other mouse models

Question 1

list the mouse models for retinal degeneration

Answer 1

C3H
FVB
SJL
CBA
outbred swiss

Question 2

what is the mutation that is responsible for retinal degeneration?

Answer 2

rd1 mutation of the Pde6b gene

Question 3

what is the defect seen in the obese mouse

Answer 3

Lep ob- leptin deficient

Question 4

what is the defect seen in the diabetes mouse

Answer 4

Lepr db- leptin receptor deficient

Question 5

on what chromosome is the gene coding for the leptin hormone?

Answer 5

Chr 6

Question 6

on what chromosome is the gene coding for the leptin receptor?

Answer 6

Chr 4

Question 7

what factors play a role in the development of the NOD diabetic model?

Answer 7

insulitis, T cell autoimmunity against islet cells. similar to type 1 diabetes,

Question 8

which mouse is a model for hodgkin’s lymphoma

Answer 8

SJL mice

Question 9

what is the process for creating a mouse model of allergic athsma

Answer 9

exposure to ovalbumin, IL4 knockout mice are sometimes used

Question 10

which strains are susceptible to audiogenic seigures

Answer 10

DBA
SJL
some FVB

Question 11

what is the mouse model for pituitary adenoma>

Answer 11

FVB

Question 12

what is the mouse model for teratoma

Answer 12

129

Question 13

characteristics of Apolipoprotein E deficient mouse

Answer 13

increased total cholesterol
spontaneously develop aterial lesions
atheroscelrosis progression similar to humans
lesions develop more quickly if fed a Western diet

Question 14

characteristics of LDL receptor KO mouse

Answer 14

high cholesteral levels on regular and even higher on high fat diet
-atherosclerosis, fatty liver disease

Question 15

characteristics of lethal yellow mouse?

Answer 15

homozygotes die as embryos
obesity, insulin resistance, hypergylcemia
elevated malic enzyme in liver

Question 16

AKR as susceptible to what cancer

Answer 16

leukemia, associated with retrovirus

thymic lymphoma

Question 17

SJL are susceptible to what cancers

Answer 17

reticulum cell sarcomas (hodgkins lymphoma)

Question 18

induction of EAE in SJL mice

Answer 18

immunization with proteolipid protein (PLP), myelin basic protein (MBP), or peptides corresponding to immunodominant epitopes MBP

Question 19

A/J and A/He mice are susceptible to what cancers

Answer 19

lung tumors

mammary adenocarcinomas

Question 20

piebald lethal mutation is on what locus

Answer 20

Ednrb(s-l)

Question 21

characteristics of piebald lethal mutation

Answer 21

disrupts development of melanocytes derived from neural crest
model for Hirschsprung’s disease, Waardenburg syndrome