NW and OW NHP models Flashcards
1
Q
Callithrix spp are used for
A
Parkinson’s disease
Multiple sclerosis
hemochromatosis
infectious diseases (hepatitis, EBV, malaria)
2
Q
Saguinus spp used for
A
viral hepatitis
colonic adenocarcinoma
inflammatory bowel disease
viral oncology
3
Q
Saimiri spp used for
A
pharmacology/toxicology
infectious disease( malaria, CJD, spong encephala)
labor and pelvic organ prolapse
stress, aging
4
Q
Cebus spp used for
A
pharmacology/toxicology
viral oncogenesis
purine metabolism
atherosclerosis
nutrition
5
Q
Aotus spp used for
A
infectious diease (malaria, leishmaniasis, viral oncogeneic viruses, viral hepatitis A) glomerulonephritis
atherosclerosis
immunology
vision
6
Q
Lagothrix spp used for
A
(Woolly monkey)
hypertension
cardiovascular research
hepatitis B virus
7
Q
animal model for dental carries
A
all NHP
8
Q
creation of induced model for dental carries
A
experimentally induced with Strep mutans combined with daily meals rich in sugar
9
Q
animal model for chronic destructive periodontitis
A
Callithrix jacchus
10
Q
creation of induced model for chronic destructive periodontitis
A
induce experimentally by placement of peri-dental silk ligatures or orthodontic elastics as well as surgical removal of alveolar bone
11
Q
animal model for Bacillary Dysentery/Shigellosis
A
most NHP, gorillas seem to be very susceptible
12
Q
species of Shigellosis responsible for dysetery
A
S. flexneri, boydii, sonnei
13
Q
clinical signs of Bacillary Dysentery
A
edematous face, liquid stools with mucus and blood. Clinical features and gross microscopic lesions of the colon of the monkey infected with shigellae are indistinguishable from human shigellosis. colonic changes are similar to those in man
14
Q
animal model for Helicobacter gastritis
A
Old and New World Primates
15
Q
purpose of model for Colibacillosis
A
evaluation of a prototype enterotoxigenic E. coli subunit vaccine
16
Q
animal model for Enteropathogenic Colibacillosis
A
Pan tryglodytes, Pongo pygmaeus
17
Q
characteristics of Enteropathogenic Colibacillosis
A
clinical and pathological features are similar to those in human infants. Same E. coli serotypes are found. studied in anthropoid apes, under 2 years of age.
18
Q
animal model for Campylobacteriosis
A
Aotus nancymae, clinical course similar to that observed in humans
19
Q
animal model for Cryptosporidosis
A
Macaca nemestrina
20
Q
creation of induced Cryptosporidiosis model
A
inoculation of oocysts via nasogastric tube results in clinical enteritis and fecal passage of large numbers of cryptosporidial oocysts. partial acquired immunity has been demonstrated
21
Q
animal model for Helicobacter gastritis
A
old and new world NHPs
22
Q
characteristics of Helicobacter gastritis model
A
NHPs commonly have subclinical infections but with histologic evidence of chronic gastritis and are often co-infected with H. pylori. Rhesus have been used to induce H. pylori gastritis and for therapeutic vaccine trials
23
Q
animal model for colonic adenocarcinoma
A
Saguinus oedipus
24
Q
characteristics of model for colonic adenocarcinoma
A
spontaneously occurring primary adenocarcinoma of cecum, colon, and rectum, related to marmoset wasting disease
25
animal model for ulcerative colitis
Saguinus oedipus
26
model for ulcerative colitis
spontaneous, associated with decreased fecal short-chain fatty acid levels, progressive inflammation in a pattern similar to human colitis
27
purpose of model for ulcerative colitis
assess new treatments of inflammatory bowel disease
28
animal model of colitis cystica profunda
Saguinus mystax and S. labiatus, spontaneous
29
human disease of cystica profunda
characterized by mucus-filled cysts in the colonic and cecal mucosa, submucosa and muscularis propria, frequently lined by demonstrable epithelium, etiology unknown
30
animal model for Chron's disease
Saguinus mystax and S. labiatus
31
chracteristics of model for Chron's disease
spontaneous terminal ileitis resembling Chron's disease in humans has been reported. etiology unknown, primary lesion is ulceration and thickening of the terminal portion of the ileum
32
animal model for Atherosclerosis
Cebus spp, Saimiri sciureus, addition of cholesterol to the diet results in hypercholesterolemia and exacerbation of atherosclerosis
Macaca mulatta, fascicularis, Chlorocebus aethiops, Papio spp
33
characteristics of spontaneous model for atherosclerosis
can study plaque regression and atherogenesis studies, and also effects of multiple risk factors suck as diet, stress, hormones, pharmacologic agents, and psychosocial factors
34
animal model for hypertension
Aotus nancymae, Lagothrix lagotricha
35
characteristics of model for hypertension
spontaneous, neural based, hyperactive responses of the sympathetic nervous system
36
animal model for infantile strabisus
Saimiri spp
Macaca nemestrina, fascicularis,
Papio cynocephalus
37
characteristics of model for strabismus
esotropia in newborm monkeys by surgical tenotomy of both lateral rectus muscles
or injection of Botulinum A neurotoxin (reversible, can study recovery)
38
animal model for retinal ganglion cell morphology
Callithrix jacchus
39
characteristics of model for retinal ganglion cell morphology
good visual acuity and its retinal and subcortical pathways are very similar to humans
40
animal model for retinal degeneration
Saimiri spp
41
characteristics of model of retinal degeneration
spontaneous retinal degeneration similar to human degenerative disorder
42
animal model for retinal detachment
Aotus spp
43
characteristics of model for retinal detachment
correlations of naturally occurring detachments with long-term retinal detachment in owl monkeys
44
animal model for myopia
Callithrix jaccus
Macaca mulatta, arctoides (cats, tree shrews, marmosets, guinea pigs, and chickens)
45
characteristics of model for myopia
induced in infant animals, eyelids are surgically fused at birth and kept closed for one year
46
animal model for motion sickness
Saimiri spp
47
characteristics of model for motion sickness
induces by vertical oscillation and horizontal rotation, squirrel monkeys will vomit and are more active during test than most other NHPs
48
uses of model of motion sickenss
testing anit-motion sickness preparations
49
animal model of lymphocytic thyroiditis
Callithrix jacchus
50
characteristic of model of lymphocytic thyroiditis
chronic lymphyocytic auto-immune thyroiditis in conjunction with circulating antibodies to thyroid antigen, marmoset lesions are comparable to humans, marmosets show same sex predilection as seen in humans
51
animal model for stress
Saimiri, Callithrix
52
characteristics of model for stress
total circulating cortisol is 10 times greater than in humans, thought to be due to the disruptive presence of immature offspring that produces a chronic cortisol increase in captive adult squirrel monkeys
53
animal model for erythroblastosis fetalis
marmosets Callithrix spp
54
animal model for IgE studies
Callithrix jacchus
55
characteristics of erythroblastosis fetalis
similar fetoplacental situation, knowledge of blood groups
56
animal model for toxoplasmosis
Lagothrix lagothricha, Aotus lemurinus
57
characteristics of toxoplasmosis in NHP model
acute spontaneous, more frequent in NW than OW, a single case report in a male woolly monkey, source eating raw meat
58
animal model of malaria
Aotus spp, Saimri spp
Chipmanzee, Macaca mulatta
59
species of Malaria causing disease in man
Plasmodia falciparum, malariae, vivax, ovale
60
characteristics of malaria model
Aotus are susceptible to P. vivax, malaria is host specific, , S boliviensis are susceptible to infection with P. falciparum and different strains of P. vivax
Chimpanzees are the only known host for P. ovale
M.mulatta can be infected with a virulent strain of P. knowlesi
61
what species does the world health organization recommend as a model for evaluation of malaria vaccine candidates
Aotus nancymae
62
animal model for Haemobartonellosis
Saimri spp
63
characteristics of model for Haemobartonellosis
patent infection occurs following splenectomy, carriers commin in colony reared squirrel monkeys. reason for treating splenectomized squirrel monkeys with oxytetracycine before use in malaria studies.
64
animal model for Chaga's Disease
Cebus paella, chronic chagasic cardiomyopathy
65
characteristics for model of Chaga's Disease
cardiac lesions, focal or multifocal mononuclear infiltrates and/or isolated fibrosis
66
animal model for Cutaneous and Visceral Leishmaniasis
Aotus spp, Saguinus geoffroyi
visceral leshmaniasis- Chlorocebus aethiops
(hamsters are original animal model)
67
characteristics of model for Leishmaniasis
NHP develop self-limiting skin lesions with L. braxiliensis complex and severe to fatal visceral disease with L. donovani. transmitted by sandflies
68
animal model for Lymphocytic Choriomeningitis Virus Infection
Cebus albifrons
also: Macaca mulatta and fascicularis
69
characteristics of LCMV model
most common syndrome is meningitis nearly all LCM patients recover
70
animal model for yellow fever
Marmosets, tamarins, owl, spider, and squirrel monkeys, rhesus
71
characteristics of model of yellow fever
pathological species seen in NHP is similar to those in man
M. mulatta= disease resembles hyperacute form seen in man
NW are all extremely susceptible, except Cebus which are usually asymptomatic and Ateles are resistant
72
animal model for Dengue fever
Aotus nancymae
73
characteristics of Dengue fever model
Aotus develops viremia but no Dengue fever, or Dengue shock syndrome like humans
74
animal model of Eastern Equine Encephalitis
Aotus nancymae
75
characteristics of EEE model
A. nancymae sustains short term viremia and produces IgM and IgG post EEEV infection but no clinical disease, non-lethal model for evaluation of candidate vaccines against EEEV
76
animal model of Argentinian Hemorrhagic Fever
Callithrix jacchus
77
characteristics of Argentinian Hemorrhagic Fever
experimentally induced disease is quite similar to the natural infection of man
78
animal model of measles
Saimiri sciureus, Saguinus mystax
Masaca fascicularis
79
characteristics of model of measles
severe disease when introduced to captive NW monkey, typically see GI effects such as necrotizing colitis
80
animal model for human T-cell Lymphotropic virus (non-hodgkin's lymphoma)
squirrel monkeys
Papio sp
81
characteristics of HTLV
chronically infected monkeys developed high titers of antibodies against structural proteins of the virus, as do HTLV humans, squirrel monkeys may be useful to study the pathogenesis of HTLV and for evaluating new candidate vaccines
HTLV is similar to STLV-1
82
animal model for Epstein-Barr Virus
Callithrix jacchus
Macaca mulatta
83
characteristics of EBV model
the B95-9 strain of EBV induces malignant lymphomas in cotton top tamarins, used to evaluate EBV vaccines
in Macaques develop key aspects of human infection
84
animal model fro Klebsiella pneumonia
SQuirrel monkey, marmosets
85
characteristics for Klebsiella
lobar pneumonia develops after administration of only 700 organisms
86
animal model for Helicobacter pylori infection
Saimiri spp
87
characteristics of Helicobacter infection model
experimentally induced infection in Saimiri, used in immunogenicity and safety studies
88
which hepatitis viruses are enterically transmitted?
A and E
89
which hepatitis viruses are parenterally transmitted?
B,C, delta
90
which hepatitis viruses produce disease in both OW and NW primates
A and E
91
which viruses induce hepatitis in only a few OW species
B,C, delta
92
which NHP species are susceptible to both Hep A and B
marmosets and chimpanzees
93
which NHP species are most susceptible to Hep E
cynos and Aotus monkeys
94
what is the animal model for Hep A
Aotus spp, Marmosets and Tamarins
95
model of choice for Hep A research
Marmosets
96
model of choice for Hep B research
Chimpanzee
97
model of choice for Hep E research
Aotus monkey
98
closest viral relative to Hep C that can be used as a model?
GBV-B, causes acute hepatitis, increased liver enzymes that quickly return to normal as virus is cleared
99
animal model for GBV-B as model for Hep C research
Saguinus spp, Callithrix jaccus
100
animal model for Cholelithiasis
Aotus spp, Callithrix jacchus, Saimiri spp
101
characteristics of Cholelithiasis
Aotus and Callithrix, not based on cholesterol in the diet, Squirrel monkey requires addition of cholesterol to the diet. The frequency of stone formation appears to be inversely related to the concentration of cholesterol in the plasma. There is a suggestion that regimens which lower plasma cholesterol may result in accelerated gallstone formation.
102
animal model of cholesterol cholelithiasis
Aotus spp
103
characteristics of cholesterol cholelithiasis
Aotus monkeys spontaneously develop cholesterol gallstones when fed a diet supplemented with 1.5% cholesterol.
104
NHP animal model for Gilbert's syndrome
Saimiri boliviensis
105
characteristics of model for Gilbert's syndrome
nonhemolytic unconjugated hyperbilirubinemia, defect in hepatic uptake of unconjugated bilirubin and/or a conjugating enzyme deficiency, plasma of normal Bolivian squirrel monkeys what are fasted for 24hrs have a hyperbilirubinemia. most likely due to the presence of the hepatic enzyme UDP-glucuronyl transferase that results in a higher plasma and hepatic bilirubin level during a fast.
106
animal model of hemochromatosis
Callithrix jacchus
107
characteristics of model of hemochromatosis
characterized by excessive absorption of ingested iron, saturation of iron-binding protein, and deposition of hemosiderin in tissues especially liver, pancreas, and skin. will seek Kupffer cells in the liver lining sinusoids eating all the hemosiderin
108
animal model of gout
Cebus, Ateles, Lagothrix, Saguinus spp
109
characteristics of model of gout
NHP and humans lack uricase leading to hyperuricemia with subsequent deposition of urates in and about the joints.
110
animal model of Parkinson's Disease
Callithrix jacchus
Macaca mulatta
Macaca nemestrina
Chlorocebus aethiops
111
characteristics of Parkinson's model
acute exposure to MPTP causes motor symptoms/signs indistinguishable from PD. Lewy bodys are the characteristic intracellular inclusion seen in the brain. MPTP induces and acute, toxic disorder associated with injury to nigral neurons, whereas PD is a chronically progressive disorder of unknown cause. Experimental animals do not develop the cognitive and memory impairments that occur in PD
112
animal model for Cerebral Beta-Amyloid Angiopathy
Saimiri spp
113
characteristics of Cerebral Beta-Amyloid Angiopathy
manifest beta-amyloid deposition in the cerebral blood vessels with age. used to test in vivo beta-amyloid labeling strategies
114
animal model for Multiple Sclerosis/ Experimental Allergic Encephalomyelitis
Callithrix jacchus
Macaca mulatta
Macaca fascicularis
115
characteristics of Multiple Sclerosis model
called experimental allergic or autoimmune encephalomyelitis. sensitization to myelin basic protein (BP) induces a cell-mediated delyated-type hypersensitivity reaction to host myelin
116
how do you causes relapsing remitting EAE
treat acute attack with dexamethasone for 3 days
117
animal model for Spongiform Encephalopathy
Saimiri spp, Saguinus spp
118
characteristics of Spongiform encephalopathy model
mental and physical abilities deterioriate and a myrial of tiny holes appear in the cortex, causing it to appear like a sponge.
119
animal model of neurodegenerative disease
aged Saimiri spp
120
characteristics of neurodegenerative disease model
aged NHP develop age associated behavioral and brain abnormalities similar to those in aged humans such as degenerative changes, neuritis and deposits of amyloid in senile plaques and around blood vessels
121
animal model for Lissencephaly
Saimiri spp
122
characteristics of Lissencephaly model
Saimiri is highest species of primate with a lissencephalic brain, used to study cortical spreading depression in a highly encephalized brain
123
animal model for Viral Encephalitis and epilepsy
intracerebral injection with canine distemper virus (CDV), causes acute neurological signs of viral encephalitis such as seizures and myoclonus, lesions resemble childhood acute viral encephalitis and subacute sclerosing panencephalitis
124
animal model for Torticollis
Callithrix jacchus
125
characteristics of model for Torticollis
unilateral injection of 6-hydroxy-dopamine into the lateral hypothalamus resulted in persisting (days to weeks) severe torticollis with the head deviated toward the side of the lesion
126
animal model of Adenosis and clear cell adenocarcinoma of the vagina and cervix
Cebus apella
127
characteristics of model of Adenosis and clear cell adenocarcinoma of the vagina and cervix
in utero exposure to DES (diethylstilbestrol
128
animal model of Chlamydial infections
NW, OW, and great apes
129
characteristics of animal model of Chlamydial infections
Chlamydia trachomatis infection of primate genital tract, pathologic changes similar to humans. Owl monkey model for ocular trachoma
Trachoma is major blinding disease
130
animal model for Twinning, Chimerism, and immunologic tolerance
Callithrix and Saguinus spp
131
characteristics of twining model
blood chimerism is the norm in marmoset twins as functional vascular anastomosis between fetuses always occur. As in humnas, the freemartin condition does not occur
132
animal model of labor and pelvic organ prolapse
Saimiri spp
133
characteristics of labor and pelvic organ prolapse
fetal rotation occurs like in women,
134
animal model for Legionnaires' Disease
Callithrix jacchus
Macaca mulatta
***_Chlorocebus aethiops_***
(cavia porcellus most susceptible)
135
production of Legionnaires' model
production of small particle aerosol of L. pneumophila which mimics that inhaled by patients.
136
characteristics of Legionnaires' model
acute fibrinopurulent bronchopneumonia, organism survives and multiplies in lung macrophages
137
animal model for Ankylosing Spondylitis
aged Squirrel monkeys
138
characteristics of model for ankylosing spondylitis
signs usually in older animals, affected monkeys are reluctant to move, may refuse to rise and are likely to be attacked by cage mates. Spondylitis usually begins in sacroiliac joints.
139
animal model for cartilage allografts
Callithrix jacchus
140
characteristics of cartilage allografts
transplanted allografts of cultured mandibular condylar cartilage appeared to have the ability to promote cartilaginous repair and regeneration of orthopedic articular wounds
141
animal model for Syndactyly
Saguinus nigricollis
142
characteristics of Syndactyly model
abnormal soft tissue union of the digits, antosomal recessive trait
143
animal model for repetitive strain injury
Aotus spp
144
characteristics of repetitive strain injury model
Aotus monkeys are trained to repetitively open and close a handpiece. Animals that used a rapid, stereotypical hand squeezing technique developed a task-specific movement dysfunction. Animals that used a variable shoulder-pulling strategy did not develop movement problems
145
animal model for lead poisoining
Saimiri, Cebus
146
characteristics of lead poisoining model
occurs in infants with pica, signs similar to those seen in man. Notable difference is the presence of demylination in some simian brains and spinal cords not reported to occur to a significant degree in man. clinical signs are weakness, paralysis, amaurosis (vision loss or weakness that occurs without an apparent lesion affecting the eye)
147
animal model for Thalidomide syndrome
Callithrix jacchus
148
animal model for vesicoureteral reflux
NHP, but Rhesus are ideal
149
characteristics of vesicoureteral reflux model
NHPs show same low incidence of chronic phelonephritis and vesicoureteral reflux as pregnant women and infants
150
animal model of hydronephrosis of pregnancy
any NHP
151
characteristics of hydronephrosis of pregnancy
incidence same in man and monkey, right ureter most often affected, caused by obstruction of ureter by gravid uterus.
152
animal model of carcinoma of the urinary bladder
Cebus apella
153
characteristics of carcinoma of the urinary bladder model
inflammatory response to schistosome eggs produce acute and chronic cystitis and uteritis, develop multifocal urethelial lesions that tend to regress as the infection become less active and changes are more hyperplastic rather than neoplastic
154
animal model of Burkitts lymphoma
Saguinus oedipus, Aotus, Ateles geoffroyi
155
characteristics of Burkitt's lymphoma
herpesvirus saimiri and ateles isolated from apparently healthy squirrel and spider monkeys respectively. H. saimiri in tamarins, spider monkeys and owls produces malignant lymphoma with leukemia. H. ateles can induce in S. oedipus
156
animal model for hemolytic anemia of premature infants
Cebus albifrons, apella
157
characteristics of hemolytic anemia of premature infants
induced in young growing animals fed diets high in polyunsaturated fats, NW are more susceptible
158
animal model for folate deficiency, megaloblastic anemia
Cebus albifrons
159
characteristics of folate deficiency diet
three year old Cebus albirfons were fed a folate deficient diet and developed same stage of disease that humans did
160
Cercocebus atys are a model for?
AIDS/SIV/ leprosy
161
Chlorocebus spp are a model for?
Yellow fever, plague, leprosy, Hepatitis, Legionnaires' Disease, varicella, atherosclerosis
162
Erythrocebus patas are a model for?
pregnancy toxemia, Varicella infection
163
Chimpanzees are a model for?
AIDS, Hepatitis A,B, C,E, vaccine development and final safety testing, congnition and language development
164
animal models for HIV
Macaca arctoides, cyclopis, fascicularis, mulatta, nemestrina, Pan troglodytes, Papio spp
165
characteristics of HIV infection in macaques
cannot be infected with HIV-1. Pig tailed macaques can be infected but fail to develop disease. HIV2 (more similar to SIV) can infect pig-tailed macaques and baboons
166
characteristics of SIV infection
outside their normal host range, especially in macaques, these viruses cause an AIDS like disese similar to that of HIV infected patients
167
natural hosts for SIV infection
African green monkeys, sooty mangaby
168
animal model for cardiopulmonary disease/ pulmonary hypertension, cor pulmonale and endocardial fibroelastosis
Macacca arctoides
169
characteristics of induced model of pulmonary hypertension
2% monocrotaline solution injected SQ in infant M. arctoides
170
animal model for macular cyst
Macaca fascicularis
171
induction of animal model for macular cyst
injec Perfluoropropane (C3F8) into the eye, develop in about 3 months after injection
172
animal model for diabetes mellitus
Macaca nigra is classic
173
ABO blood group antigens are present on which cell types
endothelial cells, exocrine secreations, primary sensory neurons,
NOT ERYTHROCYTES, use saliva for typing not blood
174
animal model for varicella infection
Erythrocebus patas
Chlorocebus aethiops
175
life cycle of malaria
**sporozoite** penetrates and goes to hepatocyte to become **trophozoite** matures to **Schizont**, differentiates into **merozoite** that invades RBS's
176
animal modesl for leprosy
Cercocebus torquatus atys
Pan troglodytes
Chlorocebus aethiops
Macaca mulatta
177
animal model for Tuberculosis
Macaca fascicularis
178
characteristics of animal model for TB
Macaca fascicularis is the first good model for chronic TB in humans, develop pulmonary disease in people with progression to clinical syndromes
179
animal model for male pattern baldness
Macaca arctoides
180
animal model for nonalcholic fattly liver disease
Macaca radiata
181
animal model for meningoencephalocele
MAcaca mulatta
182
183
184
animal model for saccular cerebral aneurysms
NHPs in general
185
creation of induced animal model for saccular cerebral aneurysms
ligation of one common carotid artery, production of experimental hypertension and feeding of A-aminopropionitrile
186
animal model for hydrocephalus
Macaca mulatta
187
creation of induced animal model of congenital hydrocephalus
intracerebral inoculation with an attenuated influenza A vaccine cirus in fetal monkeys
188
animal model for huntington's disease
Macaca fascicularis
Papio sp
189
creation of induced model of Huntington's disease
chronic administration of 3NP
injections of quinolinic acid into the striatum
190
animal model of toxemia of pregnancy
Erythrocebus patas
191
characteristics of spontaneous model of Toxemia of Pregnancy
abrupt onset between day 7 prepartum and the day of parturition
does not progress beyond preeclamptic stage
192
animal model for preeclampsia
Macaca mulatta
193
induction of model for preeclampsia
chronic constriction of the lower aorta
194
animal model for gonorrhea
Pan troglodytes
195
characteristics of model of Gonorrhea
Chimpanzee is unique in its susceptibility to mucosal surface infection, can study pathogenesis, mechanisms of host response, treatments, and vaccines
196
animal model for endometriosis
Macaca mulatta
197
Animal model for resentosis
Cynomologys monkeys
198
characteristics of model for restenosis
fed an atherogenic diet for 3 months
angioplasty performed
response to angioplasty appears to closely resemble that in humans
199
animal model for scrub typhus
Macaca fascicularis
Presbytis cristatus
200
characteristics of Scrub typhus model
Rickettsia tsutsugamushi
cynos develop same clinical response as humans
201
animal model for lymp neuroborreliosis
Macaca mulatta
202
characteristics of model for Lyme Neuroborreliosis
Lyme= Borelia burgdorferi,
macaques demonstrate many of the clinical and pathological features of the disease in humans including cutaneous rash, myocarditis, CSF pleocytosis, and CNS meningitis
203
animal model for cytomegalovirus
Macaca mulatta
204
characteristics of model of cytomegalovirus
infection of Rhesus with rhesus cytomegalovirus is model for human cytomegalovirus infection
lessons learned from RhCMV should have direct clinical relevance to HCMV and the design of protective vaccines
205
animal model of alzheimer's disease
aged Macaca mullata
206
characteristics of model for alzheimer's disease
have progressive cerebral deposition of the amyloid beta-protein
207
animal model for Experimental Allergic Encephalomyelitis
Macaca mulatta
Macaca fascicularis
marmosets
208
creation of animal model for Experimental Allergic Encephalomyelitis
intradermal injection of homologous myelin basic protein in CFA
causes a delayed type hypersensitivity reation to host myelin, leads to fatal demyelinating, necrotizing inflammation in the brain and spinal cord
209
