mouse coat color Flashcards
pheomelanin is responsible for what color granules?
yellow/red
eumelanin is responsible for what color granules?
black/prown
Myo5a is responsible for what part of color production?
transport of melanin to keratinocytes
Tyrosinase is responsible for what part of color production?
converstion of tyrosine to melanin which leads to pigment formation
what gene encodes for Tyrosinase
Tyr
which genes control migration of melanocytes
Kitl, Kit, Ednrb
what disease is associated with piebald coat color?
megacolon
what disease is associated with dominant white?
congenital anemia, pups die within a few days after birth
what disease is associated with brindle color?
males die within 10-14 days, those that live and are homozygous females have slight tremors and uncoordinated gait
what disease is associated with homozygous dominant yellow coat color?
die on sixth day of gestation
what disease is associated with albino coat color?
blindness
what are the 5 genes responsible for the most common coat color vatiations in mice?
nonagouti brown albino dilution pink-eyed dilution
what chromosome is the nonagouti locus found on
Chr 2
what chromosome is the brown locus found on?
Chr 4
what chromosome is the albino locus found on?
Chr 7
What chromosome is the dilution locus found on?
Chr 9
What chromosome is the pink-eyed dilution found on?
Chr 7
which is the most polymorphic of the coat color loci?
the nonagouti
what is the new name for the B or b (black vs brown) locus
Tyrp
what is the new name for the C or c (pigmented vs albino) locus
Tyr
what is the new name for the D or d locus (non-dilute vs dilute)
Myo5a
what is the other name for the pink-eyed dilution locus
Oca (for oculocutaneous albinism) eumelanin content of the melanin granules in mice that are homozygous for the Oca locus is greatly diminished resulting in pink eyes and dilute coat color
what chromosome is the Kit locus located?
Chr 5
what phenotype is a mutation at the Kit locus responsible for?
black eyed white (white spotting loci)
the piebald mutation is caused by a mutation in the ____________ locus on Chr _________.
Ednrb, Chr 14
mutation at which locus results in the beige coat color. What chromosme is it located on?
Lyst, 13
what is the genotype of the coat color for a BALB/c
AbcD (A Tyrp1+ Tyr c, Myo5a+) aka albino
what is the genotype of the coat color for a C3H?
ABCD (A Tyrp1+ Tyr+ Myo5a+) aka black agouti
what is the genotype of the coat color for a C57BL/6?
aBCD (a Tyrp1+ Tyr+ Myo5a+) aka black non-agouti
what is the genotypoe of the coat color for a DBA
abCd (a Tyrp1b Tyr+ Myo5a d) aka dilute brown non-agouti
