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ACLAM study sets > NW and OW NHP models > Flashcards

NW and OW NHP models Flashcards

1
Q

Callithrix spp are used for

A

Parkinson’s disease

Multiple sclerosis

hemochromatosis

infectious diseases (hepatitis, EBV, malaria)

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2
Q

Saguinus spp used for

A

viral hepatitis

colonic adenocarcinoma

inflammatory bowel disease

viral oncology

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3
Q

Saimiri spp used for

A

pharmacology/toxicology

infectious disease( malaria, CJD, spong encephala)

labor and pelvic organ prolapse

stress, aging

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4
Q

Cebus spp used for

A

pharmacology/toxicology

viral oncogenesis

purine metabolism

atherosclerosis

nutrition

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5
Q

Aotus spp used for

A

infectious diease (malaria, leishmaniasis, viral oncogeneic viruses, viral hepatitis A) glomerulonephritis

atherosclerosis

immunology

vision

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6
Q

Lagothrix spp used for

A

(Woolly monkey)

hypertension

cardiovascular research

hepatitis B virus

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7
Q

animal model for dental carries

A

all NHP

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8
Q

creation of induced model for dental carries

A

experimentally induced with Strep mutans combined with daily meals rich in sugar

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9
Q

animal model for chronic destructive periodontitis

A

Callithrix jacchus

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10
Q

creation of induced model for chronic destructive periodontitis

A

induce experimentally by placement of peri-dental silk ligatures or orthodontic elastics as well as surgical removal of alveolar bone

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11
Q

animal model for Bacillary Dysentery/Shigellosis

A

most NHP, gorillas seem to be very susceptible

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12
Q

species of Shigellosis responsible for dysetery

A

S. flexneri, boydii, sonnei

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13
Q

clinical signs of Bacillary Dysentery

A

edematous face, liquid stools with mucus and blood. Clinical features and gross microscopic lesions of the colon of the monkey infected with shigellae are indistinguishable from human shigellosis. colonic changes are similar to those in man

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14
Q

animal model for Helicobacter gastritis

A

Old and New World Primates

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15
Q

purpose of model for Colibacillosis

A

evaluation of a prototype enterotoxigenic E. coli subunit vaccine

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16
Q

animal model for Enteropathogenic Colibacillosis

A

Pan tryglodytes, Pongo pygmaeus

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17
Q

characteristics of Enteropathogenic Colibacillosis

A

clinical and pathological features are similar to those in human infants. Same E. coli serotypes are found. studied in anthropoid apes, under 2 years of age.

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18
Q

animal model for Campylobacteriosis

A

Aotus nancymae, clinical course similar to that observed in humans

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19
Q

animal model for Cryptosporidosis

A

Macaca nemestrina

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20
Q

creation of induced Cryptosporidiosis model

A

inoculation of oocysts via nasogastric tube results in clinical enteritis and fecal passage of large numbers of cryptosporidial oocysts. partial acquired immunity has been demonstrated

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21
Q

animal model for Helicobacter gastritis

A

old and new world NHPs

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22
Q

characteristics of Helicobacter gastritis model

A

NHPs commonly have subclinical infections but with histologic evidence of chronic gastritis and are often co-infected with H. pylori. Rhesus have been used to induce H. pylori gastritis and for therapeutic vaccine trials

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23
Q

animal model for colonic adenocarcinoma

A

Saguinus oedipus

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24
Q

characteristics of model for colonic adenocarcinoma

A

spontaneously occurring primary adenocarcinoma of cecum, colon, and rectum, related to marmoset wasting disease

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25
Q

animal model for ulcerative colitis

A

Saguinus oedipus

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26
Q

model for ulcerative colitis

A

spontaneous, associated with decreased fecal short-chain fatty acid levels, progressive inflammation in a pattern similar to human colitis

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27
Q

purpose of model for ulcerative colitis

A

assess new treatments of inflammatory bowel disease

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28
Q

animal model of colitis cystica profunda

A

Saguinus mystax and S. labiatus, spontaneous

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29
Q

human disease of cystica profunda

A

characterized by mucus-filled cysts in the colonic and cecal mucosa, submucosa and muscularis propria, frequently lined by demonstrable epithelium, etiology unknown

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30
Q

animal model for Chron’s disease

A

Saguinus mystax and S. labiatus

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31
Q

chracteristics of model for Chron’s disease

A

spontaneous terminal ileitis resembling Chron’s disease in humans has been reported. etiology unknown, primary lesion is ulceration and thickening of the terminal portion of the ileum

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32
Q

animal model for Atherosclerosis

A

Cebus spp, Saimiri sciureus, addition of cholesterol to the diet results in hypercholesterolemia and exacerbation of atherosclerosis

Macaca mulatta, fascicularis, Chlorocebus aethiops, Papio spp

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33
Q

characteristics of spontaneous model for atherosclerosis

A

can study plaque regression and atherogenesis studies, and also effects of multiple risk factors suck as diet, stress, hormones, pharmacologic agents, and psychosocial factors

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34
Q

animal model for hypertension

A

Aotus nancymae, Lagothrix lagotricha

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35
Q

characteristics of model for hypertension

A

spontaneous, neural based, hyperactive responses of the sympathetic nervous system

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36
Q

animal model for infantile strabisus

A

Saimiri spp

Macaca nemestrina, fascicularis,

Papio cynocephalus

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37
Q

characteristics of model for strabismus

A

esotropia in newborm monkeys by surgical tenotomy of both lateral rectus muscles

or injection of Botulinum A neurotoxin (reversible, can study recovery)

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38
Q

animal model for retinal ganglion cell morphology

A

Callithrix jacchus

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39
Q

characteristics of model for retinal ganglion cell morphology

A

good visual acuity and its retinal and subcortical pathways are very similar to humans

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40
Q

animal model for retinal degeneration

A

Saimiri spp

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41
Q

characteristics of model of retinal degeneration

A

spontaneous retinal degeneration similar to human degenerative disorder

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42
Q

animal model for retinal detachment

A

Aotus spp

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43
Q

characteristics of model for retinal detachment

A

correlations of naturally occurring detachments with long-term retinal detachment in owl monkeys

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44
Q

animal model for myopia

A

Callithrix jaccus

Macaca mulatta, arctoides (cats, tree shrews, marmosets, guinea pigs, and chickens)

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45
Q

characteristics of model for myopia

A

induced in infant animals, eyelids are surgically fused at birth and kept closed for one year

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46
Q

animal model for motion sickness

A

Saimiri spp

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47
Q

characteristics of model for motion sickness

A

induces by vertical oscillation and horizontal rotation, squirrel monkeys will vomit and are more active during test than most other NHPs

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48
Q

uses of model of motion sickenss

A

testing anit-motion sickness preparations

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49
Q

animal model of lymphocytic thyroiditis

A

Callithrix jacchus

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50
Q

characteristic of model of lymphocytic thyroiditis

A

chronic lymphyocytic auto-immune thyroiditis in conjunction with circulating antibodies to thyroid antigen, marmoset lesions are comparable to humans, marmosets show same sex predilection as seen in humans

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51
Q

animal model for stress

A

Saimiri, Callithrix

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52
Q

characteristics of model for stress

A

total circulating cortisol is 10 times greater than in humans, thought to be due to the disruptive presence of immature offspring that produces a chronic cortisol increase in captive adult squirrel monkeys

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53
Q

animal model for erythroblastosis fetalis

A

marmosets Callithrix spp

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54
Q

animal model for IgE studies

A

Callithrix jacchus

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55
Q

characteristics of erythroblastosis fetalis

A

similar fetoplacental situation, knowledge of blood groups

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56
Q

animal model for toxoplasmosis

A

Lagothrix lagothricha, Aotus lemurinus

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57
Q

characteristics of toxoplasmosis in NHP model

A

acute spontaneous, more frequent in NW than OW, a single case report in a male woolly monkey, source eating raw meat

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58
Q

animal model of malaria

A

Aotus spp, Saimri spp

Chipmanzee, Macaca mulatta

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59
Q

species of Malaria causing disease in man

A

Plasmodia falciparum, malariae, vivax, ovale

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60
Q

characteristics of malaria model

A

Aotus are susceptible to P. vivax, malaria is host specific, , S boliviensis are susceptible to infection with P. falciparum and different strains of P. vivax

Chimpanzees are the only known host for P. ovale

M.mulatta can be infected with a virulent strain of P. knowlesi

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61
Q

what species does the world health organization recommend as a model for evaluation of malaria vaccine candidates

A

Aotus nancymae

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62
Q

animal model for Haemobartonellosis

A

Saimri spp

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63
Q

characteristics of model for Haemobartonellosis

A

patent infection occurs following splenectomy, carriers commin in colony reared squirrel monkeys. reason for treating splenectomized squirrel monkeys with oxytetracycine before use in malaria studies.

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64
Q

animal model for Chaga’s Disease

A

Cebus paella, chronic chagasic cardiomyopathy

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65
Q

characteristics for model of Chaga’s Disease

A

cardiac lesions, focal or multifocal mononuclear infiltrates and/or isolated fibrosis

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66
Q

animal model for Cutaneous and Visceral Leishmaniasis

A

Aotus spp, Saguinus geoffroyi

visceral leshmaniasis- Chlorocebus aethiops

(hamsters are original animal model)

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67
Q

characteristics of model for Leishmaniasis

A

NHP develop self-limiting skin lesions with L. braxiliensis complex and severe to fatal visceral disease with L. donovani. transmitted by sandflies

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68
Q

animal model for Lymphocytic Choriomeningitis Virus Infection

A

Cebus albifrons

also: Macaca mulatta and fascicularis

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69
Q

characteristics of LCMV model

A

most common syndrome is meningitis nearly all LCM patients recover

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70
Q

animal model for yellow fever

A

Marmosets, tamarins, owl, spider, and squirrel monkeys, rhesus

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71
Q

characteristics of model of yellow fever

A

pathological species seen in NHP is similar to those in man

M. mulatta= disease resembles hyperacute form seen in man

NW are all extremely susceptible, except Cebus which are usually asymptomatic and Ateles are resistant

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72
Q

animal model for Dengue fever

A

Aotus nancymae

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73
Q

characteristics of Dengue fever model

A

Aotus develops viremia but no Dengue fever, or Dengue shock syndrome like humans

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74
Q

animal model of Eastern Equine Encephalitis

A

Aotus nancymae

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75
Q

characteristics of EEE model

A

A. nancymae sustains short term viremia and produces IgM and IgG post EEEV infection but no clinical disease, non-lethal model for evaluation of candidate vaccines against EEEV

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76
Q

animal model of Argentinian Hemorrhagic Fever

A

Callithrix jacchus

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77
Q

characteristics of Argentinian Hemorrhagic Fever

A

experimentally induced disease is quite similar to the natural infection of man

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78
Q

animal model of measles

A

Saimiri sciureus, Saguinus mystax

Masaca fascicularis

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79
Q

characteristics of model of measles

A

severe disease when introduced to captive NW monkey, typically see GI effects such as necrotizing colitis

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80
Q

animal model for human T-cell Lymphotropic virus (non-hodgkin’s lymphoma)

A

squirrel monkeys

Papio sp

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81
Q

characteristics of HTLV

A

chronically infected monkeys developed high titers of antibodies against structural proteins of the virus, as do HTLV humans, squirrel monkeys may be useful to study the pathogenesis of HTLV and for evaluating new candidate vaccines

HTLV is similar to STLV-1

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82
Q

animal model for Epstein-Barr Virus

A

Callithrix jacchus

Macaca mulatta

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83
Q

characteristics of EBV model

A

the B95-9 strain of EBV induces malignant lymphomas in cotton top tamarins, used to evaluate EBV vaccines

in Macaques develop key aspects of human infection

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84
Q

animal model fro Klebsiella pneumonia

A

SQuirrel monkey, marmosets

85
Q

characteristics for Klebsiella

A

lobar pneumonia develops after administration of only 700 organisms

86
Q

animal model for Helicobacter pylori infection

A

Saimiri spp

87
Q

characteristics of Helicobacter infection model

A

experimentally induced infection in Saimiri, used in immunogenicity and safety studies

88
Q

which hepatitis viruses are enterically transmitted?

89
Q

which hepatitis viruses are parenterally transmitted?

A

B,C, delta

90
Q

which hepatitis viruses produce disease in both OW and NW primates

91
Q

which viruses induce hepatitis in only a few OW species

A

B,C, delta

92
Q

which NHP species are susceptible to both Hep A and B

A

marmosets and chimpanzees

93
Q

which NHP species are most susceptible to Hep E

A

cynos and Aotus monkeys

94
Q

what is the animal model for Hep A

A

Aotus spp, Marmosets and Tamarins

95
Q

model of choice for Hep A research

96
Q

model of choice for Hep B research

A

Chimpanzee

97
Q

model of choice for Hep E research

A

Aotus monkey

98
Q

closest viral relative to Hep C that can be used as a model?

A

GBV-B, causes acute hepatitis, increased liver enzymes that quickly return to normal as virus is cleared

99
Q

animal model for GBV-B as model for Hep C research

A

Saguinus spp, Callithrix jaccus

100
Q

animal model for Cholelithiasis

A

Aotus spp, Callithrix jacchus, Saimiri spp

101
Q

characteristics of Cholelithiasis

A

Aotus and Callithrix, not based on cholesterol in the diet, Squirrel monkey requires addition of cholesterol to the diet. The frequency of stone formation appears to be inversely related to the concentration of cholesterol in the plasma. There is a suggestion that regimens which lower plasma cholesterol may result in accelerated gallstone formation.

102
Q

animal model of cholesterol cholelithiasis

103
Q

characteristics of cholesterol cholelithiasis

A

Aotus monkeys spontaneously develop cholesterol gallstones when fed a diet supplemented with 1.5% cholesterol.

104
Q

NHP animal model for Gilbert’s syndrome

A

Saimiri boliviensis

105
Q

characteristics of model for Gilbert’s syndrome

A

nonhemolytic unconjugated hyperbilirubinemia, defect in hepatic uptake of unconjugated bilirubin and/or a conjugating enzyme deficiency, plasma of normal Bolivian squirrel monkeys what are fasted for 24hrs have a hyperbilirubinemia. most likely due to the presence of the hepatic enzyme UDP-glucuronyl transferase that results in a higher plasma and hepatic bilirubin level during a fast.

106
Q

animal model of hemochromatosis

A

Callithrix jacchus

107
Q

characteristics of model of hemochromatosis

A

characterized by excessive absorption of ingested iron, saturation of iron-binding protein, and deposition of hemosiderin in tissues especially liver, pancreas, and skin. will seek Kupffer cells in the liver lining sinusoids eating all the hemosiderin

108
Q

animal model of gout

A

Cebus, Ateles, Lagothrix, Saguinus spp

109
Q

characteristics of model of gout

A

NHP and humans lack uricase leading to hyperuricemia with subsequent deposition of urates in and about the joints.

110
Q

animal model of Parkinson’s Disease

A

Callithrix jacchus

Macaca mulatta

Macaca nemestrina

Chlorocebus aethiops

111
Q

characteristics of Parkinson’s model

A

acute exposure to MPTP causes motor symptoms/signs indistinguishable from PD. Lewy bodys are the characteristic intracellular inclusion seen in the brain. MPTP induces and acute, toxic disorder associated with injury to nigral neurons, whereas PD is a chronically progressive disorder of unknown cause. Experimental animals do not develop the cognitive and memory impairments that occur in PD

112
Q

animal model for Cerebral Beta-Amyloid Angiopathy

A

Saimiri spp

113
Q

characteristics of Cerebral Beta-Amyloid Angiopathy

A

manifest beta-amyloid deposition in the cerebral blood vessels with age. used to test in vivo beta-amyloid labeling strategies

114
Q

animal model for Multiple Sclerosis/ Experimental Allergic Encephalomyelitis

A

Callithrix jacchus

Macaca mulatta

Macaca fascicularis

115
Q

characteristics of Multiple Sclerosis model

A

called experimental allergic or autoimmune encephalomyelitis. sensitization to myelin basic protein (BP) induces a cell-mediated delyated-type hypersensitivity reaction to host myelin

116
Q

how do you causes relapsing remitting EAE

A

treat acute attack with dexamethasone for 3 days

117
Q

animal model for Spongiform Encephalopathy

A

Saimiri spp, Saguinus spp

118
Q

characteristics of Spongiform encephalopathy model

A

mental and physical abilities deterioriate and a myrial of tiny holes appear in the cortex, causing it to appear like a sponge.

119
Q

animal model of neurodegenerative disease

A

aged Saimiri spp

120
Q

characteristics of neurodegenerative disease model

A

aged NHP develop age associated behavioral and brain abnormalities similar to those in aged humans such as degenerative changes, neuritis and deposits of amyloid in senile plaques and around blood vessels

121
Q

animal model for Lissencephaly

A

Saimiri spp

122
Q

characteristics of Lissencephaly model

A

Saimiri is highest species of primate with a lissencephalic brain, used to study cortical spreading depression in a highly encephalized brain

123
Q

animal model for Viral Encephalitis and epilepsy

A

intracerebral injection with canine distemper virus (CDV), causes acute neurological signs of viral encephalitis such as seizures and myoclonus, lesions resemble childhood acute viral encephalitis and subacute sclerosing panencephalitis

124
Q

animal model for Torticollis

A

Callithrix jacchus

125
Q

characteristics of model for Torticollis

A

unilateral injection of 6-hydroxy-dopamine into the lateral hypothalamus resulted in persisting (days to weeks) severe torticollis with the head deviated toward the side of the lesion

126
Q

animal model of Adenosis and clear cell adenocarcinoma of the vagina and cervix

A

Cebus apella

127
Q

characteristics of model of Adenosis and clear cell adenocarcinoma of the vagina and cervix

A

in utero exposure to DES (diethylstilbestrol

128
Q

animal model of Chlamydial infections

A

NW, OW, and great apes

129
Q

characteristics of animal model of Chlamydial infections

A

Chlamydia trachomatis infection of primate genital tract, pathologic changes similar to humans. Owl monkey model for ocular trachoma

Trachoma is major blinding disease

130
Q

animal model for Twinning, Chimerism, and immunologic tolerance

A

Callithrix and Saguinus spp

131
Q

characteristics of twining model

A

blood chimerism is the norm in marmoset twins as functional vascular anastomosis between fetuses always occur. As in humnas, the freemartin condition does not occur

132
Q

animal model of labor and pelvic organ prolapse

A

Saimiri spp

133
Q

characteristics of labor and pelvic organ prolapse

A

fetal rotation occurs like in women,

134
Q

animal model for Legionnaires’ Disease

A

Callithrix jacchus

Macaca mulatta

Chlorocebus aethiops

(cavia porcellus most susceptible)

135
Q

production of Legionnaires’ model

A

production of small particle aerosol of L. pneumophila which mimics that inhaled by patients.

136
Q

characteristics of Legionnaires’ model

A

acute fibrinopurulent bronchopneumonia, organism survives and multiplies in lung macrophages

137
Q

animal model for Ankylosing Spondylitis

A

aged Squirrel monkeys

138
Q

characteristics of model for ankylosing spondylitis

A

signs usually in older animals, affected monkeys are reluctant to move, may refuse to rise and are likely to be attacked by cage mates. Spondylitis usually begins in sacroiliac joints.

139
Q

animal model for cartilage allografts

A

Callithrix jacchus

140
Q

characteristics of cartilage allografts

A

transplanted allografts of cultured mandibular condylar cartilage appeared to have the ability to promote cartilaginous repair and regeneration of orthopedic articular wounds

141
Q

animal model for Syndactyly

A

Saguinus nigricollis

142
Q

characteristics of Syndactyly model

A

abnormal soft tissue union of the digits, antosomal recessive trait

143
Q

animal model for repetitive strain injury

144
Q

characteristics of repetitive strain injury model

A

Aotus monkeys are trained to repetitively open and close a handpiece. Animals that used a rapid, stereotypical hand squeezing technique developed a task-specific movement dysfunction. Animals that used a variable shoulder-pulling strategy did not develop movement problems

145
Q

animal model for lead poisoining

A

Saimiri, Cebus

146
Q

characteristics of lead poisoining model

A

occurs in infants with pica, signs similar to those seen in man. Notable difference is the presence of demylination in some simian brains and spinal cords not reported to occur to a significant degree in man. clinical signs are weakness, paralysis, amaurosis (vision loss or weakness that occurs without an apparent lesion affecting the eye)

147
Q

animal model for Thalidomide syndrome

A

Callithrix jacchus

148
Q

animal model for vesicoureteral reflux

A

NHP, but Rhesus are ideal

149
Q

characteristics of vesicoureteral reflux model

A

NHPs show same low incidence of chronic phelonephritis and vesicoureteral reflux as pregnant women and infants

150
Q

animal model of hydronephrosis of pregnancy

151
Q

characteristics of hydronephrosis of pregnancy

A

incidence same in man and monkey, right ureter most often affected, caused by obstruction of ureter by gravid uterus.

152
Q

animal model of carcinoma of the urinary bladder

A

Cebus apella

153
Q

characteristics of carcinoma of the urinary bladder model

A

inflammatory response to schistosome eggs produce acute and chronic cystitis and uteritis, develop multifocal urethelial lesions that tend to regress as the infection become less active and changes are more hyperplastic rather than neoplastic

154
Q

animal model of Burkitts lymphoma

A

Saguinus oedipus, Aotus, Ateles geoffroyi

155
Q

characteristics of Burkitt’s lymphoma

A

herpesvirus saimiri and ateles isolated from apparently healthy squirrel and spider monkeys respectively. H. saimiri in tamarins, spider monkeys and owls produces malignant lymphoma with leukemia. H. ateles can induce in S. oedipus

156
Q

animal model for hemolytic anemia of premature infants

A

Cebus albifrons, apella

157
Q

characteristics of hemolytic anemia of premature infants

A

induced in young growing animals fed diets high in polyunsaturated fats, NW are more susceptible

158
Q

animal model for folate deficiency, megaloblastic anemia

A

Cebus albifrons

159
Q

characteristics of folate deficiency diet

A

three year old Cebus albirfons were fed a folate deficient diet and developed same stage of disease that humans did

160
Q

Cercocebus atys are a model for?

A

AIDS/SIV/ leprosy

161
Q

Chlorocebus spp are a model for?

A

Yellow fever, plague, leprosy, Hepatitis, Legionnaires’ Disease, varicella, atherosclerosis

162
Q

Erythrocebus patas are a model for?

A

pregnancy toxemia, Varicella infection

163
Q

Chimpanzees are a model for?

A

AIDS, Hepatitis A,B, C,E, vaccine development and final safety testing, congnition and language development

164
Q

animal models for HIV

A

Macaca arctoides, cyclopis, fascicularis, mulatta, nemestrina, Pan troglodytes, Papio spp

165
Q

characteristics of HIV infection in macaques

A

cannot be infected with HIV-1. Pig tailed macaques can be infected but fail to develop disease. HIV2 (more similar to SIV) can infect pig-tailed macaques and baboons

166
Q

characteristics of SIV infection

A

outside their normal host range, especially in macaques, these viruses cause an AIDS like disese similar to that of HIV infected patients

167
Q

natural hosts for SIV infection

A

African green monkeys, sooty mangaby

168
Q

animal model for cardiopulmonary disease/ pulmonary hypertension, cor pulmonale and endocardial fibroelastosis

A

Macacca arctoides

169
Q

characteristics of induced model of pulmonary hypertension

A

2% monocrotaline solution injected SQ in infant M. arctoides

170
Q

animal model for macular cyst

A

Macaca fascicularis

171
Q

induction of animal model for macular cyst

A

injec Perfluoropropane (C3F8) into the eye, develop in about 3 months after injection

172
Q

animal model for diabetes mellitus

A

Macaca nigra is classic

173
Q

ABO blood group antigens are present on which cell types

A

endothelial cells, exocrine secreations, primary sensory neurons,

NOT ERYTHROCYTES, use saliva for typing not blood

174
Q

animal model for varicella infection

A

Erythrocebus patas

Chlorocebus aethiops

175
Q

life cycle of malaria

A

sporozoite penetrates and goes to hepatocyte to become trophozoite matures to Schizont, differentiates into merozoite that invades RBS’s

176
Q

animal modesl for leprosy

A

Cercocebus torquatus atys

Pan troglodytes

Chlorocebus aethiops

Macaca mulatta

177
Q

animal model for Tuberculosis

A

Macaca fascicularis

178
Q

characteristics of animal model for TB

A

Macaca fascicularis is the first good model for chronic TB in humans, develop pulmonary disease in people with progression to clinical syndromes

179
Q

animal model for male pattern baldness

A

Macaca arctoides

180
Q

animal model for nonalcholic fattly liver disease

A

Macaca radiata

181
Q

animal model for meningoencephalocele

A

MAcaca mulatta

184
Q

animal model for saccular cerebral aneurysms

A

NHPs in general

185
Q

creation of induced animal model for saccular cerebral aneurysms

A

ligation of one common carotid artery, production of experimental hypertension and feeding of A-aminopropionitrile

186
Q

animal model for hydrocephalus

A

Macaca mulatta

187
Q

creation of induced animal model of congenital hydrocephalus

A

intracerebral inoculation with an attenuated influenza A vaccine cirus in fetal monkeys

188
Q

animal model for huntington’s disease

A

Macaca fascicularis

Papio sp

189
Q

creation of induced model of Huntington’s disease

A

chronic administration of 3NP

injections of quinolinic acid into the striatum

190
Q

animal model of toxemia of pregnancy

A

Erythrocebus patas

191
Q

characteristics of spontaneous model of Toxemia of Pregnancy

A

abrupt onset between day 7 prepartum and the day of parturition

does not progress beyond preeclamptic stage

192
Q

animal model for preeclampsia

A

Macaca mulatta

193
Q

induction of model for preeclampsia

A

chronic constriction of the lower aorta

194
Q

animal model for gonorrhea

A

Pan troglodytes

195
Q

characteristics of model of Gonorrhea

A

Chimpanzee is unique in its susceptibility to mucosal surface infection, can study pathogenesis, mechanisms of host response, treatments, and vaccines

196
Q

animal model for endometriosis

A

Macaca mulatta

197
Q

Animal model for resentosis

A

Cynomologys monkeys

198
Q

characteristics of model for restenosis

A

fed an atherogenic diet for 3 months

angioplasty performed

response to angioplasty appears to closely resemble that in humans

199
Q

animal model for scrub typhus

A

Macaca fascicularis

Presbytis cristatus

200
Q

characteristics of Scrub typhus model

A

Rickettsia tsutsugamushi

cynos develop same clinical response as humans

201
Q

animal model for lymp neuroborreliosis

A

Macaca mulatta

202
Q

characteristics of model for Lyme Neuroborreliosis

A

Lyme= Borelia burgdorferi,

macaques demonstrate many of the clinical and pathological features of the disease in humans including cutaneous rash, myocarditis, CSF pleocytosis, and CNS meningitis

203
Q

animal model for cytomegalovirus

A

Macaca mulatta

204
Q

characteristics of model of cytomegalovirus

A

infection of Rhesus with rhesus cytomegalovirus is model for human cytomegalovirus infection

lessons learned from RhCMV should have direct clinical relevance to HCMV and the design of protective vaccines

205
Q

animal model of alzheimer’s disease

A

aged Macaca mullata

206
Q

characteristics of model for alzheimer’s disease

A

have progressive cerebral deposition of the amyloid beta-protein

207
Q

animal model for Experimental Allergic Encephalomyelitis

A

Macaca mulatta

Macaca fascicularis

marmosets

208
Q

creation of animal model for Experimental Allergic Encephalomyelitis

A

intradermal injection of homologous myelin basic protein in CFA

causes a delayed type hypersensitivity reation to host myelin, leads to fatal demyelinating, necrotizing inflammation in the brain and spinal cord

ACLAM study sets (22 decks)

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