardioprotective and neuroprotective (brain not spinal cord) 2) does not affect tracheal epilethial cell cilliary function 3) nephrotoxic for rats (compound A)
30
effects of desflurane anesthesia
1) quick recovery 2) neuroprotective 3) cardioprotective (even during and after infarct, potential treatment)
31
effects of methoxyflurane
1) low concentration at room temp, most often used in a bell jar set up 2) profound effect on hormone release (HPA axis, ACTH and corticosterone release)
32
effects of enflurane
1) lower margin of safety, apenic index is lower than MAC 2) epileptogenic
33
which anesthetic is thought to be responsible for causing ocular lesions in rats
ketamine/ xylazine
34
physiologic effects of ketamine/diazepam in rodents
minimal cardiovascular and respiratory effects poor muscle relaxation
35
physiologic effects of pentobarbital in rodents
significant cardiovascular depression in mice hypotension and uncompensated respiratory acidosis in rats
36
effects of Thiopental in rodents
ultrashort acting barbiturate induction agent administered IV irritant, not advisable for survival procedures
37
physiologic effects of Telazol in rodents
very narrow safety margin
38
mechanism of action of phenothiazine tranquilizers
reduce the animals reaction to handling or pain via sedation and CNS depression, no analgesia, additive positive effect with other anesthetics
39
effects of morphine in hamsters
analgesia without CNS or respiratory depression
40
effects of morphine on intracranial pressure
increases ICP
41
which NSAIDS do not work via the COX 1 or 2 pathway?
Acetaminophen and dipyrone
42
what is the most safe anesthetic choice for neonatal rodents?
inhalents
43
what is the second most safe anesthetic choice for neonatal rodents?
hypothermia can be used in altricial rodents up to 7 days of age
44
side effect of telazol in rabbits?
nephrotoxicity
45
what are the traditional reflexes used to monitor anesthetic depth in rabbits
righting palpebral corneal pedal withdrawl pinna
46
which reflex is the most accurate measure of depth of anesthesia in rabbits
pinna, pedal withdrawl, corneal, palpebral
47
what is the recommended fasting for rabbits weighing under 3kg?
not more than 12 hours
48
what are some signs of the hypnotzed state in rabbits?
miosis analgesia increased depth of respiration reduced respiratory rate, heart rate, and BP
49
importance of NSAIDS in ferrets
deficient in the glucoronidation pathway, may manifest signs of toxicity
50
up to what age can hypothermia be used to induce anestheisa in neonatal ferrets
5 days old
51
which inhalent anesthetic has been implicated in causing malignant hyperthermia
halothane
52
what cardiovascular defects are swine known to be predisposed to?
ventral septal defect patent foramen ovale
53
cardiovascular effects of telazol and xylazine in pigs
cardiopressive in swine
54
cardiovascular effects of ketamine/medetomidine and ketamine/midazolam in swine
protect against arrhythmias and provide stable hemodynamics in swine
55
respiratory effects of barbiturates in swine
potent respiratory depressant in swine
56
concerns about anticholinergics in small ruminants?
do not consistently reduce salivary secreations except at high doses and only reduces the aqueous portion-making them thicker, short duration of action
57
concerns about xylazine in ruminants
10-20 times more potent. goats\>cattle\>sheep
58
concerns with diazepam in small ruminants?
absorbed poorly following IM injection
59
describe how to perform a posterior epidural block in ruminants and when it would be used?
site of injection is the sacrococcygeal or first intercoccygeal space. used to provide anesthesia to the perineum or tail of standing cattle
60
describe how to perform an anterior epidural block in ruminants and when it would be used?
lumbosacral space. provides anesthesia to the caudal abdomen and useful for abdominal procedures, effects the motor and sensory block of the pelvic limbs so the animal is unable to stand
61
name the two ways to perform a paravertebral block
proximal block and distal block
62
describe how to perform a proximal paravertebral block
needle is inserted vertically about 5 cm lateral to the dorsal spinus process until it strikes bone, then walked off the rim and inject into the intertransverse ligament
63
describe how to perform a distal paravertebral block
injection is started at the tip of the transverse process and deposited as the needle is advanced toward the spine
64
list three anatomic considerations in regards to anesthesia in swine
1) highly susceptible to ventricular arrhythmias 2) fragile pulmonary tissue which may be damaged by over-inflation with mechanical respirators, 3) left hemizygous vein which drains the intercostal vessels into the coronary sinus
65
describe the unique receptors for breathing regulation found in birds
intrapulmonary chemoreceptors that are inhibited by high lung PCO2 excited by low lung PCO2 and provide phasic feedback for the control of the rate and depth of breathing
66
effects of diazepam in birds
excellent muscle relaxant duration of action is short and recovery is NOT prolonged
67
effects of xylazine in birds
profound cardiopulmonary effects including second degree heart block, bradyarrhythmias
68
describe the opioid receptors found in birds
they have greater presence of kappa receptor, located in the forebrain, therefore butorphanol provides effective analgesia over morphine
69
give some examples of thermal acute pain models
tail flick
tail withdrawl
hot plate
paw withdrawl
70
give some examples of mechanical acute pain models
tail-clip
von Frey Filament
71
give some examples of chemical acute pain models
formalin
abdominal constriction
72
what are some advantages of the tail flick acute pain assay
speed and ease of use
73
what are some disadvantages of disadvantages of the tail flick assay
low clinical relevance
74
what are some advantages of the tail withdrawl assay
no effect of repeated assay
75
what are some disadvantages of the tail withdrawl assay
requires restraint
76
what are some advantages of the hot plate assay
speed and ease of use no restraint required
77
what are some disadvantages of the hot plate assay
complex behaviors repeated testing effects
78
what are some advantages of the paw withdrawl assay
no restraint required can test contralateral hindpaw (allows for independent testing of both sides of the body) no effect of repeated testing
79
what are some disadvantages of the paw withdrawl assay
low clinical relevance long habituation time
80
what are some advantages of the von Frey filament assay
used in humans
81
what are some disadvantages of the von Frey filament assay
long habituation time hard to standardize across labs
82
what are some examples of common chronic pain assays
complete freunds adjuvant
chronic constriction injury
partial sciatic nerve ligation
spinal nerve ligation
spared nerve injury
Vincristine,
paclitaxel
83
define hyperalgesia
increased response to noxious stimuli
84
define allodynia
response to normally non-noxious stimuli
85
what is the most common chemical used for abdominal constriction test
glacial acetic acid
86
what does IASP stand for?
international association for the study of pain
87
mechanism of action of barbiturates and propofol?
decrease the rate of dissociation of GABA from its receptor
88
mechanism of action of benzodiazepines?
enhance the affinity of the receptors for GABA
89
how are barbiturates metabolized?
by the cytochrome P450 pathway in liver, thus tolerance may be seen with repeated dosing
90
another name for Inactin
thiobutabarbital, no longer available in pharmaceutical grade
91
immune system effects of thiopental
inhibits cell mediated immunity, strong anti-inflammatory effect
92
in which species is propofol the least effective?
rabbits
93
what anesthetic agent is considered ineffective in rabbits and results in both short periods of anesthesia and death?
thiobutabarbital
94
anesthetic class of Alphaxalone
steroid anesthetic
95
physiologic effects of alphaxalone
rapid induction of short term anesthesia
rapid recovery
wide safety margin
minimal accumulation with repeated dose
Cremophor resulted in histamine release and its removal from the market
96
effects of benzodiazepines
marked sedation, anxiolytic, spinal cord mediated muscle relaxant, awareness persists, not analgesic, minimal cardiovascular and mild respiratory effects
97
mechanism of action for Ketamine
NMDA antagonist, binds to a receptor in the NMDA channel and prevents further ion flux, thus inhibiting glutamate action of the channel in a noncompetitive manner
98
what anesthetic agent are swine resistant to?
xylazine and all other alpha 2 agonists
99
what reversal agent is known to increase sexual activity in rats and monkeys?
atipamezole, other side effects are increases pain-related responses by blocking noradrenergic feedback inhibition of pain. beneficial effects on alertness , selective attention, planning, learning and recall
100
what is the proposed mechanism of action of inhalation anesthetics
enhancement of the inhibitory neurotransmitter GABA
101
where are the Mu opioid receptors located
cerebral cortex, thalamus, periaqueductal gray
102
where are the delta opioid receptors located
frontal cortex limbic system, olfactory tubercule
103
where are the kappa opioid receptors located
spinal cord
104
mechanism of action of Pentazocine
partial agonist of mu receptor(may be weak antagonist) and powerful k receptor agonist
105
mechanism of action of buprenorphine
partial mu agonist and k antagonist
106
mechanism of action of butorphanol
mu antagonist, k agonist
107
what is the differentiating feature of an A circuit?
fresh gas comes in at end of circuit instead of near ET tube connection
108
what is the differentiating feature of a D circuit?
rebreating bag is at the end of circuit, exhaust and pop off valve just before bag
109
what is the differentiating feature of an E circuit?
no rebreating bag
110
what is the differentiating feature of an F circuit?
exhaust and pop off are through the rebreathing bag
111
what is another name for the D circut?
a Baine system
112
name the blade
Phillips
113
name the blade
Robertshaw
114
name the blade
modified miller
115
name the blade
wisconsin
116
name the blade
macintosh
117
name the blade
Choi double-angle blade
118
What are the NIOSH recomendations for halogenated anesthetic gasses?
should not exceed 2ppm ceiling concentrations over a period of no greater than 1 hour
119
what is the usual method of obtaining time weighted average sampling of halogenated anesthetic gasses?
active or passive dosimetry
120
how often does OSHA recommend air monitoring be conducted for waste anesthetic gasses?
every 6 months
121
how long should permanent medical records of employees be kept?
duration of employment + 20 years
122
what injectable anesthetics have an effect at the GABA receptor?
barbiturates
chloral hydrate
alpha-chloralose
tribromoethanol
propofol, metomidate, etomidate
benzodiazepines
