primary sclerosing cholangitis Flashcards
1
Q
what is it
A
chronic liver disease characterised by fibrosis inflammatory destruction of both intra and extra hepatic bile ducts
2
Q
associated with
A
IBD - mainly ulcerative colitis
3
Q
genetics associated
A
HLA-A1-B8-DR3
4
Q
more common in men or women
A
men
5
Q
when is secondary PSC seen
A
patients with HIV
6
Q
symptoms
A
- usually always asymptomatic
but
- fluctuating pruritus
- jaundice
- cholangitis
7
Q
diagnosis
A
MRCP
8
Q
pathology
A
- inflammation of the intrahepatic biliary radicles
- scar tissue looks like onion tissue
9
Q
what is only proven treatment
A
liver transplantation
