mouse coat color

Question 1

pheomelanin is responsible for what color granules?

Answer 1

yellow/red

Question 2

eumelanin is responsible for what color granules?

Answer 2

black/prown

Question 3

Myo5a is responsible for what part of color production?

Answer 3

transport of melanin to keratinocytes

Question 4

Tyrosinase is responsible for what part of color production?

Answer 4

converstion of tyrosine to melanin which leads to pigment formation

Question 5

what gene encodes for Tyrosinase

Answer 5

Tyr

Question 6

which genes control migration of melanocytes

Answer 6

Kitl, Kit, Ednrb

Question 7

what disease is associated with piebald coat color?

Answer 7

megacolon

Question 8

what disease is associated with dominant white?

Answer 8

congenital anemia, pups die within a few days after birth

Question 9

what disease is associated with brindle color?

Answer 9

males die within 10-14 days, those that live and are homozygous females have slight tremors and uncoordinated gait

Question 10

what disease is associated with homozygous dominant yellow coat color?

Answer 10

die on sixth day of gestation

Question 11

what disease is associated with albino coat color?

Answer 11

blindness

Question 12

what are the 5 genes responsible for the most common coat color vatiations in mice?

Answer 12

nonagouti
brown
albino
dilution
pink-eyed dilution

Question 13

what chromosome is the nonagouti locus found on

Answer 13

Chr 2

Question 14

what chromosome is the brown locus found on?

Answer 14

Chr 4

Question 15

what chromosome is the albino locus found on?

Answer 15

Chr 7

Question 16

What chromosome is the dilution locus found on?

Answer 16

Chr 9

Question 17

What chromosome is the pink-eyed dilution found on?

Answer 17

Chr 7

Question 18

which is the most polymorphic of the coat color loci?

Answer 18

the nonagouti

Question 19

what is the new name for the B or b (black vs brown) locus

Answer 19

Tyrp

Question 20

what is the new name for the C or c (pigmented vs albino) locus

Answer 20

Tyr

Question 21

what is the new name for the D or d locus (non-dilute vs dilute)

Answer 21

Myo5a

Question 22

what is the other name for the pink-eyed dilution locus

Answer 22

Oca (for oculocutaneous albinism) eumelanin content of the melanin granules in mice that are homozygous for the Oca locus is greatly diminished resulting in pink eyes and dilute coat color

Question 23

what chromosome is the Kit locus located?

Answer 23

Chr 5

Question 24

what phenotype is a mutation at the Kit locus responsible for?

Answer 24

black eyed white (white spotting loci)

Question 25

the piebald mutation is caused by a mutation in the ____________ locus on Chr _________.

Answer 25

Ednrb, Chr 14

Question 26

mutation at which locus results in the beige coat color. What chromosme is it located on?

Answer 26

Lyst, 13

Question 27

what is the genotype of the coat color for a BALB/c

Answer 27

AbcD (A Tyrp1+ Tyr c, Myo5a+) aka albino

Question 28

what is the genotype of the coat color for a C3H?

Answer 28

ABCD (A Tyrp1+ Tyr+ Myo5a+) aka black agouti

Question 29

what is the genotype of the coat color for a C57BL/6?

Answer 29

aBCD (a Tyrp1+ Tyr+ Myo5a+) aka black non-agouti

Question 30

what is the genotypoe of the coat color for a DBA

Answer 30

abCd (a Tyrp1b Tyr+ Myo5a d) aka dilute brown non-agouti